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Bone mineral density and osteoporosis in heart transplanted patients : A single-center retrospective study at Skåne University Hospital in Lund 1988-2016

Löfdahl, Eveline LU ; Söderlund, Carl LU and Rådegran, Göran LU (2019) In Clinical Transplantation 33(3).
Abstract

Bone mineral density (BMD) in the lumbar spine and femoral neck, the incidence of osteoporosis, and survival up to 10 years after heart transplantation (HT) were investigated in 169 patients who underwent HT at Skåne University Hospital in Lund, Sweden, 1988-2016. Within the first year post-transplantation, mean (SD) BMD decreased by 3.9% (10.1) (P < 0.001) and 9.0% (10.5) (P < 0.001) in the lumbar spine and femoral neck, respectively. The cumulative incidence of osteoporosis in the lumbar spine and femoral neck increased rapidly within the first year after HT and was detected in 17% and 13% of the patients, respectively. A higher T score before HT was a negative predictor of osteoporosis up to 10 years post-HT in the lumbar spine... (More)

Bone mineral density (BMD) in the lumbar spine and femoral neck, the incidence of osteoporosis, and survival up to 10 years after heart transplantation (HT) were investigated in 169 patients who underwent HT at Skåne University Hospital in Lund, Sweden, 1988-2016. Within the first year post-transplantation, mean (SD) BMD decreased by 3.9% (10.1) (P < 0.001) and 9.0% (10.5) (P < 0.001) in the lumbar spine and femoral neck, respectively. The cumulative incidence of osteoporosis in the lumbar spine and femoral neck increased rapidly within the first year after HT and was detected in 17% and 13% of the patients, respectively. A higher T score before HT was a negative predictor of osteoporosis up to 10 years post-HT in the lumbar spine (HR 0.13; 95% CI 0.063-0.26; P < 0.001) and femoral neck (HR 0.54; 95% CI 0.34-0.85; P < 0.001). Moreover, only 13%, 14%, and 6% of the HT patients received calcium, vitamin D, and/or bisphosphonates before HT. In conclusion, BMD drops significantly during the first postoperative year. Optimization of BMD early among HT candidates, potentially through usage of osteoporosis preventive treatment, may be a future means to prevent osteoporosis late postoperatively.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone mineral density, heart transplantation, osteoporosis, T score
in
Clinical Transplantation
volume
33
issue
3
publisher
Wiley-Blackwell
external identifiers
  • scopus:85061004713
ISSN
0902-0063
DOI
10.1111/ctr.13477
language
English
LU publication?
yes
id
c462d962-c9f2-4b98-a4e2-48c17b9db0c1
date added to LUP
2019-02-12 11:49:20
date last changed
2019-06-28 07:48:07
@article{c462d962-c9f2-4b98-a4e2-48c17b9db0c1,
  abstract     = {<p>Bone mineral density (BMD) in the lumbar spine and femoral neck, the incidence of osteoporosis, and survival up to 10 years after heart transplantation (HT) were investigated in 169 patients who underwent HT at Skåne University Hospital in Lund, Sweden, 1988-2016. Within the first year post-transplantation, mean (SD) BMD decreased by 3.9% (10.1) (P &lt; 0.001) and 9.0% (10.5) (P &lt; 0.001) in the lumbar spine and femoral neck, respectively. The cumulative incidence of osteoporosis in the lumbar spine and femoral neck increased rapidly within the first year after HT and was detected in 17% and 13% of the patients, respectively. A higher T score before HT was a negative predictor of osteoporosis up to 10 years post-HT in the lumbar spine (HR 0.13; 95% CI 0.063-0.26; P &lt; 0.001) and femoral neck (HR 0.54; 95% CI 0.34-0.85; P &lt; 0.001). Moreover, only 13%, 14%, and 6% of the HT patients received calcium, vitamin D, and/or bisphosphonates before HT. In conclusion, BMD drops significantly during the first postoperative year. Optimization of BMD early among HT candidates, potentially through usage of osteoporosis preventive treatment, may be a future means to prevent osteoporosis late postoperatively.</p>},
  articleno    = {e13477},
  author       = {Löfdahl, Eveline and Söderlund, Carl and Rådegran, Göran},
  issn         = {0902-0063},
  keyword      = {bone mineral density,heart transplantation,osteoporosis,T score},
  language     = {eng},
  month        = {01},
  number       = {3},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Transplantation},
  title        = {Bone mineral density and osteoporosis in heart transplanted patients : A single-center retrospective study at Skåne University Hospital in Lund 1988-2016},
  url          = {http://dx.doi.org/10.1111/ctr.13477},
  volume       = {33},
  year         = {2019},
}