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Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition

Costas, Laura; Lujan-Barroso, Leila; Benavente, Yolanda; Allen, Naomi E.; Amiano, Pilar; Ardanaz, Eva LU ; Besson, Caroline; Boeing, Heiner; Bueno-de-Mesquita, Bas and Cervenka, Iris, et al. (2019) In American Journal of Epidemiology 188(2). p.274-281
Abstract

The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional... (More)

The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.

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American Journal of Epidemiology
volume
188
issue
2
pages
8 pages
publisher
Oxford University Press
external identifiers
  • scopus:85061015182
ISSN
0002-9262
DOI
10.1093/aje/kwy259
language
English
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yes
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c4947602-c9fc-4bbf-81c7-207592b6dc39
date added to LUP
2019-02-11 14:43:32
date last changed
2019-02-19 14:43:39
@article{c4947602-c9fc-4bbf-81c7-207592b6dc39,
  abstract     = {<p>The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.</p>},
  author       = {Costas, Laura and Lujan-Barroso, Leila and Benavente, Yolanda and Allen, Naomi E. and Amiano, Pilar and Ardanaz, Eva and Besson, Caroline and Boeing, Heiner and Bueno-de-Mesquita, Bas and Cervenka, Iris and Fortner, Renée T. and Fournier, Agnès and Gunter, Marc and Harlid, Sophia and Huerta, José María and Jerkeman, Mats and Jirström, Karin and Kaaks, Rudolf and Karakatsani, Anna and Khaw, Kay Tee and Kotanidou, Anastasia and Lund, Eiliv and Masala, Giovanna and Mattiello, Amalia and Melin, Beatrice and Menéndez, Virginia and Murphy, Neil and Nieters, Alexandra and Overvad, Kim and Riboli, Elio and Sacerdote, Carlotta and Sánchez, Maria Jose and Schmidt, Julie A. and Sieri, Sabina and Tjønneland, Anne and Trichopoulou, Antonia and Tumino, Rosario and Vermeulen, Roel and Weiderpass, Elisabete and de Sanjosé, Silvia and Agudo, Antonio and Casabonne, Delphine},
  issn         = {0002-9262},
  language     = {eng},
  number       = {2},
  pages        = {274--281},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1093/aje/kwy259},
  volume       = {188},
  year         = {2019},
}