Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Homocysteine is related to neopterin and endothelin-1 in plasma of subjects with disturbed glucose metabolism and reference subjects

Gottsäter, A. LU ; Anwaar, I. LU ; Eriksson, K. F. LU ; Mattiasson, I. LU and Lindgärde, F. LU (2000) In Angiology 51(6). p.489-497
Abstract

Hyperhomocysteinemia is an independent risk factor for vascular disease. In order to evaluate relations between hyperhomocysteinemia and endothelial and leukocyte function, the investigators related homocysteine to indices of endothelial function (plasma endothelin-1 [p-ET-1] and intraplatelet levels of the nitric oxide [NO] and prostacyclin mediators 3'-5' guanosine monophosphate [cGMP] and cyclic 3'-5' adenosine monophosphate [cAMP]) and the monocyte-derived inflammatory mediator neopterin in 168 men (mean age 69, range 49-72 years) with disturbed glucose metabolism and a reference group of 52 male subjects (mean age 70, range 61-79 years). Among the 168 patients with disturbed glucose metabolism plasma (p)-homocysteine correlated-... (More)

Hyperhomocysteinemia is an independent risk factor for vascular disease. In order to evaluate relations between hyperhomocysteinemia and endothelial and leukocyte function, the investigators related homocysteine to indices of endothelial function (plasma endothelin-1 [p-ET-1] and intraplatelet levels of the nitric oxide [NO] and prostacyclin mediators 3'-5' guanosine monophosphate [cGMP] and cyclic 3'-5' adenosine monophosphate [cAMP]) and the monocyte-derived inflammatory mediator neopterin in 168 men (mean age 69, range 49-72 years) with disturbed glucose metabolism and a reference group of 52 male subjects (mean age 70, range 61-79 years). Among the 168 patients with disturbed glucose metabolism plasma (p)-homocysteine correlated- significantly with age (r = 0.20; p<0.01), glycosylated hemoglobin (HbA(1c)) (r = 0.17; p<0.05), triglycerides (r = 0.20; p<0.05), intraplatelet GMP (r = 0.16; p<0.05), p-ET-1 (r = 0.21; p<0.05), and p-neopterin (r = 0.31; p<0.001). The correlation between p-homocysteine and p-ET-1 persisted (p<0.01) in multiple regression analysis. Among the 52 reference subjects p- homocysteine correlated significantly with p-ET-1 (r = 0.32; p<0.05) and p- neopterin (r = 0.37; p<0.01). The correlation between p-homocysteine and p- neopterin persisted (p<0.05) in multiple regression analysis. In conclusion, homocysteine is related to neopterin and endothelin-1 in plasma of subjects with disturbed glucose metabolism and in reference subjects, suggesting that homocysteine exerts its deleterious effects on vascular function through interference with endothelial and leukocyte function.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Angiology
volume
51
issue
6
pages
489 - 497
publisher
SAGE Publications
external identifiers
  • scopus:0342733456
  • pmid:10870858
ISSN
0003-3197
DOI
10.1177/000331970005100606
language
English
LU publication?
yes
id
c52202bb-e02e-4c0e-b941-6f4aa84ad495
date added to LUP
2020-12-11 14:21:09
date last changed
2021-02-17 05:27:52
@article{c52202bb-e02e-4c0e-b941-6f4aa84ad495,
  abstract     = {<p>Hyperhomocysteinemia is an independent risk factor for vascular disease. In order to evaluate relations between hyperhomocysteinemia and endothelial and leukocyte function, the investigators related homocysteine to indices of endothelial function (plasma endothelin-1 [p-ET-1] and intraplatelet levels of the nitric oxide [NO] and prostacyclin mediators 3'-5' guanosine monophosphate [cGMP] and cyclic 3'-5' adenosine monophosphate [cAMP]) and the monocyte-derived inflammatory mediator neopterin in 168 men (mean age 69, range 49-72 years) with disturbed glucose metabolism and a reference group of 52 male subjects (mean age 70, range 61-79 years). Among the 168 patients with disturbed glucose metabolism plasma (p)-homocysteine correlated- significantly with age (r = 0.20; p&lt;0.01), glycosylated hemoglobin (HbA(1c)) (r = 0.17; p&lt;0.05), triglycerides (r = 0.20; p&lt;0.05), intraplatelet GMP (r = 0.16; p&lt;0.05), p-ET-1 (r = 0.21; p&lt;0.05), and p-neopterin (r = 0.31; p&lt;0.001). The correlation between p-homocysteine and p-ET-1 persisted (p&lt;0.01) in multiple regression analysis. Among the 52 reference subjects p- homocysteine correlated significantly with p-ET-1 (r = 0.32; p&lt;0.05) and p- neopterin (r = 0.37; p&lt;0.01). The correlation between p-homocysteine and p- neopterin persisted (p&lt;0.05) in multiple regression analysis. In conclusion, homocysteine is related to neopterin and endothelin-1 in plasma of subjects with disturbed glucose metabolism and in reference subjects, suggesting that homocysteine exerts its deleterious effects on vascular function through interference with endothelial and leukocyte function.</p>},
  author       = {Gottsäter, A. and Anwaar, I. and Eriksson, K. F. and Mattiasson, I. and Lindgärde, F.},
  issn         = {0003-3197},
  language     = {eng},
  number       = {6},
  pages        = {489--497},
  publisher    = {SAGE Publications},
  series       = {Angiology},
  title        = {Homocysteine is related to neopterin and endothelin-1 in plasma of subjects with disturbed glucose metabolism and reference subjects},
  url          = {http://dx.doi.org/10.1177/000331970005100606},
  doi          = {10.1177/000331970005100606},
  volume       = {51},
  year         = {2000},
}