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Serrated polyps–a concealed but prevalent precursor of colorectal cancer

Thorlacius, Henrik LU ; Takeuchi, Yoji; Kanesaka, Takashi; Ljungberg, Otto LU ; Uedo, Noriya and Toth, Ervin LU (2017) In Scandinavian Journal of Gastroenterology 52(6-7). p.654-661
Abstract

Serrated polyps have long been considered to lack malignant potential but accumulating data suggest that these lesions may cause up to one-third of all sporadic colorectal cancer. Serrated polyps are classified into three subtypes, including sessile serrated adenomas/polyps (SSA/Ps), traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). SSA/P and TSA harbour malignant potential but TSA represents only 1–2%, wheras SSA/P constitute up to 20% of all serrated lesions. HPs are most common (80%) of all serrated polyps but are considered to have a low potential of developing colorectal cancer. Due to their subtle appearence, detection and removal of serrated polyps pose a major challenge to endoscopists. Considering that... (More)

Serrated polyps have long been considered to lack malignant potential but accumulating data suggest that these lesions may cause up to one-third of all sporadic colorectal cancer. Serrated polyps are classified into three subtypes, including sessile serrated adenomas/polyps (SSA/Ps), traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). SSA/P and TSA harbour malignant potential but TSA represents only 1–2%, wheras SSA/P constitute up to 20% of all serrated lesions. HPs are most common (80%) of all serrated polyps but are considered to have a low potential of developing colorectal cancer. Due to their subtle appearence, detection and removal of serrated polyps pose a major challenge to endoscopists. Considering that precancerous serrated polyps are predominately located in the right colon could explain why interval cancers most frequently appear in the proximal colon and why colonoscopy is less protective against colon cancer in the proximal compared to the distal colon. Despite the significant impact on colorectal cancer incidence, the aetiology, incidence, prevalence, and natural history of serrated polyps is incompletely known. To effectively detect, remove, and follow-up serrated polyps, endoscopists and pathologists should be well-informed about serrated polyps. This review highlights colorectal serrated polyps in terms of biology, types, diagnosis, therapy, and follow-up.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
colonoscopy, Colorectal cancer, hyperplastic, malignant, polyps
in
Scandinavian Journal of Gastroenterology
volume
52
issue
6-7
pages
654 - 661
publisher
Taylor & Francis
external identifiers
  • scopus:85018657326
  • wos:000399808100007
ISSN
0036-5521
DOI
10.1080/00365521.2017.1298154
language
English
LU publication?
yes
id
c551f0e3-f284-46f6-8e2d-bb75d2b31aaa
date added to LUP
2017-06-07 14:55:24
date last changed
2018-01-07 12:06:24
@article{c551f0e3-f284-46f6-8e2d-bb75d2b31aaa,
  abstract     = {<p>Serrated polyps have long been considered to lack malignant potential but accumulating data suggest that these lesions may cause up to one-third of all sporadic colorectal cancer. Serrated polyps are classified into three subtypes, including sessile serrated adenomas/polyps (SSA/Ps), traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). SSA/P and TSA harbour malignant potential but TSA represents only 1–2%, wheras SSA/P constitute up to 20% of all serrated lesions. HPs are most common (80%) of all serrated polyps but are considered to have a low potential of developing colorectal cancer. Due to their subtle appearence, detection and removal of serrated polyps pose a major challenge to endoscopists. Considering that precancerous serrated polyps are predominately located in the right colon could explain why interval cancers most frequently appear in the proximal colon and why colonoscopy is less protective against colon cancer in the proximal compared to the distal colon. Despite the significant impact on colorectal cancer incidence, the aetiology, incidence, prevalence, and natural history of serrated polyps is incompletely known. To effectively detect, remove, and follow-up serrated polyps, endoscopists and pathologists should be well-informed about serrated polyps. This review highlights colorectal serrated polyps in terms of biology, types, diagnosis, therapy, and follow-up.</p>},
  author       = {Thorlacius, Henrik and Takeuchi, Yoji and Kanesaka, Takashi and Ljungberg, Otto and Uedo, Noriya and Toth, Ervin},
  issn         = {0036-5521},
  keyword      = {colonoscopy,Colorectal cancer,hyperplastic,malignant,polyps},
  language     = {eng},
  month        = {07},
  number       = {6-7},
  pages        = {654--661},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Serrated polyps–a concealed but prevalent precursor of colorectal cancer},
  url          = {http://dx.doi.org/10.1080/00365521.2017.1298154},
  volume       = {52},
  year         = {2017},
}