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Reovirus type 1 associated with meningitis

Johansson, Hugo LU ; Sveger, Tomas LU ; Ahlfors, Karin ; Ekstrand, Jarl and Svensson, Lennart (1996) In Scandinavian Journal of Infectious Diseases 28(2). p.117-120
Abstract
A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
28
issue
2
pages
117 - 120
publisher
Informa Healthcare
external identifiers
  • pmid:8792475
  • scopus:0030001319
ISSN
1651-1980
DOI
10.3109/00365549609049060
language
English
LU publication?
yes
id
c5624b62-7e1b-4573-9008-80abf1c26859 (old id 1110216)
date added to LUP
2016-04-01 16:31:49
date last changed
2022-01-28 20:23:09
@article{c5624b62-7e1b-4573-9008-80abf1c26859,
  abstract     = {{A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.}},
  author       = {{Johansson, Hugo and Sveger, Tomas and Ahlfors, Karin and Ekstrand, Jarl and Svensson, Lennart}},
  issn         = {{1651-1980}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{117--120}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Infectious Diseases}},
  title        = {{Reovirus type 1 associated with meningitis}},
  url          = {{http://dx.doi.org/10.3109/00365549609049060}},
  doi          = {{10.3109/00365549609049060}},
  volume       = {{28}},
  year         = {{1996}},
}