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Benzochromenes from the roots of Bourreria pulchra

Erosa-Rejon, Gilda J. ; Yam-Puc, Alejandro ; Chan-Bacab, Manuel J. ; Gimenez-Turbax, Alberto ; Salamanca, Efrain ; Pena-Rodriguez, Luis M. and Sterner, Olov LU (2010) In Phytochemistry Letters 3(1). p.9-12
Abstract
Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bourreria pulchra, Boraginaceae, Benzochromene, Antiprotozoal, Leishmania mexicana, Trypanosoma cruzi
in
Phytochemistry Letters
volume
3
issue
1
pages
9 - 12
publisher
Elsevier
external identifiers
  • wos:000287846800002
  • scopus:77949263050
ISSN
1874-3900
DOI
10.1016/j.phytol.2009.10.002
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
c5789915-9796-40da-9c59-f03b9e263aa5 (old id 1859571)
date added to LUP
2016-04-01 10:31:11
date last changed
2025-10-14 13:18:08
@article{c5789915-9796-40da-9c59-f03b9e263aa5,
  abstract     = {{Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.}},
  author       = {{Erosa-Rejon, Gilda J. and Yam-Puc, Alejandro and Chan-Bacab, Manuel J. and Gimenez-Turbax, Alberto and Salamanca, Efrain and Pena-Rodriguez, Luis M. and Sterner, Olov}},
  issn         = {{1874-3900}},
  keywords     = {{Bourreria pulchra; Boraginaceae; Benzochromene; Antiprotozoal; Leishmania mexicana; Trypanosoma cruzi}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{9--12}},
  publisher    = {{Elsevier}},
  series       = {{Phytochemistry Letters}},
  title        = {{Benzochromenes from the roots of Bourreria pulchra}},
  url          = {{http://dx.doi.org/10.1016/j.phytol.2009.10.002}},
  doi          = {{10.1016/j.phytol.2009.10.002}},
  volume       = {{3}},
  year         = {{2010}},
}