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The temporal relationship between poor lung function and the risk of diabetes

Zaigham, Suneela LU ; Nilsson, Peter M. LU ; Wollmer, Per LU and Engström, Gunnar LU (2016) In BMC Pulmonary Medicine 16(1).
Abstract

Background: The association between impaired lung function and diabetes risk has been established in the past, however the temporal and causal relationships between the two remain unclear. We assessed the relationship between baseline FEV1 and FVC and risk of incident diabetes at different time intervals for participants in the Malmö Preventive Project cohort. Methods: Baseline lung function was assessed in 20,295 men and 7416 women during 1974-1992; mean age 43.4 ± 6.6 and 47.6 ± 7.8, respectively. Sex-specific quartiles of FEV1%predicted and FVC%predicted were created (Q4 = highest; reference). Follow-up time was divided into 10-year time intervals from baseline examination. Cox proportional hazards regression... (More)

Background: The association between impaired lung function and diabetes risk has been established in the past, however the temporal and causal relationships between the two remain unclear. We assessed the relationship between baseline FEV1 and FVC and risk of incident diabetes at different time intervals for participants in the Malmö Preventive Project cohort. Methods: Baseline lung function was assessed in 20,295 men and 7416 women during 1974-1992; mean age 43.4 ± 6.6 and 47.6 ± 7.8, respectively. Sex-specific quartiles of FEV1%predicted and FVC%predicted were created (Q4 = highest; reference). Follow-up time was divided into 10-year time intervals from baseline examination. Cox proportional hazards regression was used to assess the incidence of diabetes according to quartiles of FEV1 and FVC%predicted, after adjustments for baseline glucose and potential confounding factors. Results: Over 37-years' follow-up there were 3753 and 993 incident diabetes events in men and women, respectively. When comparing FEV1%predicted in men (Q1 vs. Q4), the HR for diabetes was 1.64 (1.21-2.22) for events 30 years after baseline. A broadly similar pattern was seen for FVC%predicted and for women. Conclusions: Low FEV1 precedes and significantly predicts future diabetes. This risk is still significant many years after the baseline FEV1 measurement in middle-aged men. These results suggest that there is a relationship between impaired lung function and diabetes risk beyond the effects of hyperglycemia on lung function.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diabetes, Incidence, Lung function
in
BMC Pulmonary Medicine
volume
16
issue
1
article number
75
publisher
BioMed Central (BMC)
external identifiers
  • scopus:84969221070
  • pmid:27165091
  • wos:000375959200006
ISSN
1471-2466
DOI
10.1186/s12890-016-0227-z
language
English
LU publication?
yes
id
c59caa61-3539-4b7a-ab9f-57bb1a17c7fd
date added to LUP
2016-06-02 16:21:16
date last changed
2024-12-14 05:25:19
@article{c59caa61-3539-4b7a-ab9f-57bb1a17c7fd,
  abstract     = {{<p>Background: The association between impaired lung function and diabetes risk has been established in the past, however the temporal and causal relationships between the two remain unclear. We assessed the relationship between baseline FEV<sub>1</sub> and FVC and risk of incident diabetes at different time intervals for participants in the Malmö Preventive Project cohort. Methods: Baseline lung function was assessed in 20,295 men and 7416 women during 1974-1992; mean age 43.4 ± 6.6 and 47.6 ± 7.8, respectively. Sex-specific quartiles of FEV<sub>1</sub>%predicted and FVC%predicted were created (Q4 = highest; reference). Follow-up time was divided into 10-year time intervals from baseline examination. Cox proportional hazards regression was used to assess the incidence of diabetes according to quartiles of FEV<sub>1</sub> and FVC%predicted, after adjustments for baseline glucose and potential confounding factors. Results: Over 37-years' follow-up there were 3753 and 993 incident diabetes events in men and women, respectively. When comparing FEV<sub>1</sub>%predicted in men (Q1 vs. Q4), the HR for diabetes was 1.64 (1.21-2.22) for events 30 years after baseline. A broadly similar pattern was seen for FVC%predicted and for women. Conclusions: Low FEV<sub>1</sub> precedes and significantly predicts future diabetes. This risk is still significant many years after the baseline FEV<sub>1</sub> measurement in middle-aged men. These results suggest that there is a relationship between impaired lung function and diabetes risk beyond the effects of hyperglycemia on lung function.</p>}},
  author       = {{Zaigham, Suneela and Nilsson, Peter M. and Wollmer, Per and Engström, Gunnar}},
  issn         = {{1471-2466}},
  keywords     = {{Diabetes; Incidence; Lung function}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Pulmonary Medicine}},
  title        = {{The temporal relationship between poor lung function and the risk of diabetes}},
  url          = {{http://dx.doi.org/10.1186/s12890-016-0227-z}},
  doi          = {{10.1186/s12890-016-0227-z}},
  volume       = {{16}},
  year         = {{2016}},
}