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The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species : Results from a randomized crossover intervention study in healthy adults

Schmedes, Mette; Balderas, Claudia LU ; Aadland, Eli Kristin; Jacques, Hélène; Lavigne, Charles; Graff, Ingvild Eide; Eng, Øyvin; Holthe, Asle; Mellgren, Gunnar and Young, Jette Feveile, et al. (2018) In Nutrients 10(5).
Abstract

The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial serum metabolites and lipid species. In a randomized controlled trial with crossover design, healthy adults (n = 20) underwent a 4-week intervention with two balanced diets that varied mainly in protein source (lean-seafood versus non-seafood proteins). Nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry analyses were applied to examine the effects of the two diets on serum metabolites. In the fasting state, the lean-seafood diet period, as opposed to the non-seafood diet period,... (More)

The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial serum metabolites and lipid species. In a randomized controlled trial with crossover design, healthy adults (n = 20) underwent a 4-week intervention with two balanced diets that varied mainly in protein source (lean-seafood versus non-seafood proteins). Nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry analyses were applied to examine the effects of the two diets on serum metabolites. In the fasting state, the lean-seafood diet period, as opposed to the non-seafood diet period, significantly decreased the serum levels of isoleucine and valine, and during the postprandial state, a decreased level of lactate and increased levels of citrate and trimethylamine N-oxide were observed. The non-seafood diet significantly increased the fasting level of 26 lipid species including ceramides 18:1/14:0 and 18:1/23:0 and lysophosphatidylcholines 20:4 and 22:5, as compared to the lean-seafood diet. Thus, the lean-seafood diet decreased circulating isoleucine and valine levels, whereas the non-seafood diet elevated the levels of certain ceramides, metabolites that are associated with insulin-resistance.

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Contribution to journal
publication status
published
subject
keywords
Metabolism, Postprandial, Seafood protein, TMAO
in
Nutrients
volume
10
issue
5
publisher
MDPI AG
external identifiers
  • scopus:85046851009
ISSN
2072-6643
DOI
10.3390/nu10050598
language
English
LU publication?
yes
id
c5ae7d69-28eb-4ee5-b9e1-4a0bde07e0b2
date added to LUP
2018-05-23 14:15:24
date last changed
2019-05-21 04:06:06
@article{c5ae7d69-28eb-4ee5-b9e1-4a0bde07e0b2,
  abstract     = {<p>The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial serum metabolites and lipid species. In a randomized controlled trial with crossover design, healthy adults (n = 20) underwent a 4-week intervention with two balanced diets that varied mainly in protein source (lean-seafood versus non-seafood proteins). Nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry analyses were applied to examine the effects of the two diets on serum metabolites. In the fasting state, the lean-seafood diet period, as opposed to the non-seafood diet period, significantly decreased the serum levels of isoleucine and valine, and during the postprandial state, a decreased level of lactate and increased levels of citrate and trimethylamine N-oxide were observed. The non-seafood diet significantly increased the fasting level of 26 lipid species including ceramides 18:1/14:0 and 18:1/23:0 and lysophosphatidylcholines 20:4 and 22:5, as compared to the lean-seafood diet. Thus, the lean-seafood diet decreased circulating isoleucine and valine levels, whereas the non-seafood diet elevated the levels of certain ceramides, metabolites that are associated with insulin-resistance.</p>},
  articleno    = {598},
  author       = {Schmedes, Mette and Balderas, Claudia and Aadland, Eli Kristin and Jacques, Hélène and Lavigne, Charles and Graff, Ingvild Eide and Eng, Øyvin and Holthe, Asle and Mellgren, Gunnar and Young, Jette Feveile and Sundekilde, Ulrik Kræmer and Liaset, Bjørn and Bertram, Hanne Christine},
  issn         = {2072-6643},
  keyword      = {Metabolism,Postprandial,Seafood protein,TMAO},
  language     = {eng},
  month        = {05},
  number       = {5},
  publisher    = {MDPI AG},
  series       = {Nutrients},
  title        = {The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species : Results from a randomized crossover intervention study in healthy adults},
  url          = {http://dx.doi.org/10.3390/nu10050598},
  volume       = {10},
  year         = {2018},
}