Liposarcoma: a population-based epidemiologic and prognostic study of features of 43 patients, including tumor DNA content
(1993) In International Journal of Cancer 55(4). p.541-546- Abstract
- Different conceptions exist regarding the epidemiology and prognosis of liposarcoma, and several classification systems are in use. We analyzed a population-based, 25-year series of 43 patients with liposarcoma of the extremity or trunk wall. Follow-up was complete. The annual incidence was 0.12/10(5). The thigh was the most common location. One of 6 tumors was subcutaneous. Deep-seated tumors were larger than s.c. tumors. Among the 42 surgically treated patients, grade II (4-grade scale) was the most common malignancy grade. Four tumors were well-differentiated, 24 were predominantly myxoid, 4 predominantly round-cell, and 10 were predominantly of pleomorphic type. The 5-year metastasis-free survival rate was 69%. By univariate analysis... (More)
- Different conceptions exist regarding the epidemiology and prognosis of liposarcoma, and several classification systems are in use. We analyzed a population-based, 25-year series of 43 patients with liposarcoma of the extremity or trunk wall. Follow-up was complete. The annual incidence was 0.12/10(5). The thigh was the most common location. One of 6 tumors was subcutaneous. Deep-seated tumors were larger than s.c. tumors. Among the 42 surgically treated patients, grade II (4-grade scale) was the most common malignancy grade. Four tumors were well-differentiated, 24 were predominantly myxoid, 4 predominantly round-cell, and 10 were predominantly of pleomorphic type. The 5-year metastasis-free survival rate was 69%. By univariate analysis increasing malignancy grade, tumor necrosis, vascular invasion, mitotic count, subtype other than well-differentiated, and high cellularity were prognostic for metastatic disease. However, in the multivariate analysis only tumor necrosis was an independent risk factor. Tumor necrosis should be considered when prognosis of liposarcoma of the extremity and trunk wall is evaluated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107012
- author
- Gustafson, Pelle LU ; Rydholm, Anders LU ; Willén, Helena ; Baldetorp, Bo LU ; Fernö, Mårten LU and Åkerman, Måns LU
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Cancer
- volume
- 55
- issue
- 4
- pages
- 541 - 546
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:8406979
- scopus:0027438514
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.2910550404
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000), Department of Orthopaedics (Lund) (013028000)
- id
- c5b1f2c3-0f1d-4501-9fee-91f6bf16356e (old id 1107012)
- date added to LUP
- 2016-04-01 12:06:06
- date last changed
- 2021-01-03 03:26:48
@article{c5b1f2c3-0f1d-4501-9fee-91f6bf16356e,
abstract = {{Different conceptions exist regarding the epidemiology and prognosis of liposarcoma, and several classification systems are in use. We analyzed a population-based, 25-year series of 43 patients with liposarcoma of the extremity or trunk wall. Follow-up was complete. The annual incidence was 0.12/10(5). The thigh was the most common location. One of 6 tumors was subcutaneous. Deep-seated tumors were larger than s.c. tumors. Among the 42 surgically treated patients, grade II (4-grade scale) was the most common malignancy grade. Four tumors were well-differentiated, 24 were predominantly myxoid, 4 predominantly round-cell, and 10 were predominantly of pleomorphic type. The 5-year metastasis-free survival rate was 69%. By univariate analysis increasing malignancy grade, tumor necrosis, vascular invasion, mitotic count, subtype other than well-differentiated, and high cellularity were prognostic for metastatic disease. However, in the multivariate analysis only tumor necrosis was an independent risk factor. Tumor necrosis should be considered when prognosis of liposarcoma of the extremity and trunk wall is evaluated.}},
author = {{Gustafson, Pelle and Rydholm, Anders and Willén, Helena and Baldetorp, Bo and Fernö, Mårten and Åkerman, Måns}},
issn = {{0020-7136}},
language = {{eng}},
number = {{4}},
pages = {{541--546}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Liposarcoma: a population-based epidemiologic and prognostic study of features of 43 patients, including tumor DNA content}},
url = {{http://dx.doi.org/10.1002/ijc.2910550404}},
doi = {{10.1002/ijc.2910550404}},
volume = {{55}},
year = {{1993}},
}