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Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy

Wulff, Nille B. ; Dalton, Susanne O. ; Wessel, Irene ; Arenaz Búa, Beatriz LU ; Löfhede, Helena ; Hammerlid, Eva ; Kjaer, Trille K. ; Godballe, Christian ; Kjærgaard, Thomas and Homøe, Preben (2022) In Laryngoscope 132(5). p.980-988
Abstract

Objectives/Hypothesis: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects. Study Design: Cross-sectional study. Methods: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Results:... (More)

Objectives/Hypothesis: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects. Study Design: Cross-sectional study. Methods: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Results: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score. Conclusion: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL. Level of Evidence: 3 Laryngoscope, 2021.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
depression, dysphagia, health-related quality of life, Total laryngectomy, voice problems
in
Laryngoscope
volume
132
issue
5
pages
980 - 988
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:34490903
  • scopus:85114472353
ISSN
0023-852X
DOI
10.1002/lary.29857
language
English
LU publication?
yes
id
c5bf2352-7fc9-4fae-beb8-731657faba52
date added to LUP
2021-12-09 15:20:28
date last changed
2024-11-04 12:45:33
@article{c5bf2352-7fc9-4fae-beb8-731657faba52,
  abstract     = {{<p>Objectives/Hypothesis: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects. Study Design: Cross-sectional study. Methods: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&amp;N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Results: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score. Conclusion: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL. Level of Evidence: 3 Laryngoscope, 2021.</p>}},
  author       = {{Wulff, Nille B. and Dalton, Susanne O. and Wessel, Irene and Arenaz Búa, Beatriz and Löfhede, Helena and Hammerlid, Eva and Kjaer, Trille K. and Godballe, Christian and Kjærgaard, Thomas and Homøe, Preben}},
  issn         = {{0023-852X}},
  keywords     = {{depression; dysphagia; health-related quality of life; Total laryngectomy; voice problems}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{980--988}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Laryngoscope}},
  title        = {{Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy}},
  url          = {{http://dx.doi.org/10.1002/lary.29857}},
  doi          = {{10.1002/lary.29857}},
  volume       = {{132}},
  year         = {{2022}},
}