Second-hand smoke exposure modulates plasma proteins linked to detoxification, inflammation and atherothrombosis
Neves, Sofia ; Pacheco, Solange A. ; Vaz, Fátima ; Valentim-Coelho, Cristina ; Saraiva, Joana ; James, Peter LU
; Simões, Tânia
and Penque, Deborah
(2025)
In Environmental Toxicology and Pharmacology
120.
- Abstract
Chronic exposure to second-hand smoke (SHS) contributes to the development of health issues, including cancer and cardiovascular diseases. Molecular mechanisms underlying SHS-related diseases remain poorly understood, highlighting the need for reliable risk assessment biomarkers. Herein, we demonstrate that the plasma proteome of individuals exposed to SHS undergoes significant modulation. Butyrylcholinesterase (BChE) and Vitamin D-binding protein (GC) that are involved in the physiological response to circulating toxic substances, as well as key mediators of systemic inflammation, including Complement C1r subcomponent (C1R), Complement C1q subcomponent subunit C (C1QC), Histidine-rich glycoprotein (HRG), and Vitamin K-dependent protein... (More)
Chronic exposure to second-hand smoke (SHS) contributes to the development of health issues, including cancer and cardiovascular diseases. Molecular mechanisms underlying SHS-related diseases remain poorly understood, highlighting the need for reliable risk assessment biomarkers. Herein, we demonstrate that the plasma proteome of individuals exposed to SHS undergoes significant modulation. Butyrylcholinesterase (BChE) and Vitamin D-binding protein (GC) that are involved in the physiological response to circulating toxic substances, as well as key mediators of systemic inflammation, including Complement C1r subcomponent (C1R), Complement C1q subcomponent subunit C (C1QC), Histidine-rich glycoprotein (HRG), and Vitamin K-dependent protein S (PROS1), were found to be significantly modulated in SHS-exposed individuals. Moreover, strong indicators of a pro-atherothrombotic response such Apolipoprotein A-IV (APOA4) and Alpha-2-antiplasmin (SERPINF2), were also differentially expressed. These findings provide novel insights into the biological pathways linking SHS-exposure to cardiovascular risks, and suggest a panel of candidate proteins with potential utility as SHS-risk assessment biomarkers.
(Less)
- author
- Neves, Sofia
; Pacheco, Solange A.
; Vaz, Fátima
; Valentim-Coelho, Cristina
; Saraiva, Joana
; James, Peter
LU
; Simões, Tânia
and Penque, Deborah
- organization
- publishing date
- 2025-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atherosclerosis, Inflammation, Plasma, Second-hand smoke, Shotgun proteomics, Thrombosis
- in
- Environmental Toxicology and Pharmacology
- volume
- 120
- article number
- 104864
- publisher
- Elsevier
- external identifiers
-
- pmid:41207518
- scopus:105021534058
- ISSN
- 1382-6689
- DOI
- 10.1016/j.etap.2025.104864
- language
- English
- LU publication?
- yes
- id
- c5d1b61e-1f49-46a5-9763-fac05a892923
- date added to LUP
- 2026-01-12 14:11:14
- date last changed
- 2026-06-16 09:21:19
@article{c5d1b61e-1f49-46a5-9763-fac05a892923,
abstract = {{<p>Chronic exposure to second-hand smoke (SHS) contributes to the development of health issues, including cancer and cardiovascular diseases. Molecular mechanisms underlying SHS-related diseases remain poorly understood, highlighting the need for reliable risk assessment biomarkers. Herein, we demonstrate that the plasma proteome of individuals exposed to SHS undergoes significant modulation. Butyrylcholinesterase (BChE) and Vitamin D-binding protein (GC) that are involved in the physiological response to circulating toxic substances, as well as key mediators of systemic inflammation, including Complement C1r subcomponent (C1R), Complement C1q subcomponent subunit C (C1QC), Histidine-rich glycoprotein (HRG), and Vitamin K-dependent protein S (PROS1), were found to be significantly modulated in SHS-exposed individuals. Moreover, strong indicators of a pro-atherothrombotic response such Apolipoprotein A-IV (APOA4) and Alpha-2-antiplasmin (SERPINF2), were also differentially expressed. These findings provide novel insights into the biological pathways linking SHS-exposure to cardiovascular risks, and suggest a panel of candidate proteins with potential utility as SHS-risk assessment biomarkers.</p>}},
author = {{Neves, Sofia and Pacheco, Solange A. and Vaz, Fátima and Valentim-Coelho, Cristina and Saraiva, Joana and James, Peter and Simões, Tânia and Penque, Deborah}},
issn = {{1382-6689}},
keywords = {{Atherosclerosis; Inflammation; Plasma; Second-hand smoke; Shotgun proteomics; Thrombosis}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Environmental Toxicology and Pharmacology}},
title = {{Second-hand smoke exposure modulates plasma proteins linked to detoxification, inflammation and atherothrombosis}},
url = {{http://dx.doi.org/10.1016/j.etap.2025.104864}},
doi = {{10.1016/j.etap.2025.104864}},
volume = {{120}},
year = {{2025}},
}