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An estimate of the worldwide prevalence and disability associated with osteoporotic fractures

Johnell, Olof LU and Kanis, J. A. (2006) In Osteoporosis International 17(12). p.1726-1733
Abstract
Objective The aim of this study was to quantify the global burden of osteoporotic fracture worldwide. Methods The incidence of hip fractures was identified by systematic review and the incidence of osteoporotic fractures was imputed from the incidence of hip fractures in different regions of the world. Excess mortality and disability weights used age- and sex-specific data from Sweden to calculate the Disability Adjusted Life Years (DALYs) lost due to osteoporotic fracture. Results In the year 2000 there were an estimated 9.0 million osteoporotic fractures of which 1.6 million were at the hip, 1.7 million at the forearm and 1.4 million were clinical vertebral fractures. The greatest number of osteoporotic fractures occurred in Europe... (More)
Objective The aim of this study was to quantify the global burden of osteoporotic fracture worldwide. Methods The incidence of hip fractures was identified by systematic review and the incidence of osteoporotic fractures was imputed from the incidence of hip fractures in different regions of the world. Excess mortality and disability weights used age- and sex-specific data from Sweden to calculate the Disability Adjusted Life Years (DALYs) lost due to osteoporotic fracture. Results In the year 2000 there were an estimated 9.0 million osteoporotic fractures of which 1.6 million were at the hip, 1.7 million at the forearm and 1.4 million were clinical vertebral fractures. The greatest number of osteoporotic fractures occurred in Europe (34.8%). The total DALYs lost was 5.8 million of which 51% were accounted for by fractures that occurred in Europe and the Americas. World-wide, osteoporotic fractures accounted for 0.83% of the global burden of non-communicable disease and was 1.75% of the global burden in Europe. In Europe, osteoporotic fractures accounted for more DALYs lost than common cancers with the exception of lung cancer. For chronic musculo-skeletal disorders the DALYs lost in Europe due to osteoporosis (2.0 million) were less than for osteoarthrosis (3.1 million) but greater than for rheumatoid arthritis (1.0 million). Conclusion We conclude that osteoporotic fractures are a significant cause of morbidity and mortality, particularly in the developed countries. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hip fracture, noncommunicable diseases, disability-adjusted life-years, mortality
in
Osteoporosis International
volume
17
issue
12
pages
1726 - 1733
publisher
Springer
external identifiers
  • wos:000241452000003
  • scopus:33750209491
ISSN
1433-2965
DOI
10.1007/s00198-006-0172-4
language
English
LU publication?
yes
id
c60c703c-66cf-444c-a4c1-f92ad9671f29 (old id 685885)
date added to LUP
2008-01-03 13:40:35
date last changed
2018-11-18 04:26:31
@article{c60c703c-66cf-444c-a4c1-f92ad9671f29,
  abstract     = {Objective The aim of this study was to quantify the global burden of osteoporotic fracture worldwide. Methods The incidence of hip fractures was identified by systematic review and the incidence of osteoporotic fractures was imputed from the incidence of hip fractures in different regions of the world. Excess mortality and disability weights used age- and sex-specific data from Sweden to calculate the Disability Adjusted Life Years (DALYs) lost due to osteoporotic fracture. Results In the year 2000 there were an estimated 9.0 million osteoporotic fractures of which 1.6 million were at the hip, 1.7 million at the forearm and 1.4 million were clinical vertebral fractures. The greatest number of osteoporotic fractures occurred in Europe (34.8%). The total DALYs lost was 5.8 million of which 51% were accounted for by fractures that occurred in Europe and the Americas. World-wide, osteoporotic fractures accounted for 0.83% of the global burden of non-communicable disease and was 1.75% of the global burden in Europe. In Europe, osteoporotic fractures accounted for more DALYs lost than common cancers with the exception of lung cancer. For chronic musculo-skeletal disorders the DALYs lost in Europe due to osteoporosis (2.0 million) were less than for osteoarthrosis (3.1 million) but greater than for rheumatoid arthritis (1.0 million). Conclusion We conclude that osteoporotic fractures are a significant cause of morbidity and mortality, particularly in the developed countries.},
  author       = {Johnell, Olof and Kanis, J. A.},
  issn         = {1433-2965},
  keyword      = {hip fracture,noncommunicable diseases,disability-adjusted life-years,mortality},
  language     = {eng},
  number       = {12},
  pages        = {1726--1733},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {An estimate of the worldwide prevalence and disability associated with osteoporotic fractures},
  url          = {http://dx.doi.org/10.1007/s00198-006-0172-4},
  volume       = {17},
  year         = {2006},
}