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Identification of collagen-induced arthritis loci in aged multiparous female mice.

Liljander, Maria LU ; Micha Frisk, Mary-Ann LU ; Andersson, Sara LU ; Andersson, Asa; Holmdahl, Rikard LU and Mattsson, Ragnar LU (2006) In Arthritis Research and Therapy 8(2). p.45-45
Abstract
Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex polygenic disease there is a need for identification of several major disease-controlling genes. Because rheumatoid arthritis particularly affects aged women, we have in the present study identified new genetic regions critical for collagen-induced arthritis by studying aged female mice of a cross between NFR/N and B10.Q (H-2q haplotype). The mice in the present study had different reproductive histories, which did not significantly affect the onset, incidence or severity of the disease. A total of 200 female mice were used in a total genome-wide... (More)
Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex polygenic disease there is a need for identification of several major disease-controlling genes. Because rheumatoid arthritis particularly affects aged women, we have in the present study identified new genetic regions critical for collagen-induced arthritis by studying aged female mice of a cross between NFR/N and B10.Q (H-2q haplotype). The mice in the present study had different reproductive histories, which did not significantly affect the onset, incidence or severity of the disease. A total of 200 female mice were used in a total genome-wide screening with 125 microsatellite markers. We found one new significant quantitative trait locus affecting the arthritis incidence, severity and day of onset on chromosome 11 (denoted Cia40), which colocalizes with a locus controlling pregnancy failure. Furthermore, a quantitative trait locus of suggestive significance associated with the incidence, severity and day of onset was identified on chromosome 1. Finally, a suggestively significant quantitative trait locus associated with collagen type II antibody titers was identified on chromosome 13. This study indicates that several gene loci control arthritis in aged multiparous females, and that at least one of these loci coincides with pregnancy failure. (Less)
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author
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type
Contribution to journal
publication status
published
subject
in
Arthritis Research and Therapy
volume
8
issue
2
pages
45 - 45
publisher
BioMed Central
external identifiers
  • pmid:16507151
  • wos:000237648600017
  • scopus:34247550959
ISSN
1478-6362
DOI
10.1186/ar1901
language
English
LU publication?
yes
id
c62446a4-d3da-4520-9cde-af8455774906 (old id 154898)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16507151&dopt=Abstract
date added to LUP
2007-07-16 15:54:38
date last changed
2019-02-20 04:09:33
@article{c62446a4-d3da-4520-9cde-af8455774906,
  abstract     = {Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex polygenic disease there is a need for identification of several major disease-controlling genes. Because rheumatoid arthritis particularly affects aged women, we have in the present study identified new genetic regions critical for collagen-induced arthritis by studying aged female mice of a cross between NFR/N and B10.Q (H-2q haplotype). The mice in the present study had different reproductive histories, which did not significantly affect the onset, incidence or severity of the disease. A total of 200 female mice were used in a total genome-wide screening with 125 microsatellite markers. We found one new significant quantitative trait locus affecting the arthritis incidence, severity and day of onset on chromosome 11 (denoted Cia40), which colocalizes with a locus controlling pregnancy failure. Furthermore, a quantitative trait locus of suggestive significance associated with the incidence, severity and day of onset was identified on chromosome 1. Finally, a suggestively significant quantitative trait locus associated with collagen type II antibody titers was identified on chromosome 13. This study indicates that several gene loci control arthritis in aged multiparous females, and that at least one of these loci coincides with pregnancy failure.},
  author       = {Liljander, Maria and Micha Frisk, Mary-Ann and Andersson, Sara and Andersson, Asa and Holmdahl, Rikard and Mattsson, Ragnar},
  issn         = {1478-6362},
  language     = {eng},
  number       = {2},
  pages        = {45--45},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {Identification of collagen-induced arthritis loci in aged multiparous female mice.},
  url          = {http://dx.doi.org/10.1186/ar1901},
  volume       = {8},
  year         = {2006},
}