Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure changes
(1989) In Annals of the Rheumatic Diseases 48(4). p.281-286- Abstract
- A method for measuring synovial blood flow changes using the laser Doppler technique is described. Mean blood flow and mean pulse amplitude decreased by 50-70% in relation to the reference level when the intra-articular hydrostatic pressure in effusive knee joints of patients with rheumatoid arthritis was increased. As an increase of intra-articular pressure of as little as 20 mmHg decreased synovial blood flow significantly it is suggested that hypoxia may occur in vivo during joint use in the presence of an effusion. This may be of aetiopathogenetic importance for tissue destruction and the persistence of chronic synovitis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104724
- author
- Geborek, Pierre LU ; Forslind, K LU and Wollheim, Frank LU
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- laser Doppler technique, rheumatoid arthritis
- in
- Annals of the Rheumatic Diseases
- volume
- 48
- issue
- 4
- pages
- 281 - 286
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:2653243
- scopus:0024521138
- ISSN
- 1468-2060
- DOI
- 10.1136/ard.48.4.281
- language
- English
- LU publication?
- yes
- id
- c679cc6a-c51d-4b59-a2ee-4b565cf29058 (old id 1104724)
- date added to LUP
- 2016-04-01 15:47:18
- date last changed
- 2021-08-15 03:46:53
@article{c679cc6a-c51d-4b59-a2ee-4b565cf29058, abstract = {{A method for measuring synovial blood flow changes using the laser Doppler technique is described. Mean blood flow and mean pulse amplitude decreased by 50-70% in relation to the reference level when the intra-articular hydrostatic pressure in effusive knee joints of patients with rheumatoid arthritis was increased. As an increase of intra-articular pressure of as little as 20 mmHg decreased synovial blood flow significantly it is suggested that hypoxia may occur in vivo during joint use in the presence of an effusion. This may be of aetiopathogenetic importance for tissue destruction and the persistence of chronic synovitis.}}, author = {{Geborek, Pierre and Forslind, K and Wollheim, Frank}}, issn = {{1468-2060}}, keywords = {{laser Doppler technique; rheumatoid arthritis}}, language = {{eng}}, number = {{4}}, pages = {{281--286}}, publisher = {{BMJ Publishing Group}}, series = {{Annals of the Rheumatic Diseases}}, title = {{Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure changes}}, url = {{http://dx.doi.org/10.1136/ard.48.4.281}}, doi = {{10.1136/ard.48.4.281}}, volume = {{48}}, year = {{1989}}, }