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Risk of pulmonary embolism and deep venous thrombosis in patients with asthma : A nationwide case-control study from Sweden

Zöller, Bengt LU ; Pirouzifard, Mirnabi LU ; Memon, Ashfaque A. LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2017) In European Respiratory Journal1988-01-01+01:00 49(2).
Abstract

Asthma is associated with an increased risk of pulmonary embolism (PE) but little is known about whether asthma is associated with an increased risk of deep venous thrombosis (DVT). The aim in this study was to determine the risk of the first event of PE, DVT or a combination of PE and DVT in patients with asthma. We conducted this nationwide case-control study using data from Swedish nationwide registries. We included 114 366 Swedish-born patients with a first hospital diagnosis of PE, 76 494 patients with DVT and 6854 patients with both PE and DVT in Sweden between 1981 and 2010. We also included five age-, sexand education-matched population controls. All previous hospital diagnoses of asthma were identified. Conditional logistic... (More)

Asthma is associated with an increased risk of pulmonary embolism (PE) but little is known about whether asthma is associated with an increased risk of deep venous thrombosis (DVT). The aim in this study was to determine the risk of the first event of PE, DVT or a combination of PE and DVT in patients with asthma. We conducted this nationwide case-control study using data from Swedish nationwide registries. We included 114 366 Swedish-born patients with a first hospital diagnosis of PE, 76 494 patients with DVT and 6854 patients with both PE and DVT in Sweden between 1981 and 2010. We also included five age-, sexand education-matched population controls. All previous hospital diagnoses of asthma were identified. Conditional logistic regression was used to compute odds ratios with adjustment for potential confounders. Asthma was associated with an adjusted odds ratio for PE of 1.43 (95% CI 1.37-1.50), for DVT of 1.56 (95% CI 1.47-1.65) and for combined PE and DVT of 1.60 (95% CI 1.32-1.93). Asthma was associated with an increased risk of PE, DVT and combined PE and DVT. Thus, the inflammation conferred by asthma seems to have systemic (and not just local) prothrombotic effects with increased risk of both DVT and PE.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Respiratory Journal1988-01-01+01:00
volume
49
issue
2
publisher
Eur Respiratory Soc
external identifiers
  • scopus:85013435869
  • wos:000397858100010
ISSN
0903-1936
DOI
10.1183/13993003.01014-2016
language
English
LU publication?
yes
id
c69b43e3-f571-4f32-ae07-2337dba4448d
date added to LUP
2017-03-24 11:09:56
date last changed
2018-01-07 11:56:51
@article{c69b43e3-f571-4f32-ae07-2337dba4448d,
  abstract     = {<p>Asthma is associated with an increased risk of pulmonary embolism (PE) but little is known about whether asthma is associated with an increased risk of deep venous thrombosis (DVT). The aim in this study was to determine the risk of the first event of PE, DVT or a combination of PE and DVT in patients with asthma. We conducted this nationwide case-control study using data from Swedish nationwide registries. We included 114 366 Swedish-born patients with a first hospital diagnosis of PE, 76 494 patients with DVT and 6854 patients with both PE and DVT in Sweden between 1981 and 2010. We also included five age-, sexand education-matched population controls. All previous hospital diagnoses of asthma were identified. Conditional logistic regression was used to compute odds ratios with adjustment for potential confounders. Asthma was associated with an adjusted odds ratio for PE of 1.43 (95% CI 1.37-1.50), for DVT of 1.56 (95% CI 1.47-1.65) and for combined PE and DVT of 1.60 (95% CI 1.32-1.93). Asthma was associated with an increased risk of PE, DVT and combined PE and DVT. Thus, the inflammation conferred by asthma seems to have systemic (and not just local) prothrombotic effects with increased risk of both DVT and PE.</p>},
  articleno    = {1601014},
  author       = {Zöller, Bengt and Pirouzifard, Mirnabi and Memon, Ashfaque A. and Sundquist, Jan and Sundquist, Kristina},
  issn         = {0903-1936},
  language     = {eng},
  month        = {02},
  number       = {2},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal1988-01-01+01:00},
  title        = {Risk of pulmonary embolism and deep venous thrombosis in patients with asthma : A nationwide case-control study from Sweden},
  url          = {http://dx.doi.org/10.1183/13993003.01014-2016},
  volume       = {49},
  year         = {2017},
}