Using Curvature Power to Map the Domain of Inverse Micellar Cubic Phases : The Case of Aliphatic Aldehydes in 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
(2017) In Langmuir 33(44). p.12804-12813- Abstract
Oxylipins, or fatty aldehydes, are a class of molecules produced from membrane lipids as a result of oxidative stress or enzyme-mediated peroxidation. Here we report the effects of two biologically important fatty aldehydes, trans,trans-2,4-decanedienal (DD) and cis-11-hexadecenal (HD), on the phase behavior of the lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) in water. We compare the phase behavior of DD/DOPE and HD/DOPE mixtures to the phase behavior of oleic acid/DOPE mixtures and show that DD, HD, and oleic acid have similar effects on the phase diagrams of DOPE. Notably, both DD and HD, like oleic acid, induce the formation of Fd3m inverse micellar cubic phases in DOPE/water mixtures. This is the first time that Fd3m... (More)
Oxylipins, or fatty aldehydes, are a class of molecules produced from membrane lipids as a result of oxidative stress or enzyme-mediated peroxidation. Here we report the effects of two biologically important fatty aldehydes, trans,trans-2,4-decanedienal (DD) and cis-11-hexadecenal (HD), on the phase behavior of the lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) in water. We compare the phase behavior of DD/DOPE and HD/DOPE mixtures to the phase behavior of oleic acid/DOPE mixtures and show that DD, HD, and oleic acid have similar effects on the phase diagrams of DOPE. Notably, both DD and HD, like oleic acid, induce the formation of Fd3m inverse micellar cubic phases in DOPE/water mixtures. This is the first time that Fd3m phases in fatty aldehyde-containing mixtures have been reported. We assess the effects of DD, HD, and oleic acid on DOPE in terms of lipid spontaneous curvatures and propose a method to predict the formation of Fd3m phases from the curvature power of amphiphiles. This methodology predicts that Fd3m phases will become stable if the spontaneous curvature of a lipid mixture is -0.48 ± 0.05 nm-1 or less.
(Less)
- author
- Burrell, Jamie ; Dymond, Marcus K. ; Gillams, Richard J. ; Parker, Duncan J. ; Langley, G. John ; Labrador, Ana LU ; Nylander, Tommy LU and Attard, George S.
- organization
- publishing date
- 2017-11-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langmuir
- volume
- 33
- issue
- 44
- pages
- 10 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:85033385832
- pmid:28981289
- wos:000414887100029
- ISSN
- 0743-7463
- DOI
- 10.1021/acs.langmuir.7b02998
- language
- English
- LU publication?
- yes
- id
- c6c34403-e722-4851-b747-02ead17ee766
- date added to LUP
- 2017-11-20 10:54:18
- date last changed
- 2024-06-10 03:43:40
@article{c6c34403-e722-4851-b747-02ead17ee766, abstract = {{<p>Oxylipins, or fatty aldehydes, are a class of molecules produced from membrane lipids as a result of oxidative stress or enzyme-mediated peroxidation. Here we report the effects of two biologically important fatty aldehydes, trans,trans-2,4-decanedienal (DD) and cis-11-hexadecenal (HD), on the phase behavior of the lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) in water. We compare the phase behavior of DD/DOPE and HD/DOPE mixtures to the phase behavior of oleic acid/DOPE mixtures and show that DD, HD, and oleic acid have similar effects on the phase diagrams of DOPE. Notably, both DD and HD, like oleic acid, induce the formation of Fd3m inverse micellar cubic phases in DOPE/water mixtures. This is the first time that Fd3m phases in fatty aldehyde-containing mixtures have been reported. We assess the effects of DD, HD, and oleic acid on DOPE in terms of lipid spontaneous curvatures and propose a method to predict the formation of Fd3m phases from the curvature power of amphiphiles. This methodology predicts that Fd3m phases will become stable if the spontaneous curvature of a lipid mixture is -0.48 ± 0.05 nm<sup>-1</sup> or less.</p>}}, author = {{Burrell, Jamie and Dymond, Marcus K. and Gillams, Richard J. and Parker, Duncan J. and Langley, G. John and Labrador, Ana and Nylander, Tommy and Attard, George S.}}, issn = {{0743-7463}}, language = {{eng}}, month = {{11}}, number = {{44}}, pages = {{12804--12813}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Langmuir}}, title = {{Using Curvature Power to Map the Domain of Inverse Micellar Cubic Phases : The Case of Aliphatic Aldehydes in 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine}}, url = {{http://dx.doi.org/10.1021/acs.langmuir.7b02998}}, doi = {{10.1021/acs.langmuir.7b02998}}, volume = {{33}}, year = {{2017}}, }