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Lipoprotein deficient serum stimulates the uptake of chylomicron remnants in cultured hepatocytes

Jensen, Elmo ; Florén, Claes-Henrik LU and Nilsson, Åke LU (1988) In Scandinavian Journal of Clinical & Laboratory Investigation 48(6). p.553-556
Abstract (Swedish)
Rat hepatocyte monolayers were cultured in the presence of 1-10% lipoprotein-deficient foetal calf serum. This increased the uptake and degradation of chylomicron remnant cholesteryl ester significantly. The increase occurred at all cell densities, i.e. also with less dense cultures where the basal rate of uptake per mg protein was highest. This indicates that tissue culture medium content of lipoprotein cholesterol can regulate the uptake of chylomicron remnants in hepatocytes, analogous to the regulation of the LDL receptor in extrahepatic cell.
Please use this url to cite or link to this publication:
author
; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
48
issue
6
pages
4 pages
publisher
Informa Healthcare
external identifiers
  • pmid:3217758
  • scopus:0024097569
ISSN
1502-7686
DOI
10.3109/00365518809085772
language
English
LU publication?
no
id
c7108776-9c28-46ac-9ddf-b56e759466c8
date added to LUP
2019-05-30 16:40:17
date last changed
2021-11-30 04:03:41
@article{c7108776-9c28-46ac-9ddf-b56e759466c8,
  abstract     = {{Rat hepatocyte monolayers were cultured in the presence of 1-10% lipoprotein-deficient foetal calf serum. This increased the uptake and degradation of chylomicron remnant cholesteryl ester significantly. The increase occurred at all cell densities, i.e. also with less dense cultures where the basal rate of uptake per mg protein was highest. This indicates that tissue culture medium content of lipoprotein cholesterol can regulate the uptake of chylomicron remnants in hepatocytes, analogous to the regulation of the LDL receptor in extrahepatic cell.}},
  author       = {{Jensen, Elmo and Florén, Claes-Henrik and Nilsson, Åke}},
  issn         = {{1502-7686}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{6}},
  pages        = {{553--556}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
  title        = {{Lipoprotein deficient serum stimulates the uptake of chylomicron remnants in cultured hepatocytes}},
  url          = {{http://dx.doi.org/10.3109/00365518809085772}},
  doi          = {{10.3109/00365518809085772}},
  volume       = {{48}},
  year         = {{1988}},
}