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Polyphosphoester-stabilized cubosomes encapsulating a Ru(II) complex for the photodynamic treatment of lung adenocarcinoma

Casula, Luca ; Elena Giacomazzo, Gina ; Conti, Luca ; Fornasier, Marco LU orcid ; Manca, Benedetto ; Schlich, Michele ; Sinico, Chiara ; Rheinberger, Timo ; Wurm, Frederik R. and Giorgi, Claudia , et al. (2024) In Journal of Colloid and Interface Science 670. p.234-245
Abstract

The clinical translation of photosensitizers based on ruthenium(II) polypyridyl complexes (RPCs) in photodynamic therapy of cancer faces several challenges. To address these limitations, we conducted an investigation to assess the potential of a cubosome formulation stabilized in water against coalescence utilizing a polyphosphoester analog of Pluronic F127 as a stabilizer and loaded with newly synthesized RPC-based photosensitizer [Ru(dppn)2(bpy-morph)](PF6)2 (bpy-morph = 2,2′-bipyridine-4,4′-diylbis(morpholinomethanone)), PS-Ru. The photophysical characterization of PS-Ru revealed its robust capacity to induce the formation of singlet oxygen (1O2). Furthermore, the physicochemical... (More)

The clinical translation of photosensitizers based on ruthenium(II) polypyridyl complexes (RPCs) in photodynamic therapy of cancer faces several challenges. To address these limitations, we conducted an investigation to assess the potential of a cubosome formulation stabilized in water against coalescence utilizing a polyphosphoester analog of Pluronic F127 as a stabilizer and loaded with newly synthesized RPC-based photosensitizer [Ru(dppn)2(bpy-morph)](PF6)2 (bpy-morph = 2,2′-bipyridine-4,4′-diylbis(morpholinomethanone)), PS-Ru. The photophysical characterization of PS-Ru revealed its robust capacity to induce the formation of singlet oxygen (1O2). Furthermore, the physicochemical analysis of the PS-Ru-loaded cubosomes dispersion demonstrated that the encapsulation of the photosensitizer within the nanoparticles did not disrupt the three-dimensional arrangement of the lipid bilayer. The biological tests showed that PS-Ru-loaded cubosomes exhibited significant phototoxic activity when exposed to the light source, in stark contrast to empty cubosomes and to the same formulation without irradiation. This promising outcome suggests the potential of the formulation in overcoming the drawbacks associated with the clinical use of RPCs in photodynamic therapy for anticancer treatments.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cancer, Drug delivery, Liquid crystalline nanoparticles, Photodynamic therapy, ruthenium(II) polypyridyl complexes
in
Journal of Colloid and Interface Science
volume
670
pages
12 pages
publisher
Elsevier
external identifiers
  • scopus:85193253885
  • pmid:38761576
ISSN
0021-9797
DOI
10.1016/j.jcis.2024.05.088
language
English
LU publication?
yes
id
c7171709-cb07-4681-9177-78d2c3f72c28
date added to LUP
2024-06-13 14:26:52
date last changed
2024-06-14 08:37:39
@article{c7171709-cb07-4681-9177-78d2c3f72c28,
  abstract     = {{<p>The clinical translation of photosensitizers based on ruthenium(II) polypyridyl complexes (RPCs) in photodynamic therapy of cancer faces several challenges. To address these limitations, we conducted an investigation to assess the potential of a cubosome formulation stabilized in water against coalescence utilizing a polyphosphoester analog of Pluronic F127 as a stabilizer and loaded with newly synthesized RPC-based photosensitizer [Ru(dppn)<sub>2</sub>(bpy-morph)](PF<sub>6</sub>)<sub>2</sub> (bpy-morph = 2,2′-bipyridine-4,4′-diylbis(morpholinomethanone)), PS-Ru. The photophysical characterization of PS-Ru revealed its robust capacity to induce the formation of singlet oxygen (<sup>1</sup>O<sub>2</sub>). Furthermore, the physicochemical analysis of the PS-Ru-loaded cubosomes dispersion demonstrated that the encapsulation of the photosensitizer within the nanoparticles did not disrupt the three-dimensional arrangement of the lipid bilayer. The biological tests showed that PS-Ru-loaded cubosomes exhibited significant phototoxic activity when exposed to the light source, in stark contrast to empty cubosomes and to the same formulation without irradiation. This promising outcome suggests the potential of the formulation in overcoming the drawbacks associated with the clinical use of RPCs in photodynamic therapy for anticancer treatments.</p>}},
  author       = {{Casula, Luca and Elena Giacomazzo, Gina and Conti, Luca and Fornasier, Marco and Manca, Benedetto and Schlich, Michele and Sinico, Chiara and Rheinberger, Timo and Wurm, Frederik R. and Giorgi, Claudia and Murgia, Sergio}},
  issn         = {{0021-9797}},
  keywords     = {{Cancer; Drug delivery; Liquid crystalline nanoparticles; Photodynamic therapy; ruthenium(II) polypyridyl complexes}},
  language     = {{eng}},
  month        = {{09}},
  pages        = {{234--245}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Colloid and Interface Science}},
  title        = {{Polyphosphoester-stabilized cubosomes encapsulating a Ru(II) complex for the photodynamic treatment of lung adenocarcinoma}},
  url          = {{http://dx.doi.org/10.1016/j.jcis.2024.05.088}},
  doi          = {{10.1016/j.jcis.2024.05.088}},
  volume       = {{670}},
  year         = {{2024}},
}