Oxidative Stress and Endothelin-1 in Atherosclerotic Renal Artery Stenosis and Effects of Renal Angioplasty
(2011) In Kidney & Blood Pressure Research 34(6). p.396-403- Abstract
- Aims: To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA). Methods: Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout. Results: At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were... (More)
- Aims: To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA). Methods: Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout. Results: At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were significantly elevated in group ARAS versus both healthy controls and group non-RAS. Plasma levels of ET-1 and uric acid were significantly increased in group ARAS versus healthy controls prior to angiography and were significantly reduced compared to baseline 4 weeks after PTRA. PTRA had no significant effects on biomarkers of oxs, inflammation or serum creatinine concentrations. Conclusions: ARAS patients on treatment with antihypertensive agents, acetylsalicylic acid and statins showed elevated inflammatory indices but no increase in oxs. PTRA had no significant effects on inflammatory indices 4 weeks after intervention but reduced plasma ET-1 and uric acid. Copyright (C) 2011 S. Karger AG, Basel (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2252684
- author
- Saeed, A. ; Herlitz, H. ; Nowakowska-Fortuna, E. ; Nilsson, U. ; Alhadad, Alaa LU ; Jensen, G. ; Mattiasson, Ingrid LU ; Lindblad, Bengt LU ; Gottsäter, Anders LU and Guron, G.
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Endothelin-1, Oxidative stress, Renal angioplasty, Renal artery, stenosis, Renovascular hypertension
- in
- Kidney & Blood Pressure Research
- volume
- 34
- issue
- 6
- pages
- 396 - 403
- publisher
- Karger
- external identifiers
-
- wos:000297128400004
- scopus:79958765639
- pmid:21677436
- ISSN
- 1423-0143
- DOI
- 10.1159/000328732
- language
- English
- LU publication?
- yes
- id
- c71afbe7-3867-4d7d-8827-e204bc9a8509 (old id 2252684)
- date added to LUP
- 2016-04-01 14:17:37
- date last changed
- 2022-03-21 23:17:38
@article{c71afbe7-3867-4d7d-8827-e204bc9a8509, abstract = {{Aims: To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA). Methods: Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout. Results: At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were significantly elevated in group ARAS versus both healthy controls and group non-RAS. Plasma levels of ET-1 and uric acid were significantly increased in group ARAS versus healthy controls prior to angiography and were significantly reduced compared to baseline 4 weeks after PTRA. PTRA had no significant effects on biomarkers of oxs, inflammation or serum creatinine concentrations. Conclusions: ARAS patients on treatment with antihypertensive agents, acetylsalicylic acid and statins showed elevated inflammatory indices but no increase in oxs. PTRA had no significant effects on inflammatory indices 4 weeks after intervention but reduced plasma ET-1 and uric acid. Copyright (C) 2011 S. Karger AG, Basel}}, author = {{Saeed, A. and Herlitz, H. and Nowakowska-Fortuna, E. and Nilsson, U. and Alhadad, Alaa and Jensen, G. and Mattiasson, Ingrid and Lindblad, Bengt and Gottsäter, Anders and Guron, G.}}, issn = {{1423-0143}}, keywords = {{Endothelin-1; Oxidative stress; Renal angioplasty; Renal artery; stenosis; Renovascular hypertension}}, language = {{eng}}, number = {{6}}, pages = {{396--403}}, publisher = {{Karger}}, series = {{Kidney & Blood Pressure Research}}, title = {{Oxidative Stress and Endothelin-1 in Atherosclerotic Renal Artery Stenosis and Effects of Renal Angioplasty}}, url = {{http://dx.doi.org/10.1159/000328732}}, doi = {{10.1159/000328732}}, volume = {{34}}, year = {{2011}}, }