Long-chain saturated and monounsaturated fatty acids associate with development of premature infants up to 18 months of age.
(2016) In Prostaglandins, Leukotrienes and Essential Fatty Acids p.43-49- Abstract
- Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted... (More)
- Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted for several confounders. Negative association between oleic acid and long-chain polyunsaturated fatty acids suggests inhibition of delta-9 desaturase, and nervonic acid´s divergent correlation to lignoceric and oleic acids suggests different metabolism in neonatal period. Our results may have implications for the supplementation of premature infants. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8826077
- author
- Strandvik, Birgitta ; Ntoumani, Eleni ; Lundqvist, Cristina LU and Sabel, Karl-Göran
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Prostaglandins, Leukotrienes and Essential Fatty Acids
- pages
- 43 - 49
- publisher
- Elsevier
- external identifiers
-
- pmid:26858144
- wos:000374356900007
- scopus:84962122619
- pmid:26858144
- ISSN
- 0952-3278
- DOI
- 10.1016/j.plefa.2016.01.002
- language
- English
- LU publication?
- yes
- additional info
- First Published Online: 29 January 2016
- id
- c8120d27-9103-4daa-beb0-2f53dec072d0 (old id 8826077)
- date added to LUP
- 2016-04-01 09:49:10
- date last changed
- 2022-04-27 07:50:29
@article{c8120d27-9103-4daa-beb0-2f53dec072d0,
abstract = {{Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted for several confounders. Negative association between oleic acid and long-chain polyunsaturated fatty acids suggests inhibition of delta-9 desaturase, and nervonic acid´s divergent correlation to lignoceric and oleic acids suggests different metabolism in neonatal period. Our results may have implications for the supplementation of premature infants.}},
author = {{Strandvik, Birgitta and Ntoumani, Eleni and Lundqvist, Cristina and Sabel, Karl-Göran}},
issn = {{0952-3278}},
language = {{eng}},
pages = {{43--49}},
publisher = {{Elsevier}},
series = {{Prostaglandins, Leukotrienes and Essential Fatty Acids}},
title = {{Long-chain saturated and monounsaturated fatty acids associate with development of premature infants up to 18 months of age.}},
url = {{http://dx.doi.org/10.1016/j.plefa.2016.01.002}},
doi = {{10.1016/j.plefa.2016.01.002}},
year = {{2016}},
}