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Familial risks in nervous system tumors

Hemminki, Kari LU and Li, Xinjun LU (2003) In Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 12(11 Pt 1). p.1137-1142
Abstract

We used the nationwide Swedish Family-Cancer Database to analyze the risk for nervous system tumors in offspring through parental and sibling probands. Among 0-68-year-old offspring, close to 11000 patients with a nervous system tumor were identified in years 1961 to 2000, among whom 199 had a parent diagnosed with a nervous system tumor. Brain tumors constituted 86% of all tumors, and astrocytoma was the main histological type, representing half of all cases. Standardized incidence ratios (SIRs) for familial risk were only increased for brain tumors of meningioma, astrocytoma, and hemangioblastoma histology. When parents were diagnosed with tumors of the same histology, the SIRs for offspring were 3.06, 2.19, and 165 for meningioma,... (More)

We used the nationwide Swedish Family-Cancer Database to analyze the risk for nervous system tumors in offspring through parental and sibling probands. Among 0-68-year-old offspring, close to 11000 patients with a nervous system tumor were identified in years 1961 to 2000, among whom 199 had a parent diagnosed with a nervous system tumor. Brain tumors constituted 86% of all tumors, and astrocytoma was the main histological type, representing half of all cases. Standardized incidence ratios (SIRs) for familial risk were only increased for brain tumors of meningioma, astrocytoma, and hemangioblastoma histology. When parents were diagnosed with tumors of the same histology, the SIRs for offspring were 3.06, 2.19, and 165 for meningioma, astrocytoma, and hemangioblastoma, respectively. Among siblings, the SIRs were 4.41, 3.20, and 61. Age-specific analysis of familial astrocytoma revealed three distinct components, one < 10 years, the second approximately age 30 years, and the third at age >60 years. The kappa test was used to assess the likelihood of an identical histology in two family members. The occurrence of hemangioblastoma was completely determined among the siblings, and the kappa value was 1.00. Meningiomas were also moderately ordered among the siblings, but astrocytomas were less determined. Many syndromes are known in which nervous system tumors are manifestations, including hemangioblastoma, recognized as part of von Hippel-Lindau disease. Yet, it is likely that many brain astrocytoma, meningioma, and mixed families represent yet unknown heritable conditions.

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published
subject
keywords
Adolescent, Adult, Aged, Astrocytoma/etiology, Brain Neoplasms/etiology, Child, Child, Preschool, Databases, Factual, Epidemiologic Studies, Humans, Infant, Infant, Newborn, Meningioma/etiology, Middle Aged, Nervous System Neoplasms/etiology, Pedigree, Retrospective Studies, Risk Factors, Sweden/epidemiology
in
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
volume
12
issue
11 Pt 1
pages
6 pages
publisher
American Association for Cancer Research
external identifiers
  • scopus:0344198159
ISSN
1055-9965
language
English
LU publication?
no
id
c8285d42-dc9c-4695-b60e-565a5d18cd15
alternative location
http://cebp.aacrjournals.org/content/12/11/1137.long
date added to LUP
2019-01-30 11:46:11
date last changed
2019-02-20 11:45:46
@article{c8285d42-dc9c-4695-b60e-565a5d18cd15,
  abstract     = {<p>We used the nationwide Swedish Family-Cancer Database to analyze the risk for nervous system tumors in offspring through parental and sibling probands. Among 0-68-year-old offspring, close to 11000 patients with a nervous system tumor were identified in years 1961 to 2000, among whom 199 had a parent diagnosed with a nervous system tumor. Brain tumors constituted 86% of all tumors, and astrocytoma was the main histological type, representing half of all cases. Standardized incidence ratios (SIRs) for familial risk were only increased for brain tumors of meningioma, astrocytoma, and hemangioblastoma histology. When parents were diagnosed with tumors of the same histology, the SIRs for offspring were 3.06, 2.19, and 165 for meningioma, astrocytoma, and hemangioblastoma, respectively. Among siblings, the SIRs were 4.41, 3.20, and 61. Age-specific analysis of familial astrocytoma revealed three distinct components, one &lt; 10 years, the second approximately age 30 years, and the third at age &gt;60 years. The kappa test was used to assess the likelihood of an identical histology in two family members. The occurrence of hemangioblastoma was completely determined among the siblings, and the kappa value was 1.00. Meningiomas were also moderately ordered among the siblings, but astrocytomas were less determined. Many syndromes are known in which nervous system tumors are manifestations, including hemangioblastoma, recognized as part of von Hippel-Lindau disease. Yet, it is likely that many brain astrocytoma, meningioma, and mixed families represent yet unknown heritable conditions.</p>},
  author       = {Hemminki, Kari and Li, Xinjun},
  issn         = {1055-9965},
  keyword      = {Adolescent,Adult,Aged,Astrocytoma/etiology,Brain Neoplasms/etiology,Child,Child, Preschool,Databases, Factual,Epidemiologic Studies,Humans,Infant,Infant, Newborn,Meningioma/etiology,Middle Aged,Nervous System Neoplasms/etiology,Pedigree,Retrospective Studies,Risk Factors,Sweden/epidemiology},
  language     = {eng},
  number       = {11 Pt 1},
  pages        = {1137--1142},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  title        = {Familial risks in nervous system tumors},
  volume       = {12},
  year         = {2003},
}