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Multifunctional chitosan cryogel bandages via column-flow synthesis for simultaneous hemostasis and anti-biofilm therapy

Zhang, Qicheng LU ; Zhang, Jian ; Fang, Zhurun ; Hajizadeh, Solmaz LU orcid ; Zhang, Jiarong ; Yang, Qifei ; Ye, Lei LU orcid and Zhang, Ming (2026) In International Journal of Biological Macromolecules 370.
Abstract
Bacterial infection and hemorrhage remain significant clinical challenges for chronic wounds, despite advancements in antimicrobial strategies and materials. Herein, 980 nm-laser-responsive photothermal conjugated polymers (CPs) are combined with chitosan-based cryogels (CP@Gel) to achieve rapid hemostasis and efficient anti-infectious performance. CP nanoparticles (CP NPs) were prepared by nanoprecipitation and immobilized into cryogels via a novel column-flow-through method, resulting in high nanoparticle loading capacity and enhanced photothermal effects. The chitosan-based cryogels demonstrated quick blood absorption and rapid hemostatic abilities. Under near-infrared (NIR) exposure, the photothermal effect of CP@Gel induced bacterial... (More)
Bacterial infection and hemorrhage remain significant clinical challenges for chronic wounds, despite advancements in antimicrobial strategies and materials. Herein, 980 nm-laser-responsive photothermal conjugated polymers (CPs) are combined with chitosan-based cryogels (CP@Gel) to achieve rapid hemostasis and efficient anti-infectious performance. CP nanoparticles (CP NPs) were prepared by nanoprecipitation and immobilized into cryogels via a novel column-flow-through method, resulting in high nanoparticle loading capacity and enhanced photothermal effects. The chitosan-based cryogels demonstrated quick blood absorption and rapid hemostatic abilities. Under near-infrared (NIR) exposure, the photothermal effect of CP@Gel induced bacterial membrane disruption and cytoplasmic leakage, nearly eliminating Methicillin-resistant Staphylococcus aureus (MRSA) within 5 min. Moreover, CP@Gel under NIR laser irradiation effectively destroyed mature MRSA biofilms and affected related biofilm-formation genes. Meanwhile, CP@Gel/NIR promoted MRSA-induced wound healing by controlling inflammatory responses, angiogenesis, collagen deposition, and affecting the expression of genes associated with inflammation and immune response. This work provides a promising approach for chronic wound healing by addressing both hemorrhage and MRSA contamination. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Biological Macromolecules
volume
370
article number
152852
publisher
Elsevier
external identifiers
  • pmid:42229662
  • scopus:105041133518
ISSN
1879-0003
DOI
10.1016/j.ijbiomac.2026.152852
language
English
LU publication?
yes
id
c8292651-b1d1-44d5-9e6c-7d16c7076c8d
date added to LUP
2026-06-29 11:47:20
date last changed
2026-06-30 04:00:54
@article{c8292651-b1d1-44d5-9e6c-7d16c7076c8d,
  abstract     = {{Bacterial infection and hemorrhage remain significant clinical challenges for chronic wounds, despite advancements in antimicrobial strategies and materials. Herein, 980 nm-laser-responsive photothermal conjugated polymers (CPs) are combined with chitosan-based cryogels (CP@Gel) to achieve rapid hemostasis and efficient anti-infectious performance. CP nanoparticles (CP NPs) were prepared by nanoprecipitation and immobilized into cryogels via a novel column-flow-through method, resulting in high nanoparticle loading capacity and enhanced photothermal effects. The chitosan-based cryogels demonstrated quick blood absorption and rapid hemostatic abilities. Under near-infrared (NIR) exposure, the photothermal effect of CP@Gel induced bacterial membrane disruption and cytoplasmic leakage, nearly eliminating Methicillin-resistant Staphylococcus aureus (MRSA) within 5 min. Moreover, CP@Gel under NIR laser irradiation effectively destroyed mature MRSA biofilms and affected related biofilm-formation genes. Meanwhile, CP@Gel/NIR promoted MRSA-induced wound healing by controlling inflammatory responses, angiogenesis, collagen deposition, and affecting the expression of genes associated with inflammation and immune response. This work provides a promising approach for chronic wound healing by addressing both hemorrhage and MRSA contamination.}},
  author       = {{Zhang, Qicheng and Zhang, Jian and Fang, Zhurun and Hajizadeh, Solmaz and Zhang, Jiarong and Yang, Qifei and Ye, Lei and Zhang, Ming}},
  issn         = {{1879-0003}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Biological Macromolecules}},
  title        = {{Multifunctional chitosan cryogel bandages via column-flow synthesis for simultaneous hemostasis and anti-biofilm therapy}},
  url          = {{http://dx.doi.org/10.1016/j.ijbiomac.2026.152852}},
  doi          = {{10.1016/j.ijbiomac.2026.152852}},
  volume       = {{370}},
  year         = {{2026}},
}