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The interaction of erythromycin with theophylline

Paulsen, Otto; Höglund, P LU ; Nilsson, L G and Bengtsson, H I (1987) In European Journal of Clinical Pharmacology 32(5). p.8-493
Abstract

We have studied the interaction of erythromycin with theophylline. We gave ten healthy volunteers theophylline as an intravenous loading dose (5 mg X kg-1) over 1 h, followed by a maintenance infusion (0.5 mg X kg-1 X h-1) for 5 h. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined during the infusion periods. The concentrations of erythromycin were measured for 8 h, after one week of treatment, and also after the last erythromycin dose, simultaneously with the second theophylline infusion. Concentrations within the therapeutic range were obtained with both drugs. A significant increase in both AUC and mean plasma concentrations... (More)

We have studied the interaction of erythromycin with theophylline. We gave ten healthy volunteers theophylline as an intravenous loading dose (5 mg X kg-1) over 1 h, followed by a maintenance infusion (0.5 mg X kg-1 X h-1) for 5 h. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined during the infusion periods. The concentrations of erythromycin were measured for 8 h, after one week of treatment, and also after the last erythromycin dose, simultaneously with the second theophylline infusion. Concentrations within the therapeutic range were obtained with both drugs. A significant increase in both AUC and mean plasma concentrations of theophylline was seen during erythromycin treatment. The plasma clearance of theophylline was reduced in 9 of the 10 subjects. Renal clearance increased correspondingly, but the change was not statistically significant. Serum concentrations of erythromycin fell significantly, by more than 30%, with concurrent theophylline medication. We conclude that an interaction between theophylline and erythromycin, affecting both drugs, can be shown with concentrations of the drugs within the therapeutic range.

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published
subject
keywords
Adult, Drug Interactions, Erythromycin, Female, Humans, Infusions, Intravenous, Injections, Intravenous, Kidney, Kinetics, Male, Metabolic Clearance Rate, Middle Aged, Theophylline, Journal Article
in
European Journal of Clinical Pharmacology
volume
32
issue
5
pages
6 pages
publisher
Springer
external identifiers
  • scopus:0023194655
ISSN
0031-6970
language
English
LU publication?
yes
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c850c48d-1b68-4595-90cb-567183ef829d
date added to LUP
2017-09-14 23:46:23
date last changed
2017-09-18 16:24:57
@article{c850c48d-1b68-4595-90cb-567183ef829d,
  abstract     = {<p>We have studied the interaction of erythromycin with theophylline. We gave ten healthy volunteers theophylline as an intravenous loading dose (5 mg X kg-1) over 1 h, followed by a maintenance infusion (0.5 mg X kg-1 X h-1) for 5 h. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined during the infusion periods. The concentrations of erythromycin were measured for 8 h, after one week of treatment, and also after the last erythromycin dose, simultaneously with the second theophylline infusion. Concentrations within the therapeutic range were obtained with both drugs. A significant increase in both AUC and mean plasma concentrations of theophylline was seen during erythromycin treatment. The plasma clearance of theophylline was reduced in 9 of the 10 subjects. Renal clearance increased correspondingly, but the change was not statistically significant. Serum concentrations of erythromycin fell significantly, by more than 30%, with concurrent theophylline medication. We conclude that an interaction between theophylline and erythromycin, affecting both drugs, can be shown with concentrations of the drugs within the therapeutic range.</p>},
  author       = {Paulsen, Otto and Höglund, P and Nilsson, L G and Bengtsson, H I},
  issn         = {0031-6970},
  keyword      = {Adult,Drug Interactions,Erythromycin,Female,Humans,Infusions, Intravenous,Injections, Intravenous,Kidney,Kinetics,Male,Metabolic Clearance Rate,Middle Aged,Theophylline,Journal Article},
  language     = {eng},
  number       = {5},
  pages        = {8--493},
  publisher    = {Springer},
  series       = {European Journal of Clinical Pharmacology},
  title        = {The interaction of erythromycin with theophylline},
  volume       = {32},
  year         = {1987},
}