Mitochondrial DNA Copy Number: Linking Diabetes and Cancer
Memon, Ashfaque A LU
; Vats, Sakshi
LU
; Sundquist, Jan
LU
; Li, Yanni
LU
and Sundquist, Kristina
LU
(2022)
In Antioxidants and Redox Signaling
37(16-18).
p.1168-1190
- Abstract
- Recent Advances: Various studies have suggested that mitochondrial DNA copy number (mtDNA-CN), a surrogate biomarker of mitochondrial dysfunction, is an easily quantifiable biomarker for chronic diseases, including diabetes and cancer. However, current knowledge is limited, and the results are controversial. This has been attributed mainly to methodology and study design.
Critical Issues: The incidence of diabetes and cancer has increased significantly in recent years. Moreover, type 2 diabetes (T2D) has been shown to be a risk factor for cancer. mtDNA-CN has been associated with both T2D and cancer. However, it is not known whether mtDNA-CN plays any role in the association between T2D and cancer.
Significance: In this... (More) - Recent Advances: Various studies have suggested that mitochondrial DNA copy number (mtDNA-CN), a surrogate biomarker of mitochondrial dysfunction, is an easily quantifiable biomarker for chronic diseases, including diabetes and cancer. However, current knowledge is limited, and the results are controversial. This has been attributed mainly to methodology and study design.
Critical Issues: The incidence of diabetes and cancer has increased significantly in recent years. Moreover, type 2 diabetes (T2D) has been shown to be a risk factor for cancer. mtDNA-CN has been associated with both T2D and cancer. However, it is not known whether mtDNA-CN plays any role in the association between T2D and cancer.
Significance: In this review, we have discussed mtDNA-CN in diabetes and cancer, and reviewed the literature and methodology used in published studies so far. Based on the literature review, we have speculated how mtDNA-CN may act as a link between diabetes and cancer. Furthermore, we have provided some recommendations for reliable translation of mtDNA-CN as a biomarker.
Future Directions: Further research is required to elucidate the role of mtDNA-CN in the association between T2D and cancer. If established, early lifestyle interventions, such as physical activity and diet control that improve mitochondrial function, may help preventing cancer in patients with T2D. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c8ab9cd6-1c88-4db6-89fd-34a2cc6918d2
- author
- Memon, Ashfaque A
LU
; Vats, Sakshi
LU
; Sundquist, Jan
LU
; Li, Yanni
LU
and Sundquist, Kristina
LU
- organization
- publishing date
- 2022-12-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Mitochondria, Mitochondrial copy number, mitochondrial dysfunction, biomarker, diabetes, cancer
- in
- Antioxidants and Redox Signaling
- volume
- 37
- issue
- 16-18
- pages
- 23 pages
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- pmid:36169625
- scopus:85143645221
- ISSN
- 1557-7716
- DOI
- 10.1089/ars.2022.0100
- language
- English
- LU publication?
- yes
- id
- c8ab9cd6-1c88-4db6-89fd-34a2cc6918d2
- date added to LUP
- 2022-09-29 13:10:09
- date last changed
- 2023-01-22 04:13:40
@article{c8ab9cd6-1c88-4db6-89fd-34a2cc6918d2,
abstract = {{Recent Advances: Various studies have suggested that mitochondrial DNA copy number (mtDNA-CN), a surrogate biomarker of mitochondrial dysfunction, is an easily quantifiable biomarker for chronic diseases, including diabetes and cancer. However, current knowledge is limited, and the results are controversial. This has been attributed mainly to methodology and study design.<br/><br/>Critical Issues: The incidence of diabetes and cancer has increased significantly in recent years. Moreover, type 2 diabetes (T2D) has been shown to be a risk factor for cancer. mtDNA-CN has been associated with both T2D and cancer. However, it is not known whether mtDNA-CN plays any role in the association between T2D and cancer.<br/><br/>Significance: In this review, we have discussed mtDNA-CN in diabetes and cancer, and reviewed the literature and methodology used in published studies so far. Based on the literature review, we have speculated how mtDNA-CN may act as a link between diabetes and cancer. Furthermore, we have provided some recommendations for reliable translation of mtDNA-CN as a biomarker.<br/><br/>Future Directions: Further research is required to elucidate the role of mtDNA-CN in the association between T2D and cancer. If established, early lifestyle interventions, such as physical activity and diet control that improve mitochondrial function, may help preventing cancer in patients with T2D.}},
author = {{Memon, Ashfaque A and Vats, Sakshi and Sundquist, Jan and Li, Yanni and Sundquist, Kristina}},
issn = {{1557-7716}},
keywords = {{Mitochondria; Mitochondrial copy number; mitochondrial dysfunction; biomarker; diabetes; cancer}},
language = {{eng}},
month = {{12}},
number = {{16-18}},
pages = {{1168--1190}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Antioxidants and Redox Signaling}},
title = {{Mitochondrial DNA Copy Number: Linking Diabetes and Cancer}},
url = {{http://dx.doi.org/10.1089/ars.2022.0100}},
doi = {{10.1089/ars.2022.0100}},
volume = {{37}},
year = {{2022}},
}