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Lysosomal cell death at a glance

Aits, Sonja LU and Jäättelä, Marja (2013) In Journal of Cell Science 126(9). p.1905-1912
Abstract

Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases that can degrade most cellular macromolecules. Lysosomal membrane permeabilization and the consequent leakage of the lysosomal content into the cytosol leads to so-called "lysosomal cell death". This form of cell death is mainly carried out by the lysosomal cathepsin proteases and can have necrotic, apoptotic or apoptosis-like features depending on the extent of the leakage and the cellular context. This article summarizes our current knowledge on lysosomal cell death with an emphasis on the upstream mechanisms that lead to lysosomal membrane permeabilization.

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author
publishing date
type
Contribution to journal
publication status
published
in
Journal of Cell Science
volume
126
issue
9
pages
1905 - 1912
publisher
The Company of Biologists Ltd
external identifiers
  • scopus:84878643872
ISSN
0021-9533
DOI
10.1242/jcs.091181
language
English
LU publication?
no
id
c8b10c3c-4fbb-40dd-8390-ec6121cd8c1f
date added to LUP
2018-03-05 15:26:27
date last changed
2018-11-11 05:00:38
@article{c8b10c3c-4fbb-40dd-8390-ec6121cd8c1f,
  abstract     = {<p>Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases that can degrade most cellular macromolecules. Lysosomal membrane permeabilization and the consequent leakage of the lysosomal content into the cytosol leads to so-called "lysosomal cell death". This form of cell death is mainly carried out by the lysosomal cathepsin proteases and can have necrotic, apoptotic or apoptosis-like features depending on the extent of the leakage and the cellular context. This article summarizes our current knowledge on lysosomal cell death with an emphasis on the upstream mechanisms that lead to lysosomal membrane permeabilization.</p>},
  author       = {Aits, Sonja and Jäättelä, Marja},
  issn         = {0021-9533},
  language     = {eng},
  month        = {05},
  number       = {9},
  pages        = {1905--1912},
  publisher    = {The Company of Biologists Ltd},
  series       = {Journal of Cell Science},
  title        = {Lysosomal cell death at a glance},
  url          = {http://dx.doi.org/10.1242/jcs.091181},
  volume       = {126},
  year         = {2013},
}