Lysosomal cell death at a glance
Aits, Sonja LU
and Jäättelä, Marja
(2013)
In Journal of Cell Science
126(9).
p.1905-1912
- Abstract
Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases that can degrade most cellular macromolecules. Lysosomal membrane permeabilization and the consequent leakage of the lysosomal content into the cytosol leads to so-called "lysosomal cell death". This form of cell death is mainly carried out by the lysosomal cathepsin proteases and can have necrotic, apoptotic or apoptosis-like features depending on the extent of the leakage and the cellular context. This article summarizes our current knowledge on lysosomal cell death with an emphasis on the upstream mechanisms that lead to lysosomal membrane permeabilization.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c8b10c3c-4fbb-40dd-8390-ec6121cd8c1f
- author
- Aits, Sonja
LU
and Jäättelä, Marja
- publishing date
- 2013-05-01
- type
- Contribution to journal
- publication status
- published
- in
- Journal of Cell Science
- volume
- 126
- issue
- 9
- pages
- 1905 - 1912
- publisher
- The Company of Biologists Ltd
- external identifiers
-
- scopus:84878643872
- pmid:23720375
- ISSN
- 0021-9533
- DOI
- 10.1242/jcs.091181
- language
- English
- LU publication?
- no
- id
- c8b10c3c-4fbb-40dd-8390-ec6121cd8c1f
- date added to LUP
- 2018-03-05 15:26:27
- date last changed
- 2024-06-11 11:39:14
@article{c8b10c3c-4fbb-40dd-8390-ec6121cd8c1f,
abstract = {{<p>Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases that can degrade most cellular macromolecules. Lysosomal membrane permeabilization and the consequent leakage of the lysosomal content into the cytosol leads to so-called "lysosomal cell death". This form of cell death is mainly carried out by the lysosomal cathepsin proteases and can have necrotic, apoptotic or apoptosis-like features depending on the extent of the leakage and the cellular context. This article summarizes our current knowledge on lysosomal cell death with an emphasis on the upstream mechanisms that lead to lysosomal membrane permeabilization.</p>}},
author = {{Aits, Sonja and Jäättelä, Marja}},
issn = {{0021-9533}},
language = {{eng}},
month = {{05}},
number = {{9}},
pages = {{1905--1912}},
publisher = {{The Company of Biologists Ltd}},
series = {{Journal of Cell Science}},
title = {{Lysosomal cell death at a glance}},
url = {{http://dx.doi.org/10.1242/jcs.091181}},
doi = {{10.1242/jcs.091181}},
volume = {{126}},
year = {{2013}},
}