Low levels of soluble neuropilin-1 were associated with depression in adults with newly diagnosed type 2 diabetes
(2025) In Diabetes, Obesity and Metabolism 27(6). p.3299-3308- Abstract
Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepressants, BMI, haemoglobin A1c, C-peptide and pre-existing cardiovascular disease. Multiple regression analyses were performed with depression and low sNRP-1 as dependent variables. Results: The study comprised 837 participants (18–94 years, younger patients <60 years 38%). Depressed patients (n = 119) compared to non-depressed (n = 718) had... (More)
Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepressants, BMI, haemoglobin A1c, C-peptide and pre-existing cardiovascular disease. Multiple regression analyses were performed with depression and low sNRP-1 as dependent variables. Results: The study comprised 837 participants (18–94 years, younger patients <60 years 38%). Depressed patients (n = 119) compared to non-depressed (n = 718) had a higher prevalence of anxiety (64% vs. 14%), antidepressants (36% vs. 14%), low sNRP-1 (45% vs. 22%) (all p < 0.001); physical inactivity (42% vs. 29%, p = 0.006); smoking (20% vs. 12%, p = 0.018); and higher BMI (p = 0.002). Independently associated with depression (n = 736) were anxiety (adjusted odds ratio (AOR) 11.7, p < 0.001), low sNRP-1 (AOR 3.3, p < 0.001), BMI (per kg/m2) (AOR 1.1, p = 0.016) and physical inactivity (AOR 1.8, p = 0.018). In younger patients (n = 288), independently associated with low sNRP-1 were depression (AOR 3.3, p < 0.001), myocardial infarction (AOR 3.8, p = 0.039) and younger age (per year) (AOR 0.97, p = 0.043). In older patients (n = 521), independently associated with low sNRP-1 were depression (AOR 3.1, p < 0.001), and younger age (0.97, p = 0.030). Conclusions: Low sNRP-1 (<226 ng/mL) was associated with depression in all patients with newly diagnosed T2D. In younger patients (<60 years), depression, pre-existing myocardial infarction and younger age were associated with low sNRP-1. In older patients, only depression and younger age were associated with low sNRP-1.
(Less)
- author
- Melin, E. O.
LU
; Thunander, M.
LU
; Wanby, P.
; Holmberg, S.
LU
; Thulesius, H. O.
LU
; Landin-Olsson, M. LU and Hillman, M. LU
- organization
-
- Diabetes lab (research group)
- Division of Occupational and Environmental Medicine, Lund University
- Environmental Epidemiology (research group)
- Family Medicine and Community Medicine (research group)
- Medicine/Emergency Medicine, Lund
- EpiHealth: Epidemiology for Health
- The Faculty of Medicine Centre for Teaching and Learning
- EXODIAB: Excellence of Diabetes Research in Sweden
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- depression, diabetes mellitus type 2, inflammation, soluble neuropilin-1
- in
- Diabetes, Obesity and Metabolism
- volume
- 27
- issue
- 6
- pages
- 10 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:105001712960
- pmid:40150914
- ISSN
- 1462-8902
- DOI
- 10.1111/dom.16347
- language
- English
- LU publication?
- yes
- id
- c91ce832-7c40-4086-be14-b3cf7cb1144d
- date added to LUP
- 2025-09-04 14:24:51
- date last changed
- 2025-10-02 17:17:24
@article{c91ce832-7c40-4086-be14-b3cf7cb1144d, abstract = {{<p>Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepressants, BMI, haemoglobin A1c, C-peptide and pre-existing cardiovascular disease. Multiple regression analyses were performed with depression and low sNRP-1 as dependent variables. Results: The study comprised 837 participants (18–94 years, younger patients <60 years 38%). Depressed patients (n = 119) compared to non-depressed (n = 718) had a higher prevalence of anxiety (64% vs. 14%), antidepressants (36% vs. 14%), low sNRP-1 (45% vs. 22%) (all p < 0.001); physical inactivity (42% vs. 29%, p = 0.006); smoking (20% vs. 12%, p = 0.018); and higher BMI (p = 0.002). Independently associated with depression (n = 736) were anxiety (adjusted odds ratio (AOR) 11.7, p < 0.001), low sNRP-1 (AOR 3.3, p < 0.001), BMI (per kg/m<sup>2</sup>) (AOR 1.1, p = 0.016) and physical inactivity (AOR 1.8, p = 0.018). In younger patients (n = 288), independently associated with low sNRP-1 were depression (AOR 3.3, p < 0.001), myocardial infarction (AOR 3.8, p = 0.039) and younger age (per year) (AOR 0.97, p = 0.043). In older patients (n = 521), independently associated with low sNRP-1 were depression (AOR 3.1, p < 0.001), and younger age (0.97, p = 0.030). Conclusions: Low sNRP-1 (<226 ng/mL) was associated with depression in all patients with newly diagnosed T2D. In younger patients (<60 years), depression, pre-existing myocardial infarction and younger age were associated with low sNRP-1. In older patients, only depression and younger age were associated with low sNRP-1.</p>}}, author = {{Melin, E. O. and Thunander, M. and Wanby, P. and Holmberg, S. and Thulesius, H. O. and Landin-Olsson, M. and Hillman, M.}}, issn = {{1462-8902}}, keywords = {{depression; diabetes mellitus type 2; inflammation; soluble neuropilin-1}}, language = {{eng}}, number = {{6}}, pages = {{3299--3308}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Diabetes, Obesity and Metabolism}}, title = {{Low levels of soluble neuropilin-1 were associated with depression in adults with newly diagnosed type 2 diabetes}}, url = {{http://dx.doi.org/10.1111/dom.16347}}, doi = {{10.1111/dom.16347}}, volume = {{27}}, year = {{2025}}, }