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Low levels of soluble neuropilin-1 were associated with depression in adults with newly diagnosed type 2 diabetes

Melin, E. O. LU ; Thunander, M. LU ; Wanby, P. ; Holmberg, S. LU ; Thulesius, H. O. LU orcid ; Landin-Olsson, M. LU and Hillman, M. LU orcid (2025) In Diabetes, Obesity and Metabolism 27(6). p.3299-3308
Abstract

Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepressants, BMI, haemoglobin A1c, C-peptide and pre-existing cardiovascular disease. Multiple regression analyses were performed with depression and low sNRP-1 as dependent variables. Results: The study comprised 837 participants (18–94 years, younger patients <60 years 38%). Depressed patients (n = 119) compared to non-depressed (n = 718) had... (More)

Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepressants, BMI, haemoglobin A1c, C-peptide and pre-existing cardiovascular disease. Multiple regression analyses were performed with depression and low sNRP-1 as dependent variables. Results: The study comprised 837 participants (18–94 years, younger patients <60 years 38%). Depressed patients (n = 119) compared to non-depressed (n = 718) had a higher prevalence of anxiety (64% vs. 14%), antidepressants (36% vs. 14%), low sNRP-1 (45% vs. 22%) (all p < 0.001); physical inactivity (42% vs. 29%, p = 0.006); smoking (20% vs. 12%, p = 0.018); and higher BMI (p = 0.002). Independently associated with depression (n = 736) were anxiety (adjusted odds ratio (AOR) 11.7, p < 0.001), low sNRP-1 (AOR 3.3, p < 0.001), BMI (per kg/m2) (AOR 1.1, p = 0.016) and physical inactivity (AOR 1.8, p = 0.018). In younger patients (n = 288), independently associated with low sNRP-1 were depression (AOR 3.3, p < 0.001), myocardial infarction (AOR 3.8, p = 0.039) and younger age (per year) (AOR 0.97, p = 0.043). In older patients (n = 521), independently associated with low sNRP-1 were depression (AOR 3.1, p < 0.001), and younger age (0.97, p = 0.030). Conclusions: Low sNRP-1 (<226 ng/mL) was associated with depression in all patients with newly diagnosed T2D. In younger patients (<60 years), depression, pre-existing myocardial infarction and younger age were associated with low sNRP-1. In older patients, only depression and younger age were associated with low sNRP-1.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
depression, diabetes mellitus type 2, inflammation, soluble neuropilin-1
in
Diabetes, Obesity and Metabolism
volume
27
issue
6
pages
10 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:105001712960
  • pmid:40150914
ISSN
1462-8902
DOI
10.1111/dom.16347
language
English
LU publication?
yes
id
c91ce832-7c40-4086-be14-b3cf7cb1144d
date added to LUP
2025-09-04 14:24:51
date last changed
2025-10-16 19:10:56
@article{c91ce832-7c40-4086-be14-b3cf7cb1144d,
  abstract     = {{<p>Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as &lt;226 ng/mL), psychometrically assessed depression and anxiety, antidepressants, BMI, haemoglobin A1c, C-peptide and pre-existing cardiovascular disease. Multiple regression analyses were performed with depression and low sNRP-1 as dependent variables. Results: The study comprised 837 participants (18–94 years, younger patients &lt;60 years 38%). Depressed patients (n = 119) compared to non-depressed (n = 718) had a higher prevalence of anxiety (64% vs. 14%), antidepressants (36% vs. 14%), low sNRP-1 (45% vs. 22%) (all p &lt; 0.001); physical inactivity (42% vs. 29%, p = 0.006); smoking (20% vs. 12%, p = 0.018); and higher BMI (p = 0.002). Independently associated with depression (n = 736) were anxiety (adjusted odds ratio (AOR) 11.7, p &lt; 0.001), low sNRP-1 (AOR 3.3, p &lt; 0.001), BMI (per kg/m<sup>2</sup>) (AOR 1.1, p = 0.016) and physical inactivity (AOR 1.8, p = 0.018). In younger patients (n = 288), independently associated with low sNRP-1 were depression (AOR 3.3, p &lt; 0.001), myocardial infarction (AOR 3.8, p = 0.039) and younger age (per year) (AOR 0.97, p = 0.043). In older patients (n = 521), independently associated with low sNRP-1 were depression (AOR 3.1, p &lt; 0.001), and younger age (0.97, p = 0.030). Conclusions: Low sNRP-1 (&lt;226 ng/mL) was associated with depression in all patients with newly diagnosed T2D. In younger patients (&lt;60 years), depression, pre-existing myocardial infarction and younger age were associated with low sNRP-1. In older patients, only depression and younger age were associated with low sNRP-1.</p>}},
  author       = {{Melin, E. O. and Thunander, M. and Wanby, P. and Holmberg, S. and Thulesius, H. O. and Landin-Olsson, M. and Hillman, M.}},
  issn         = {{1462-8902}},
  keywords     = {{depression; diabetes mellitus type 2; inflammation; soluble neuropilin-1}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{3299--3308}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Diabetes, Obesity and Metabolism}},
  title        = {{Low levels of soluble neuropilin-1 were associated with depression in adults with newly diagnosed type 2 diabetes}},
  url          = {{http://dx.doi.org/10.1111/dom.16347}},
  doi          = {{10.1111/dom.16347}},
  volume       = {{27}},
  year         = {{2025}},
}