Carrier medium exchange through ultrasonic particle switching in microfluidic channels
(2005) In Analytical Chemistry 77(5). p.1216-1221- Abstract
- This paper describes a method, utilizing acoustic force manipulation of suspended particles, in which particles in a laminar flow microchannel are continuously translated from one medium to another with virtually no mixing of the two media. During the study, 5-mum polyamide spheres suspended in distilled water, spiked (contaminated) with Evans blue, were switched over to clean distilled water. More than 95% of the polyamide spheres could be collected in the clean medium while removing up to 95% of the contaminant. Preliminary experiments to use this method to wash blood were performed. Red blood cells were switched from blood, spiked with Evans blue, to clean blood plasma. At least 95% of the red blood cells (bovine blood) could be... (More)
- This paper describes a method, utilizing acoustic force manipulation of suspended particles, in which particles in a laminar flow microchannel are continuously translated from one medium to another with virtually no mixing of the two media. During the study, 5-mum polyamide spheres suspended in distilled water, spiked (contaminated) with Evans blue, were switched over to clean distilled water. More than 95% of the polyamide spheres could be collected in the clean medium while removing up to 95% of the contaminant. Preliminary experiments to use this method to wash blood were performed. Red blood cells were switched from blood, spiked with Evans blue, to clean blood plasma. At least 95% of the red blood cells (bovine blood) could be collected in clean blood plasma while up to 98% of the contaminant was removed. The obtained results indicate that the presented method can be used as a generic method for particle washing and, more specifically, be applied for both intraoperative and postoperative blood washing. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/250996
- author
- Petersson, Filip LU ; Lenshof, Andreas LU ; Bjursten, Henrik LU and Laurell, Thomas LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Analytical Chemistry
- volume
- 77
- issue
- 5
- pages
- 1216 - 1221
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000227409800010
- scopus:14744269752
- ISSN
- 1520-6882
- DOI
- 10.1021/ac048394q
- language
- English
- LU publication?
- yes
- id
- c95240fc-a82f-4823-b06f-3c18cfba092f (old id 250996)
- date added to LUP
- 2016-04-01 12:28:10
- date last changed
- 2022-04-13 19:28:03
@article{c95240fc-a82f-4823-b06f-3c18cfba092f,
abstract = {{This paper describes a method, utilizing acoustic force manipulation of suspended particles, in which particles in a laminar flow microchannel are continuously translated from one medium to another with virtually no mixing of the two media. During the study, 5-mum polyamide spheres suspended in distilled water, spiked (contaminated) with Evans blue, were switched over to clean distilled water. More than 95% of the polyamide spheres could be collected in the clean medium while removing up to 95% of the contaminant. Preliminary experiments to use this method to wash blood were performed. Red blood cells were switched from blood, spiked with Evans blue, to clean blood plasma. At least 95% of the red blood cells (bovine blood) could be collected in clean blood plasma while up to 98% of the contaminant was removed. The obtained results indicate that the presented method can be used as a generic method for particle washing and, more specifically, be applied for both intraoperative and postoperative blood washing.}},
author = {{Petersson, Filip and Lenshof, Andreas and Bjursten, Henrik and Laurell, Thomas}},
issn = {{1520-6882}},
language = {{eng}},
number = {{5}},
pages = {{1216--1221}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Analytical Chemistry}},
title = {{Carrier medium exchange through ultrasonic particle switching in microfluidic channels}},
url = {{http://dx.doi.org/10.1021/ac048394q}},
doi = {{10.1021/ac048394q}},
volume = {{77}},
year = {{2005}},
}