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Age-specific familial risks of anxiety. A nation-wide epidemiological study from Sweden

Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2008) In European Archives of Psychiatry and Clinical Neuroscience 258(7). p.5-441
Abstract

OBJECTIVE: Familial risks of anxiety have been assessed in small case-control studies, usually based on reported, but not medically verified, anxiety in family members; thus the degree of familial clustering of these diseases remains to be established.

METHODS: The Multigeneration Register, in which all men (sons) and women (daughters) born in Sweden from 1932 onward are registered together with their parents, was linked to hospital admission data. Standardized incidence ratios (SIRs) were calculated as the ratio of the observed to the expected number of cases of men and women with mothers and/or fathers affected by anxiety, compared with men and women whose mothers and/or fathers were not affected by anxiety.

RESULTS: A... (More)

OBJECTIVE: Familial risks of anxiety have been assessed in small case-control studies, usually based on reported, but not medically verified, anxiety in family members; thus the degree of familial clustering of these diseases remains to be established.

METHODS: The Multigeneration Register, in which all men (sons) and women (daughters) born in Sweden from 1932 onward are registered together with their parents, was linked to hospital admission data. Standardized incidence ratios (SIRs) were calculated as the ratio of the observed to the expected number of cases of men and women with mothers and/or fathers affected by anxiety, compared with men and women whose mothers and/or fathers were not affected by anxiety.

RESULTS: A total of 55,642 and 57,196 cases of anxiety were recorded in offspring and parents, respectively. The overall significant SIRs among men and women with a mother, father or both parents hospitalized for anxiety varied between 1.90 and 5.10. Maternal transmission of anxiety was slightly higher than paternal and the highest SIRs were found in the youngest age groups and among those with both parents affected by anxiety. The degree of parental transmission of anxiety was similar for both men and women.

CONCLUSIONS: This study has provided the first data on age-specific familial clustering of anxiety, based on medically confirmed records. The risks were so high that hereditary factors were considered to be likely to contribute, possibly modified by environmental factors. Age-specific risks tables would be helpful for clinical counseling.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adolescent, Adult, Age Factors, Age of Onset, Aged, Aged, 80 and over, Anxiety/diagnosis, Child, Child, Preschool, Family Health, Female, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Risk Factors, Sex Factors, Sweden/epidemiology, Young Adult
in
European Archives of Psychiatry and Clinical Neuroscience
volume
258
issue
7
pages
5 pages
publisher
Springer
external identifiers
  • pmid:18574614
  • scopus:54949129092
ISSN
0940-1334
DOI
10.1007/s00406-008-0817-8
language
English
LU publication?
no
id
c96f3df9-5717-4423-b4df-b4d66edb6c60
date added to LUP
2019-01-30 10:56:23
date last changed
2019-02-20 11:45:35
@article{c96f3df9-5717-4423-b4df-b4d66edb6c60,
  abstract     = {<p>OBJECTIVE: Familial risks of anxiety have been assessed in small case-control studies, usually based on reported, but not medically verified, anxiety in family members; thus the degree of familial clustering of these diseases remains to be established.</p><p>METHODS: The Multigeneration Register, in which all men (sons) and women (daughters) born in Sweden from 1932 onward are registered together with their parents, was linked to hospital admission data. Standardized incidence ratios (SIRs) were calculated as the ratio of the observed to the expected number of cases of men and women with mothers and/or fathers affected by anxiety, compared with men and women whose mothers and/or fathers were not affected by anxiety.</p><p>RESULTS: A total of 55,642 and 57,196 cases of anxiety were recorded in offspring and parents, respectively. The overall significant SIRs among men and women with a mother, father or both parents hospitalized for anxiety varied between 1.90 and 5.10. Maternal transmission of anxiety was slightly higher than paternal and the highest SIRs were found in the youngest age groups and among those with both parents affected by anxiety. The degree of parental transmission of anxiety was similar for both men and women.</p><p>CONCLUSIONS: This study has provided the first data on age-specific familial clustering of anxiety, based on medically confirmed records. The risks were so high that hereditary factors were considered to be likely to contribute, possibly modified by environmental factors. Age-specific risks tables would be helpful for clinical counseling.</p>},
  author       = {Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
  issn         = {0940-1334},
  language     = {eng},
  number       = {7},
  pages        = {5--441},
  publisher    = {Springer},
  series       = {European Archives of Psychiatry and Clinical Neuroscience},
  title        = {Age-specific familial risks of anxiety. A nation-wide epidemiological study from Sweden},
  url          = {http://dx.doi.org/10.1007/s00406-008-0817-8},
  doi          = {10.1007/s00406-008-0817-8},
  volume       = {258},
  year         = {2008},
}