Increased carotid plaque burden in men with the fibrillin-1 2/3 genotype
De Basso, Rachel ; Hedblad, Bo LU ; Carlson, Joyce LU ; Persson, Margaretha LU
; Östling, Gerd
LU
and Lanne, Toste
(2014)
In Clinical and Experimental Pharmacology and Physiology
41(9).
p.637-642
- Abstract
- Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The FBN1 genotype was characterized in 5765 subjects (2424 men, 3341 women; age 45-69years) recruited from the Malmo Diet and Cancer Study Cardiovascular Cohort, Sweden. Plaque occurrence and intima-media thickness (IMT) of the carotid artery were assessed by ultrasound. The incidence of first cardiovascular events (myocardial infarction and stroke)... (More)
- Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The FBN1 genotype was characterized in 5765 subjects (2424 men, 3341 women; age 45-69years) recruited from the Malmo Diet and Cancer Study Cardiovascular Cohort, Sweden. Plaque occurrence and intima-media thickness (IMT) of the carotid artery were assessed by ultrasound. The incidence of first cardiovascular events (myocardial infarction and stroke) and cause-specific mortality were monitored over a mean follow-up period of 13.2years. The most common FBN1 genotypes were 2/2, 2/3 and 2/4, which accounted for 92.2% (n=5317) of subjects. There were no differences between the three genotypes regarding age, blood pressure, glucose, lipids, smoking habits, common carotid artery diameter and intima-media thickness in men and women. The presence of plaque in the carotid artery was higher in men with the 2/3 genotype compared with the 2/2 and 2/4 genotypes (55% vs 46% and 50%, respectively; P=0.007). No similar differences were observed in women. No significant relationship was observed between FBN1 genotypes and the incidence of cardiovascular disease or all-cause mortality. The increased prevalence of plaque in the carotid artery of middle-aged men with the FBN1 2/3 genotype indicates pathological arterial wall remodelling with a more pronounced atherosclerotic burden. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4875851
- author
- De Basso, Rachel
; Hedblad, Bo
LU
; Carlson, Joyce
LU
; Persson, Margaretha
LU
; Östling, Gerd
LU
and Lanne, Toste
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- arterial wall, blood pressure, cardiovascular risk, human, intima-media, thickness
- in
- Clinical and Experimental Pharmacology and Physiology
- volume
- 41
- issue
- 9
- pages
- 637 - 642
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000344348100004
- scopus:84911147884
- pmid:24837032
- ISSN
- 1440-1681
- DOI
- 10.1111/1440-1681.12259
- language
- English
- LU publication?
- yes
- id
- c98cd643-8548-47b3-affd-72cda9fe48ff (old id 4875851)
- date added to LUP
- 2016-04-01 10:01:10
- date last changed
- 2022-01-25 18:55:03
@article{c98cd643-8548-47b3-affd-72cda9fe48ff,
abstract = {{Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The FBN1 genotype was characterized in 5765 subjects (2424 men, 3341 women; age 45-69years) recruited from the Malmo Diet and Cancer Study Cardiovascular Cohort, Sweden. Plaque occurrence and intima-media thickness (IMT) of the carotid artery were assessed by ultrasound. The incidence of first cardiovascular events (myocardial infarction and stroke) and cause-specific mortality were monitored over a mean follow-up period of 13.2years. The most common FBN1 genotypes were 2/2, 2/3 and 2/4, which accounted for 92.2% (n=5317) of subjects. There were no differences between the three genotypes regarding age, blood pressure, glucose, lipids, smoking habits, common carotid artery diameter and intima-media thickness in men and women. The presence of plaque in the carotid artery was higher in men with the 2/3 genotype compared with the 2/2 and 2/4 genotypes (55% vs 46% and 50%, respectively; P=0.007). No similar differences were observed in women. No significant relationship was observed between FBN1 genotypes and the incidence of cardiovascular disease or all-cause mortality. The increased prevalence of plaque in the carotid artery of middle-aged men with the FBN1 2/3 genotype indicates pathological arterial wall remodelling with a more pronounced atherosclerotic burden.}},
author = {{De Basso, Rachel and Hedblad, Bo and Carlson, Joyce and Persson, Margaretha and Östling, Gerd and Lanne, Toste}},
issn = {{1440-1681}},
keywords = {{arterial wall; blood pressure; cardiovascular risk; human; intima-media; thickness}},
language = {{eng}},
number = {{9}},
pages = {{637--642}},
publisher = {{Wiley-Blackwell}},
series = {{Clinical and Experimental Pharmacology and Physiology}},
title = {{Increased carotid plaque burden in men with the fibrillin-1 2/3 genotype}},
url = {{http://dx.doi.org/10.1111/1440-1681.12259}},
doi = {{10.1111/1440-1681.12259}},
volume = {{41}},
year = {{2014}},
}