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Anticholinergic Load : Is there a Cognitive Cost in Early Parkinson's Disease?

Yarnall, Alison J; Lawson, Rachael A; Duncan, Gordon W; Breen, David P; Khoo, Tien K; Brooks, David; Barker, Roger A LU ; Taylor, John-Paul and Burn, David J (2015) In Journal of Parkinson's Disease 5(4). p.7-743
Abstract

We evaluated the effect of anticholinergic burden on 219 participants with incident Parkinson's disease (PD) and 99 controls at study baseline and 18 months. Anticholinergic burden for each individual was calculated and summed according to the Anticholinergic Drug Scale (ADS). Medication with anticholinergic activity was more commonly prescribed in PD compared to controls, although mean ADS scores were not significantly different. Cognitive scores did not differ in PD participants taking medications with anticholinergic activity compared to those who were not. Low overall ADS scores due to increased awareness of adverse effects of medications and brevity of follow-up are potential explanations.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Aged, Cholinergic Antagonists, Dementia, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mild Cognitive Impairment, Parkinson Disease, Journal Article, Research Support, Non-U.S. Gov't
in
Journal of Parkinson's Disease
volume
5
issue
4
pages
5 pages
publisher
IOS Press
external identifiers
  • scopus:84952653743
ISSN
1877-718X
DOI
10.3233/JPD-150664
language
English
LU publication?
no
id
c98eab16-2f7d-4110-8bba-79d6446d0d39
date added to LUP
2016-11-23 13:26:36
date last changed
2017-01-01 08:40:32
@article{c98eab16-2f7d-4110-8bba-79d6446d0d39,
  abstract     = {<p>We evaluated the effect of anticholinergic burden on 219 participants with incident Parkinson's disease (PD) and 99 controls at study baseline and 18 months. Anticholinergic burden for each individual was calculated and summed according to the Anticholinergic Drug Scale (ADS). Medication with anticholinergic activity was more commonly prescribed in PD compared to controls, although mean ADS scores were not significantly different. Cognitive scores did not differ in PD participants taking medications with anticholinergic activity compared to those who were not. Low overall ADS scores due to increased awareness of adverse effects of medications and brevity of follow-up are potential explanations.</p>},
  author       = {Yarnall, Alison J and Lawson, Rachael A and Duncan, Gordon W and Breen, David P and Khoo, Tien K and Brooks, David and Barker, Roger A and Taylor, John-Paul and Burn, David J},
  issn         = {1877-718X},
  keyword      = {Aged,Cholinergic Antagonists,Dementia,Female,Follow-Up Studies,Humans,Male,Middle Aged,Mild Cognitive Impairment,Parkinson Disease,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {4},
  pages        = {7--743},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Anticholinergic Load : Is there a Cognitive Cost in Early Parkinson's Disease?},
  url          = {http://dx.doi.org/10.3233/JPD-150664},
  volume       = {5},
  year         = {2015},
}