Anticholinergic Load : Is there a Cognitive Cost in Early Parkinson's Disease?
(2015) In Journal of Parkinson's Disease 5(4). p.7-743- Abstract
We evaluated the effect of anticholinergic burden on 219 participants with incident Parkinson's disease (PD) and 99 controls at study baseline and 18 months. Anticholinergic burden for each individual was calculated and summed according to the Anticholinergic Drug Scale (ADS). Medication with anticholinergic activity was more commonly prescribed in PD compared to controls, although mean ADS scores were not significantly different. Cognitive scores did not differ in PD participants taking medications with anticholinergic activity compared to those who were not. Low overall ADS scores due to increased awareness of adverse effects of medications and brevity of follow-up are potential explanations.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c98eab16-2f7d-4110-8bba-79d6446d0d39
- author
- Yarnall, Alison J ; Lawson, Rachael A ; Duncan, Gordon W ; Breen, David P ; Khoo, Tien K ; Brooks, David ; Barker, Roger A LU ; Taylor, John-Paul and Burn, David J
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- keywords
- Aged, Cholinergic Antagonists, Dementia, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mild Cognitive Impairment, Parkinson Disease, Journal Article, Research Support, Non-U.S. Gov't
- in
- Journal of Parkinson's Disease
- volume
- 5
- issue
- 4
- pages
- 5 pages
- publisher
- IOS Press
- external identifiers
-
- scopus:84952653743
- pmid:26444094
- ISSN
- 1877-718X
- DOI
- 10.3233/JPD-150664
- language
- English
- LU publication?
- no
- id
- c98eab16-2f7d-4110-8bba-79d6446d0d39
- date added to LUP
- 2016-11-23 13:26:36
- date last changed
- 2024-11-02 09:07:07
@article{c98eab16-2f7d-4110-8bba-79d6446d0d39, abstract = {{<p>We evaluated the effect of anticholinergic burden on 219 participants with incident Parkinson's disease (PD) and 99 controls at study baseline and 18 months. Anticholinergic burden for each individual was calculated and summed according to the Anticholinergic Drug Scale (ADS). Medication with anticholinergic activity was more commonly prescribed in PD compared to controls, although mean ADS scores were not significantly different. Cognitive scores did not differ in PD participants taking medications with anticholinergic activity compared to those who were not. Low overall ADS scores due to increased awareness of adverse effects of medications and brevity of follow-up are potential explanations.</p>}}, author = {{Yarnall, Alison J and Lawson, Rachael A and Duncan, Gordon W and Breen, David P and Khoo, Tien K and Brooks, David and Barker, Roger A and Taylor, John-Paul and Burn, David J}}, issn = {{1877-718X}}, keywords = {{Aged; Cholinergic Antagonists; Dementia; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mild Cognitive Impairment; Parkinson Disease; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{4}}, pages = {{7--743}}, publisher = {{IOS Press}}, series = {{Journal of Parkinson's Disease}}, title = {{Anticholinergic Load : Is there a Cognitive Cost in Early Parkinson's Disease?}}, url = {{http://dx.doi.org/10.3233/JPD-150664}}, doi = {{10.3233/JPD-150664}}, volume = {{5}}, year = {{2015}}, }