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Renal angioplasty causes a rapid transient increase in inflammatory biomarkers, but reduced levels of interleukin-6 and endothelin-1 1 month after intervention

Alhadad, Alaa LU ; Guron, Gregor ; Fortuna-Nowakowska, Ella ; Saeed, Aso ; Mattiasson, Ingrid LU ; Jensen, Gert ; Lindblad, Bengt LU ; Gottsäter, Anders LU and Herlitz, Hans (2007) In Journal of Hypertension 25(9). p.1907-1914
Abstract

OBJECTIVE: To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. METHODS: One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was ≥10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n = 61) or diagnostic angiography only (n = 39).... (More)

OBJECTIVE: To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. METHODS: One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was ≥10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n = 61) or diagnostic angiography only (n = 39). RESULTS: At baseline there were no significant differences in inflammatory biomarkers or ET-1 levels between patients subsequently undergoing PTRA or angiography only. After angiography, IL-6 and hs-CRP had increased in both groups compared to baseline (P < 0.001). At this time point hs-CRP (10.90 ± 1.48 versus 6.37 ± 1.61 mg/l; P < 0.05) and IL-6 (13.70 ± 0.94 versus 13.00 ± 0.17 pg/ml; P < 0.01) were higher in the PTRA group than in patients subjected to angiography only. One month after PTRA, systolic blood pressure and levels of IL-6 and ET-1 were lower than before intervention (P < 0.05), whereas CD40L had increased compared to baseline (P < 0.01). CONCLUSION: In patients with RAS, PTRA triggers rapid transient increases in hs-CRP and IL-6; however, 1 month after PTRA, both IL-6 and ET-1 had decreased compared to before intervention, indicating beneficial effects of PTRA on inflammation and the endothelin system.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-reactive protein, CD40 ligand, Endothelin-1, Inflammation, Interleukin-6, Neopterin, Percutaneous transluminal renal angioplasty, Renal artery stenosis, Renovascular hypertension, Tumor necrosis factor-α
in
Journal of Hypertension
volume
25
issue
9
pages
1907 - 1914
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:34548394551
  • pmid:17762656
ISSN
0263-6352
DOI
10.1097/HJH.0b013e328244e2ca
language
English
LU publication?
yes
id
ca96ebf8-840a-421f-93d5-599f44849d04
date added to LUP
2020-12-11 14:12:02
date last changed
2021-04-13 01:42:57
@article{ca96ebf8-840a-421f-93d5-599f44849d04,
  abstract     = {<p>OBJECTIVE: To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. METHODS: One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was ≥10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n = 61) or diagnostic angiography only (n = 39). RESULTS: At baseline there were no significant differences in inflammatory biomarkers or ET-1 levels between patients subsequently undergoing PTRA or angiography only. After angiography, IL-6 and hs-CRP had increased in both groups compared to baseline (P &lt; 0.001). At this time point hs-CRP (10.90 ± 1.48 versus 6.37 ± 1.61 mg/l; P &lt; 0.05) and IL-6 (13.70 ± 0.94 versus 13.00 ± 0.17 pg/ml; P &lt; 0.01) were higher in the PTRA group than in patients subjected to angiography only. One month after PTRA, systolic blood pressure and levels of IL-6 and ET-1 were lower than before intervention (P &lt; 0.05), whereas CD40L had increased compared to baseline (P &lt; 0.01). CONCLUSION: In patients with RAS, PTRA triggers rapid transient increases in hs-CRP and IL-6; however, 1 month after PTRA, both IL-6 and ET-1 had decreased compared to before intervention, indicating beneficial effects of PTRA on inflammation and the endothelin system.</p>},
  author       = {Alhadad, Alaa and Guron, Gregor and Fortuna-Nowakowska, Ella and Saeed, Aso and Mattiasson, Ingrid and Jensen, Gert and Lindblad, Bengt and Gottsäter, Anders and Herlitz, Hans},
  issn         = {0263-6352},
  language     = {eng},
  number       = {9},
  pages        = {1907--1914},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Renal angioplasty causes a rapid transient increase in inflammatory biomarkers, but reduced levels of interleukin-6 and endothelin-1 1 month after intervention},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e328244e2ca},
  doi          = {10.1097/HJH.0b013e328244e2ca},
  volume       = {25},
  year         = {2007},
}