Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Menopause is associated with postprandial metabolism, metabolic health and lifestyle : The ZOE PREDICT study

Bermingham, Kate M. ; Linenberg, Inbar ; Hall, Wendy L. ; Kadé, Kirstin ; Franks, Paul W. LU ; Davies, Richard ; Wolf, Jonathan ; Hadjigeorgiou, George ; Asnicar, Francesco and Segata, Nicola , et al. (2022) In EBioMedicine 85.
Abstract

Background: The menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood. Methods: The PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=55, and post-menopausal females n=206) assessed phenotypic characteristics, anthropometric, diet and gut microbiome data, and fasting and postprandial (0–6 h) cardiometabolic blood measurements, including continuous glucose monitoring (CGM) data. Differences between menopausal groups were assessed in the cohort and in an age-matched subgroup, adjusting for age, BMI, menopausal hormone therapy (MHT) use, and smoking status. Findings: Post-menopausal females had higher fasting blood measures... (More)

Background: The menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood. Methods: The PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=55, and post-menopausal females n=206) assessed phenotypic characteristics, anthropometric, diet and gut microbiome data, and fasting and postprandial (0–6 h) cardiometabolic blood measurements, including continuous glucose monitoring (CGM) data. Differences between menopausal groups were assessed in the cohort and in an age-matched subgroup, adjusting for age, BMI, menopausal hormone therapy (MHT) use, and smoking status. Findings: Post-menopausal females had higher fasting blood measures (glucose, HbA1c and inflammation (GlycA), 6%, 5% and 4% respectively), sugar intakes (12%) and poorer sleep (12%) compared with pre-menopausal females (p<0.05 for all). Postprandial metabolic responses for glucose2hiauc and insulin2hiauc were higher (42% and 4% respectively) and CGM measures (glycaemic variability and time in range) were unfavourable post- versus pre-menopause (p<0.05 for all). In age-matched subgroups (n=150), postprandial glucose responses remained higher post-menopause (peak0-2h 4%). MHT was associated with favourable visceral fat, fasting (glucose and insulin) and postprandial (triglyceride6hiauc) measures. Mediation analysis showed that associations between menopause and metabolic health indicators (visceral fat, GlycA360mins and glycaemia (peak0-2h)) were in part mediated by diet and gut bacterial species. Interpretation: Findings from this large scale, in-depth nutrition metabolic study of menopause, support the importance of monitoring risk factors for type-2 diabetes and cardiovascular disease in mid-life to older women to reduce morbidity and mortality associated with oestrogen decline. Funding: Zoe Ltd.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Age-matched subgroups, Menopause, Postprandial metabolic responses
in
EBioMedicine
volume
85
article number
104303
publisher
Elsevier
external identifiers
  • pmid:36270905
  • scopus:85141535919
ISSN
2352-3964
DOI
10.1016/j.ebiom.2022.104303
language
English
LU publication?
yes
id
cad1b6ba-0947-4df4-8a55-7e4993420dc8
date added to LUP
2022-12-01 15:09:04
date last changed
2024-04-18 04:47:02
@article{cad1b6ba-0947-4df4-8a55-7e4993420dc8,
  abstract     = {{<p>Background: The menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood. Methods: The PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=55, and post-menopausal females n=206) assessed phenotypic characteristics, anthropometric, diet and gut microbiome data, and fasting and postprandial (0–6 h) cardiometabolic blood measurements, including continuous glucose monitoring (CGM) data. Differences between menopausal groups were assessed in the cohort and in an age-matched subgroup, adjusting for age, BMI, menopausal hormone therapy (MHT) use, and smoking status. Findings: Post-menopausal females had higher fasting blood measures (glucose, HbA1c and inflammation (GlycA), 6%, 5% and 4% respectively), sugar intakes (12%) and poorer sleep (12%) compared with pre-menopausal females (p&lt;0.05 for all). Postprandial metabolic responses for glucose<sub>2hiauc</sub> and insulin<sub>2hiauc</sub> were higher (42% and 4% respectively) and CGM measures (glycaemic variability and time in range) were unfavourable post- versus pre-menopause (p&lt;0.05 for all). In age-matched subgroups (n=150), postprandial glucose responses remained higher post-menopause (peak<sub>0-2h</sub> 4%). MHT was associated with favourable visceral fat, fasting (glucose and insulin) and postprandial (triglyceride<sub>6hiauc</sub>) measures. Mediation analysis showed that associations between menopause and metabolic health indicators (visceral fat, GlycA<sub>360mins</sub> and glycaemia (peak<sub>0-2h</sub>)) were in part mediated by diet and gut bacterial species. Interpretation: Findings from this large scale, in-depth nutrition metabolic study of menopause, support the importance of monitoring risk factors for type-2 diabetes and cardiovascular disease in mid-life to older women to reduce morbidity and mortality associated with oestrogen decline. Funding: Zoe Ltd.</p>}},
  author       = {{Bermingham, Kate M. and Linenberg, Inbar and Hall, Wendy L. and Kadé, Kirstin and Franks, Paul W. and Davies, Richard and Wolf, Jonathan and Hadjigeorgiou, George and Asnicar, Francesco and Segata, Nicola and Manson, Jo Ann E. and Newson, Louise R. and Delahanty, Linda M. and Ordovas, Jose M. and Chan, Andrew T. and Spector, Tim D. and Valdes, Ana M. and Berry, Sarah E.}},
  issn         = {{2352-3964}},
  keywords     = {{Age-matched subgroups; Menopause; Postprandial metabolic responses}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{EBioMedicine}},
  title        = {{Menopause is associated with postprandial metabolism, metabolic health and lifestyle : The ZOE PREDICT study}},
  url          = {{http://dx.doi.org/10.1016/j.ebiom.2022.104303}},
  doi          = {{10.1016/j.ebiom.2022.104303}},
  volume       = {{85}},
  year         = {{2022}},
}