Relationship between Atrial Oscillatory Acetylcholine Release Pattern and f-wave Frequency Modulation : A Computational and Experimental Study
(2020) 2020 Computing in Cardiology, CinC 2020 In Computing in Cardiology 2020-September.- Abstract
The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded from seven patients during controlled respiration before and after full vagal blockade, from which f-wave frequency modulation was characterized. Computational simulations in human atrial tissues were performed to assess the effects of [ACh] release pattern on Ff and compared to experimental results in humans. A cross-stimulation protocol was... (More)
The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded from seven patients during controlled respiration before and after full vagal blockade, from which f-wave frequency modulation was characterized. Computational simulations in human atrial tissues were performed to assess the effects of [ACh] release pattern on Ff and compared to experimental results in humans. A cross-stimulation protocol was applied onto the tissue to initiate a rotor while cyclically varying [ACh] following a sinusoidal waveform of frequency equal to 0.125 Hz. Different mean levels (0.05, 0.075µM/l) and peak-to-peak ranges (0.1, 0.05, 0.025 µM/l) of [ACh] variation were tested. In all patients, an f-wave frequency modulation could be observed. In 57% of the patients, this modulation was significantly reduced after vagal blockade. Simulations confirmed that rotor frequency variations followed the induced [ACh] patterns. Mean Ff was dependent on mean [ACh] level, while?Ffwas dependent on [ACh] variation range.
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- author
- Celotto, Chiara LU ; Sanchez, Carlos ; Mountris, Konstantinos A. ; Abdollahpur, Mostafa LU ; Sandberg, Frida LU ; Laguna, Pablo and Pucyo, Esther
- organization
- publishing date
- 2020
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- 2020 Computing in Cardiology, CinC 2020
- series title
- Computing in Cardiology
- volume
- 2020-September
- article number
- 9344122
- publisher
- IEEE Computer Society
- conference name
- 2020 Computing in Cardiology, CinC 2020
- conference location
- Rimini, Italy
- conference dates
- 2020-09-13 - 2020-09-16
- external identifiers
-
- scopus:85100918513
- ISSN
- 2325-887X
- 2325-8861
- ISBN
- 9781728173825
- DOI
- 10.22489/CinC.2020.303
- project
- Ph.D. project: Risk stratification and prediction of intervention outcome in AF using novel ECG-based markers of atrial remodelling
- Diagnostic Biomarkers in Atrial Fibrillation - Autonomic Nervous System Response as a Sign of Disease Progression
- language
- English
- LU publication?
- yes
- id
- cad796ad-10d8-49b7-a4d3-f4d2e5ef1c03
- date added to LUP
- 2021-03-05 11:13:37
- date last changed
- 2024-06-13 08:13:04
@inproceedings{cad796ad-10d8-49b7-a4d3-f4d2e5ef1c03, abstract = {{<p>The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded from seven patients during controlled respiration before and after full vagal blockade, from which f-wave frequency modulation was characterized. Computational simulations in human atrial tissues were performed to assess the effects of [ACh] release pattern on Ff and compared to experimental results in humans. A cross-stimulation protocol was applied onto the tissue to initiate a rotor while cyclically varying [ACh] following a sinusoidal waveform of frequency equal to 0.125 Hz. Different mean levels (0.05, 0.075µM/l) and peak-to-peak ranges (0.1, 0.05, 0.025 µM/l) of [ACh] variation were tested. In all patients, an f-wave frequency modulation could be observed. In 57% of the patients, this modulation was significantly reduced after vagal blockade. Simulations confirmed that rotor frequency variations followed the induced [ACh] patterns. Mean Ff was dependent on mean [ACh] level, while?Ffwas dependent on [ACh] variation range.</p>}}, author = {{Celotto, Chiara and Sanchez, Carlos and Mountris, Konstantinos A. and Abdollahpur, Mostafa and Sandberg, Frida and Laguna, Pablo and Pucyo, Esther}}, booktitle = {{2020 Computing in Cardiology, CinC 2020}}, isbn = {{9781728173825}}, issn = {{2325-887X}}, language = {{eng}}, publisher = {{IEEE Computer Society}}, series = {{Computing in Cardiology}}, title = {{Relationship between Atrial Oscillatory Acetylcholine Release Pattern and f-wave Frequency Modulation : A Computational and Experimental Study}}, url = {{https://lup.lub.lu.se/search/files/95172893/Relationship_Between_Atrial_Oscillatory_Acetylcholine_Release_Pattern_and_f_wave_Frequency_Modulation_a_Computational_and_Experimental_Study.pdf}}, doi = {{10.22489/CinC.2020.303}}, volume = {{2020-September}}, year = {{2020}}, }