Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Relationship between Atrial Oscillatory Acetylcholine Release Pattern and f-wave Frequency Modulation : A Computational and Experimental Study

Celotto, Chiara LU ; Sanchez, Carlos ; Mountris, Konstantinos A. ; Abdollahpur, Mostafa LU ; Sandberg, Frida LU ; Laguna, Pablo and Pucyo, Esther (2020) 2020 Computing in Cardiology, CinC 2020 In Computing in Cardiology 2020-September.
Abstract

The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded from seven patients during controlled respiration before and after full vagal blockade, from which f-wave frequency modulation was characterized. Computational simulations in human atrial tissues were performed to assess the effects of [ACh] release pattern on Ff and compared to experimental results in humans. A cross-stimulation protocol was... (More)

The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded from seven patients during controlled respiration before and after full vagal blockade, from which f-wave frequency modulation was characterized. Computational simulations in human atrial tissues were performed to assess the effects of [ACh] release pattern on Ff and compared to experimental results in humans. A cross-stimulation protocol was applied onto the tissue to initiate a rotor while cyclically varying [ACh] following a sinusoidal waveform of frequency equal to 0.125 Hz. Different mean levels (0.05, 0.075µM/l) and peak-to-peak ranges (0.1, 0.05, 0.025 µM/l) of [ACh] variation were tested. In all patients, an f-wave frequency modulation could be observed. In 57% of the patients, this modulation was significantly reduced after vagal blockade. Simulations confirmed that rotor frequency variations followed the induced [ACh] patterns. Mean Ff was dependent on mean [ACh] level, while?Ffwas dependent on [ACh] variation range.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
2020 Computing in Cardiology, CinC 2020
series title
Computing in Cardiology
volume
2020-September
article number
9344122
publisher
IEEE Computer Society
conference name
2020 Computing in Cardiology, CinC 2020
conference location
Rimini, Italy
conference dates
2020-09-13 - 2020-09-16
external identifiers
  • scopus:85100918513
ISSN
2325-887X
2325-8861
ISBN
9781728173825
DOI
10.22489/CinC.2020.303
project
Ph.D. project: Risk stratification and prediction of intervention outcome in AF using novel ECG-based markers of atrial remodelling
Diagnostic Biomarkers in Atrial Fibrillation - Autonomic Nervous System Response as a Sign of Disease Progression
language
English
LU publication?
yes
id
cad796ad-10d8-49b7-a4d3-f4d2e5ef1c03
date added to LUP
2021-03-05 11:13:37
date last changed
2024-01-18 00:48:43
@inproceedings{cad796ad-10d8-49b7-a4d3-f4d2e5ef1c03,
  abstract     = {{<p>The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded from seven patients during controlled respiration before and after full vagal blockade, from which f-wave frequency modulation was characterized. Computational simulations in human atrial tissues were performed to assess the effects of [ACh] release pattern on Ff and compared to experimental results in humans. A cross-stimulation protocol was applied onto the tissue to initiate a rotor while cyclically varying [ACh] following a sinusoidal waveform of frequency equal to 0.125 Hz. Different mean levels (0.05, 0.075µM/l) and peak-to-peak ranges (0.1, 0.05, 0.025 µM/l) of [ACh] variation were tested. In all patients, an f-wave frequency modulation could be observed. In 57% of the patients, this modulation was significantly reduced after vagal blockade. Simulations confirmed that rotor frequency variations followed the induced [ACh] patterns. Mean Ff was dependent on mean [ACh] level, while?Ffwas dependent on [ACh] variation range.</p>}},
  author       = {{Celotto, Chiara and Sanchez, Carlos and Mountris, Konstantinos A. and Abdollahpur, Mostafa and Sandberg, Frida and Laguna, Pablo and Pucyo, Esther}},
  booktitle    = {{2020 Computing in Cardiology, CinC 2020}},
  isbn         = {{9781728173825}},
  issn         = {{2325-887X}},
  language     = {{eng}},
  publisher    = {{IEEE Computer Society}},
  series       = {{Computing in Cardiology}},
  title        = {{Relationship between Atrial Oscillatory Acetylcholine Release Pattern and f-wave Frequency Modulation : A Computational and Experimental Study}},
  url          = {{https://lup.lub.lu.se/search/files/95172893/Relationship_Between_Atrial_Oscillatory_Acetylcholine_Release_Pattern_and_f_wave_Frequency_Modulation_a_Computational_and_Experimental_Study.pdf}},
  doi          = {{10.22489/CinC.2020.303}},
  volume       = {{2020-September}},
  year         = {{2020}},
}