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Functional connectivity in behavioral variant frontotemporal dementia

Ferreira, Luiz Kobuti ; Lindberg, Olof LU ; Santillo, Alexander F. LU orcid and Wahlund, Lars Olof (2022) In Brain and Behavior 12(12).
Abstract

Introduction: Functional connectivity (FC)—which reflects relationships between neural activity in different brain regions—has been used to explore the functional architecture of the brain in neurodegenerative disorders. Although an increasing number of studies have explored FC changes in behavioral variant frontotemporal dementia (bvFTD), there is no focused, in-depth review about FC in bvFTD. Methods: Comprehensive literature search and narrative review to summarize the current field of FC in bvFTD. Results: (1) Decreased FC within the salience network (SN) is the most consistent finding in bvFTD; (2) FC changes extend beyond the SN and affect the interplay between networks; (3) results within the Default Mode Network are mixed; (4)... (More)

Introduction: Functional connectivity (FC)—which reflects relationships between neural activity in different brain regions—has been used to explore the functional architecture of the brain in neurodegenerative disorders. Although an increasing number of studies have explored FC changes in behavioral variant frontotemporal dementia (bvFTD), there is no focused, in-depth review about FC in bvFTD. Methods: Comprehensive literature search and narrative review to summarize the current field of FC in bvFTD. Results: (1) Decreased FC within the salience network (SN) is the most consistent finding in bvFTD; (2) FC changes extend beyond the SN and affect the interplay between networks; (3) results within the Default Mode Network are mixed; (4) the brain as a network is less interconnected and less efficient in bvFTD; (5) symptoms, functional impairment, and cognition are associated with FC; and (6) the functional architecture resembles patterns of neuropathological spread. Conclusions: FC has potential as a biomarker, and future studies are expected to advance the field with multicentric initiatives, longitudinal designs, and methodological advances.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brain, bvFTD, fMRI, frontotemporal dementia, functional connectivity
in
Brain and Behavior
volume
12
issue
12
article number
e2790
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:36306386
  • scopus:85141353139
ISSN
2162-3279
DOI
10.1002/brb3.2790
language
English
LU publication?
yes
additional info
Funding Information: Alexander F. Santillo has been supported by funds from Lund University, Region Skåne and The Schörling Foundation. Publisher Copyright: © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
id
cb0d417c-9f53-4181-891a-0fcebaa023de
date added to LUP
2022-11-24 19:43:15
date last changed
2025-03-08 19:48:51
@article{cb0d417c-9f53-4181-891a-0fcebaa023de,
  abstract     = {{<p>Introduction: Functional connectivity (FC)—which reflects relationships between neural activity in different brain regions—has been used to explore the functional architecture of the brain in neurodegenerative disorders. Although an increasing number of studies have explored FC changes in behavioral variant frontotemporal dementia (bvFTD), there is no focused, in-depth review about FC in bvFTD. Methods: Comprehensive literature search and narrative review to summarize the current field of FC in bvFTD. Results: (1) Decreased FC within the salience network (SN) is the most consistent finding in bvFTD; (2) FC changes extend beyond the SN and affect the interplay between networks; (3) results within the Default Mode Network are mixed; (4) the brain as a network is less interconnected and less efficient in bvFTD; (5) symptoms, functional impairment, and cognition are associated with FC; and (6) the functional architecture resembles patterns of neuropathological spread. Conclusions: FC has potential as a biomarker, and future studies are expected to advance the field with multicentric initiatives, longitudinal designs, and methodological advances.</p>}},
  author       = {{Ferreira, Luiz Kobuti and Lindberg, Olof and Santillo, Alexander F. and Wahlund, Lars Olof}},
  issn         = {{2162-3279}},
  keywords     = {{brain; bvFTD; fMRI; frontotemporal dementia; functional connectivity}},
  language     = {{eng}},
  number       = {{12}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Brain and Behavior}},
  title        = {{Functional connectivity in behavioral variant frontotemporal dementia}},
  url          = {{http://dx.doi.org/10.1002/brb3.2790}},
  doi          = {{10.1002/brb3.2790}},
  volume       = {{12}},
  year         = {{2022}},
}