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Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

Du, Ting ; Mestre, Humberto ; Kress, Benjamin T. ; Liu, Guojun ; Sweeney, Amanda M. ; Samson, Andrew J. ; Rasmussen, Martin Kaag ; Mortensen, Kristian Nygaard ; Bork, Peter A.R. and Peng, Weiguo , et al. (2022) In Brain : a journal of neurology 145(2). p.787-797
Abstract

Cerebral oedema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that oedema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of CSF. Oedema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of oedema. Oedema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect... (More)

Cerebral oedema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that oedema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of CSF. Oedema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of oedema. Oedema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect of therapeutic hypothermia. These observations show that CSF is a primary source of oedema fluid in anoxic brain. This novel insight offers a mechanistic basis for the future development of alternative strategies to prevent cerebral oedema formation after cardiac arrest.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anoxic cerebral oedema, cardiac arrest, cerebrospinal fluid, spreading depolarizations
in
Brain : a journal of neurology
volume
145
issue
2
article number
awab293
pages
11 pages
publisher
Oxford University Press
external identifiers
  • pmid:34581781
  • scopus:85128493919
ISSN
1460-2156
DOI
10.1093/brain/awab293
language
English
LU publication?
yes
id
cb0d6b69-0cef-4ad6-902d-205f8c23f547
date added to LUP
2022-05-03 10:37:47
date last changed
2025-03-08 18:39:06
@article{cb0d6b69-0cef-4ad6-902d-205f8c23f547,
  abstract     = {{<p>Cerebral oedema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that oedema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of CSF. Oedema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of oedema. Oedema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect of therapeutic hypothermia. These observations show that CSF is a primary source of oedema fluid in anoxic brain. This novel insight offers a mechanistic basis for the future development of alternative strategies to prevent cerebral oedema formation after cardiac arrest.</p>}},
  author       = {{Du, Ting and Mestre, Humberto and Kress, Benjamin T. and Liu, Guojun and Sweeney, Amanda M. and Samson, Andrew J. and Rasmussen, Martin Kaag and Mortensen, Kristian Nygaard and Bork, Peter A.R. and Peng, Weiguo and Olveda, Genaro E. and Bashford, Logan and Toro, Edna R. and Tithof, Jeffrey and Kelley, Douglas H. and Thomas, John H. and Hjorth, Poul G. and Martens, Erik A. and Mehta, Rupal I. and Hirase, Hajime and Mori, Yuki and Nedergaard, Maiken}},
  issn         = {{1460-2156}},
  keywords     = {{anoxic cerebral oedema; cardiac arrest; cerebrospinal fluid; spreading depolarizations}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{2}},
  pages        = {{787--797}},
  publisher    = {{Oxford University Press}},
  series       = {{Brain : a journal of neurology}},
  title        = {{Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema}},
  url          = {{http://dx.doi.org/10.1093/brain/awab293}},
  doi          = {{10.1093/brain/awab293}},
  volume       = {{145}},
  year         = {{2022}},
}