Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2 : the BRCA1 and BRCA2 Cohort Consortium
(2023) In Breast cancer research : BCR 25(1).- Abstract
INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes.
PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change.
RESULTS: In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for BRCA2 variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04-1.38). Higher... (More)
INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes.
PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change.
RESULTS: In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for BRCA2 variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04-1.38). Higher young-adult BMI was associated with lower premenopausal breast cancer risk for both BRCA1 (HR 0.75 per 5 kg/m2, 95% CI 0.66-0.84) and BRCA2 (HR 0.76, 95% CI 0.65-0.89) variant carriers in the retrospective analysis, with consistent, though not statistically significant, findings from the prospective analysis. In the prospective analysis, higher BMI and adult weight gain were associated with higher postmenopausal breast cancer risk for BRCA1 carriers (HR 1.20 per 5 kg/m2, 95% CI 1.02-1.42; and HR 1.10 per 5 kg weight gain, 95% CI 1.01-1.19, respectively).
CONCLUSION: Anthropometric measures are associated with breast cancer risk for BRCA1 and BRCA2 variant carriers, with relative risk estimates that are generally consistent with those for women from the general population.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2023-06-20
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Female, Humans, Body Mass Index, Genes, BRCA2, BRCA1 Protein/genetics, Breast Neoplasms/epidemiology, BRCA2 Protein/genetics, Risk, Retrospective Studies, Weight Gain/genetics, Heterozygote, Genetic Predisposition to Disease
- in
- Breast cancer research : BCR
- volume
- 25
- issue
- 1
- article number
- 72
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85162932832
- pmid:37340476
- ISSN
- 1465-5411
- DOI
- 10.1186/s13058-023-01673-w
- language
- English
- LU publication?
- yes
- additional info
- © 2023. The Author(s).
- id
- cbb7dd91-5526-4c44-8b6e-1e21c49490ef
- date added to LUP
- 2023-11-11 15:57:43
- date last changed
- 2024-04-23 19:38:50
@article{cbb7dd91-5526-4c44-8b6e-1e21c49490ef,
abstract = {{<p>INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes.</p><p>PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change.</p><p>RESULTS: In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for BRCA2 variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04-1.38). Higher young-adult BMI was associated with lower premenopausal breast cancer risk for both BRCA1 (HR 0.75 per 5 kg/m2, 95% CI 0.66-0.84) and BRCA2 (HR 0.76, 95% CI 0.65-0.89) variant carriers in the retrospective analysis, with consistent, though not statistically significant, findings from the prospective analysis. In the prospective analysis, higher BMI and adult weight gain were associated with higher postmenopausal breast cancer risk for BRCA1 carriers (HR 1.20 per 5 kg/m2, 95% CI 1.02-1.42; and HR 1.10 per 5 kg weight gain, 95% CI 1.01-1.19, respectively).</p><p>CONCLUSION: Anthropometric measures are associated with breast cancer risk for BRCA1 and BRCA2 variant carriers, with relative risk estimates that are generally consistent with those for women from the general population.</p>}},
author = {{Kast, Karin and van de Beek, Irma and Olah, Edith and Jakubowska, Anna and Singer, Christian F and Tan, Yen and Augustinsson, Annelie and Milne, Roger L and Phillips, Kelly-Anne and Terry, Mary Beth and Goldgar, David and van Leeuwen, Flora E and Mooij, Thea M and Antoniou, Antonis C and Engel, Christoph}},
issn = {{1465-5411}},
keywords = {{Adult; Female; Humans; Body Mass Index; Genes, BRCA2; BRCA1 Protein/genetics; Breast Neoplasms/epidemiology; BRCA2 Protein/genetics; Risk; Retrospective Studies; Weight Gain/genetics; Heterozygote; Genetic Predisposition to Disease}},
language = {{eng}},
month = {{06}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Breast cancer research : BCR}},
title = {{Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2 : the BRCA1 and BRCA2 Cohort Consortium}},
url = {{http://dx.doi.org/10.1186/s13058-023-01673-w}},
doi = {{10.1186/s13058-023-01673-w}},
volume = {{25}},
year = {{2023}},
}