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A Scoping Review on The Use of Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-Of-Hospital Cardiac Arrest

Nikolov, Kalina ; Wagner, Henrik LU and Madsen Härdig, Bjarne LU orcid (2023) In International Journal of Clinical Cardiology and Cardiovascular Interventions 2(4). p.1-14
Abstract
Aim of the review: To provide an overview of studies that have published data
regarding region and population size, procedure location, team composition, inclusion
and exclusion criteria, outcome parameters, and cost–benefit analyses on
extracorporeal membrane oxygenation use for refractory out-of-hospital cardiac arrest.
Data sources: A structured systematic literature search of articles published prior to
April 27, 2021, was performed in online databases (PubMed, EMBASE,
ClinicalTrials.gov, the EU Clinical Trials Register, and Cochrane Library).
Results: Sixty-three articles were included based on predefined eligibility criteria. The
included articles were published between 2011 and 2021, with the highest... (More)
Aim of the review: To provide an overview of studies that have published data
regarding region and population size, procedure location, team composition, inclusion
and exclusion criteria, outcome parameters, and cost–benefit analyses on
extracorporeal membrane oxygenation use for refractory out-of-hospital cardiac arrest.
Data sources: A structured systematic literature search of articles published prior to
April 27, 2021, was performed in online databases (PubMed, EMBASE,
ClinicalTrials.gov, the EU Clinical Trials Register, and Cochrane Library).
Results: Sixty-three articles were included based on predefined eligibility criteria. The
included articles were published between 2011 and 2021, with the highest number of
articles in 2020 and 2021 (50%). Of the 58 articles that reported data on organisational
topics, 47 reported transporting the patients to the hospital for cannulation, 10 reported
initiating extracorporeal cardiopulmonary resuscitation (ECPR) on-scene, and one
reported doing both. The most common inclusion criterion was a lower age limit of 18
years (in 86% of the articles). Other inclusion criteria were witnessed collapse (67%)
and initial ventricular fibrillation/tachycardia (43%), asystole (3%), pulseless electrical
activity (5%), pulmonary embolism (2%), and signs of life during CPR (5%). The most
common exclusion criterion was a do-not-resuscitate order (38%). Of the 44 studies
reporting outcomes, 77% reported survival to hospital discharge and 50%, a cerebral
performance category score of 1-2. Other outcome parameters were sparsely reported.
Conclusion: There is a variation in regional size, team composition, inclusion and
exclusion criteria and reported outcomes. These discrepancies make it challenging to
determine how to effectively use ECPR (Less)
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publication status
published
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in
International Journal of Clinical Cardiology and Cardiovascular Interventions
volume
2
issue
4
pages
1 - 14
DOI
10.61148/2836-2837/IJCCCI/010
language
English
LU publication?
yes
id
cbc924e0-9bf7-47e0-b0ed-f451fc0f2c51
date added to LUP
2025-06-27 11:10:42
date last changed
2025-06-30 07:39:59
@article{cbc924e0-9bf7-47e0-b0ed-f451fc0f2c51,
  abstract     = {{Aim of the review: To provide an overview of studies that have published data<br/>regarding region and population size, procedure location, team composition, inclusion<br/>and exclusion criteria, outcome parameters, and cost–benefit analyses on<br/>extracorporeal membrane oxygenation use for refractory out-of-hospital cardiac arrest.<br/>Data sources: A structured systematic literature search of articles published prior to<br/>April 27, 2021, was performed in online databases (PubMed, EMBASE,<br/>ClinicalTrials.gov, the EU Clinical Trials Register, and Cochrane Library).<br/>Results: Sixty-three articles were included based on predefined eligibility criteria. The<br/>included articles were published between 2011 and 2021, with the highest number of<br/>articles in 2020 and 2021 (50%). Of the 58 articles that reported data on organisational<br/>topics, 47 reported transporting the patients to the hospital for cannulation, 10 reported<br/>initiating extracorporeal cardiopulmonary resuscitation (ECPR) on-scene, and one<br/>reported doing both. The most common inclusion criterion was a lower age limit of 18<br/>years (in 86% of the articles). Other inclusion criteria were witnessed collapse (67%)<br/>and initial ventricular fibrillation/tachycardia (43%), asystole (3%), pulseless electrical<br/>activity (5%), pulmonary embolism (2%), and signs of life during CPR (5%). The most<br/>common exclusion criterion was a do-not-resuscitate order (38%). Of the 44 studies<br/>reporting outcomes, 77% reported survival to hospital discharge and 50%, a cerebral<br/>performance category score of 1-2. Other outcome parameters were sparsely reported.<br/>Conclusion: There is a variation in regional size, team composition, inclusion and<br/>exclusion criteria and reported outcomes. These discrepancies make it challenging to<br/>determine how to effectively use ECPR}},
  author       = {{Nikolov, Kalina and Wagner, Henrik and Madsen Härdig, Bjarne}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1--14}},
  series       = {{International Journal of Clinical Cardiology and Cardiovascular Interventions}},
  title        = {{A Scoping Review on The Use of Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-Of-Hospital Cardiac Arrest}},
  url          = {{http://dx.doi.org/10.61148/2836-2837/IJCCCI/010}},
  doi          = {{10.61148/2836-2837/IJCCCI/010}},
  volume       = {{2}},
  year         = {{2023}},
}