Antimicrobial activity of fibrinogen and fibrinogen-derived peptides - a novel link between coagulation and innate immunity.
Påhlman, Lisa LU ; Mörgelin, Matthias LU ; Kasetty, Gopinath LU ; Olin, Anders LU ; Schmidtchen, Artur LU and Herwald, Heiko LU
(2013)
In Thrombosis and Haemostasis
109(5).
p.930-939
- Abstract
- Fibrinogen is a key player in the blood coagulation system, and is upon activation with thrombin converted into fibrin that subsequently forms a fibrin clot. In the present study, we investigated the role of fibrinogen in the early innate immune response. Here we show that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin. Moreover, we found that the peptide fragment GHR28 released from the β-chain of fibrinogen has antimicrobial activity against bacteria that bind fibrinogen to their surface, whereas non-binding strains are unaffected. Notably, bacterial killing was detected in Group A Streptococcus bacteria entrapped in a fibrin clot, suggesting that fibrinogen and coagulation is involved in... (More)
- Fibrinogen is a key player in the blood coagulation system, and is upon activation with thrombin converted into fibrin that subsequently forms a fibrin clot. In the present study, we investigated the role of fibrinogen in the early innate immune response. Here we show that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin. Moreover, we found that the peptide fragment GHR28 released from the β-chain of fibrinogen has antimicrobial activity against bacteria that bind fibrinogen to their surface, whereas non-binding strains are unaffected. Notably, bacterial killing was detected in Group A Streptococcus bacteria entrapped in a fibrin clot, suggesting that fibrinogen and coagulation is involved in the early innate immune system to quickly wall off and neutralise invading pathogens. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3628498
- author
- Påhlman, Lisa
LU
; Mörgelin, Matthias
LU
; Kasetty, Gopinath
LU
; Olin, Anders
LU
; Schmidtchen, Artur
LU
and Herwald, Heiko
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thrombosis and Haemostasis
- volume
- 109
- issue
- 5
- pages
- 930 - 939
- publisher
- Schattauer GmbH
- external identifiers
-
- wos:000318755500020
- pmid:23467586
- scopus:84877080275
- pmid:23467586
- ISSN
- 0340-6245
- DOI
- 10.1160/TH12-10-0739
- language
- English
- LU publication?
- yes
- id
- cbe7d7d6-9891-42f1-b99e-11df54a39c68 (old id 3628498)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23467586?dopt=Abstract
- date added to LUP
- 2016-04-01 13:06:35
- date last changed
- 2022-03-29 05:34:18
@article{cbe7d7d6-9891-42f1-b99e-11df54a39c68,
abstract = {{Fibrinogen is a key player in the blood coagulation system, and is upon activation with thrombin converted into fibrin that subsequently forms a fibrin clot. In the present study, we investigated the role of fibrinogen in the early innate immune response. Here we show that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin. Moreover, we found that the peptide fragment GHR28 released from the β-chain of fibrinogen has antimicrobial activity against bacteria that bind fibrinogen to their surface, whereas non-binding strains are unaffected. Notably, bacterial killing was detected in Group A Streptococcus bacteria entrapped in a fibrin clot, suggesting that fibrinogen and coagulation is involved in the early innate immune system to quickly wall off and neutralise invading pathogens.}},
author = {{Påhlman, Lisa and Mörgelin, Matthias and Kasetty, Gopinath and Olin, Anders and Schmidtchen, Artur and Herwald, Heiko}},
issn = {{0340-6245}},
language = {{eng}},
number = {{5}},
pages = {{930--939}},
publisher = {{Schattauer GmbH}},
series = {{Thrombosis and Haemostasis}},
title = {{Antimicrobial activity of fibrinogen and fibrinogen-derived peptides - a novel link between coagulation and innate immunity.}},
url = {{http://dx.doi.org/10.1160/TH12-10-0739}},
doi = {{10.1160/TH12-10-0739}},
volume = {{109}},
year = {{2013}},
}