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Antimicrobial activity of fibrinogen and fibrinogen-derived peptides - a novel link between coagulation and innate immunity.

Påhlman, Lisa LU ; Mörgelin, Matthias LU ; Kasetty, Gopinath LU ; Olin, Anders LU ; Schmidtchen, Artur LU and Herwald, Heiko LU (2013) In Thrombosis and Haemostasis 109(5). p.930-939
Abstract
Fibrinogen is a key player in the blood coagulation system, and is upon activation with thrombin converted into fibrin that subsequently forms a fibrin clot. In the present study, we investigated the role of fibrinogen in the early innate immune response. Here we show that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin. Moreover, we found that the peptide fragment GHR28 released from the β-chain of fibrinogen has antimicrobial activity against bacteria that bind fibrinogen to their surface, whereas non-binding strains are unaffected. Notably, bacterial killing was detected in Group A Streptococcus bacteria entrapped in a fibrin clot, suggesting that fibrinogen and coagulation is involved in... (More)
Fibrinogen is a key player in the blood coagulation system, and is upon activation with thrombin converted into fibrin that subsequently forms a fibrin clot. In the present study, we investigated the role of fibrinogen in the early innate immune response. Here we show that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin. Moreover, we found that the peptide fragment GHR28 released from the β-chain of fibrinogen has antimicrobial activity against bacteria that bind fibrinogen to their surface, whereas non-binding strains are unaffected. Notably, bacterial killing was detected in Group A Streptococcus bacteria entrapped in a fibrin clot, suggesting that fibrinogen and coagulation is involved in the early innate immune system to quickly wall off and neutralise invading pathogens. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis and Haemostasis
volume
109
issue
5
pages
930 - 939
publisher
F K Schattauer Verlag Gmbh
external identifiers
  • wos:000318755500020
  • pmid:23467586
  • scopus:84877080275
ISSN
0340-6245
DOI
10.1160/TH12-10-0739
language
English
LU publication?
yes
id
cbe7d7d6-9891-42f1-b99e-11df54a39c68 (old id 3628498)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23467586?dopt=Abstract
date added to LUP
2013-04-04 14:02:59
date last changed
2019-10-08 01:43:27
@article{cbe7d7d6-9891-42f1-b99e-11df54a39c68,
  abstract     = {Fibrinogen is a key player in the blood coagulation system, and is upon activation with thrombin converted into fibrin that subsequently forms a fibrin clot. In the present study, we investigated the role of fibrinogen in the early innate immune response. Here we show that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin. Moreover, we found that the peptide fragment GHR28 released from the β-chain of fibrinogen has antimicrobial activity against bacteria that bind fibrinogen to their surface, whereas non-binding strains are unaffected. Notably, bacterial killing was detected in Group A Streptococcus bacteria entrapped in a fibrin clot, suggesting that fibrinogen and coagulation is involved in the early innate immune system to quickly wall off and neutralise invading pathogens.},
  author       = {Påhlman, Lisa and Mörgelin, Matthias and Kasetty, Gopinath and Olin, Anders and Schmidtchen, Artur and Herwald, Heiko},
  issn         = {0340-6245},
  language     = {eng},
  number       = {5},
  pages        = {930--939},
  publisher    = {F K Schattauer Verlag Gmbh},
  series       = {Thrombosis and Haemostasis},
  title        = {Antimicrobial activity of fibrinogen and fibrinogen-derived peptides - a novel link between coagulation and innate immunity.},
  url          = {http://dx.doi.org/10.1160/TH12-10-0739},
  volume       = {109},
  year         = {2013},
}