Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Decline of HPV infections in Scandinavian cervical screening populations after introduction of HPV vaccination programs

Dillner, Joakim LU ; Nygård, Mari ; Munk, Christian ; Hortlund, Maria LU ; Hansen, Bo T. ; Lagheden, Camilla LU ; Liaw, Kai Li and Kjaer, Susanne K. (2018) In Vaccine
Abstract

Objective: To monitor the changes in prevalence of human papillomavirus (HPV) infections in women <50 years of age, participating in cervical screening programs of Denmark, Norway, and Sweden, before and after introduction of quadrivalent HPV (qHPV) vaccination. Methods: Liquid-based cytology samples were collected from 6538 women who attended cervical screening in Denmark, Norway, and Sweden in 2006–2008 and from 6332 similarly enrolled women in 2012–2013. Denmark started organized qHPV vaccination in 2008, Norway in 2009, and Sweden in 2012. All HPV testing and genotyping was performed using identical enrollment and analysis methods, by accredited general primer polymerase chain reaction methods with typing using the Luminex... (More)

Objective: To monitor the changes in prevalence of human papillomavirus (HPV) infections in women <50 years of age, participating in cervical screening programs of Denmark, Norway, and Sweden, before and after introduction of quadrivalent HPV (qHPV) vaccination. Methods: Liquid-based cytology samples were collected from 6538 women who attended cervical screening in Denmark, Norway, and Sweden in 2006–2008 and from 6332 similarly enrolled women in 2012–2013. Denmark started organized qHPV vaccination in 2008, Norway in 2009, and Sweden in 2012. All HPV testing and genotyping was performed using identical enrollment and analysis methods, by accredited general primer polymerase chain reaction methods with typing using the Luminex system. Results: Overall HPV positivity declined slightly from 36.5% in 2006–2008 to 34.5% in 2012–2013. The decline was most pronounced among women 18–26 years of age: from 54.4% to 48.1% (P < 0.001). The decline was substantial for vaccine HPV types (HPV6/11/16/18: decline from 22.3% to 16.6%; P < 0.001) and was seen for both low-risk vaccine types (HPV6/11 declined from 5.0% to 2.5%) and high-risk vaccine types (HPV16/18 declined from 18.9% to 14.9%). Among women 27–50 years of age, there was no change between the time periods (22.5% and 21.6%, respectively). The significant decline in the younger age group was different in the 3 countries. Conclusion: This population-based study enrolling >12,000 women participating in cervical screening in the 3 Nordic countries before and after introduction of organized qHPV vaccination demonstrated a marked decline in HPV infection in the younger population in the 2 countries where qHPV vaccination programs started in 2008–2009, suggesting that organized HPV vaccination programs resulted in a decrease of HPV types circulating in the general population.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Human papillomavirus, Liquid-based cytology, Quadrivalent HPV vaccine, Scandinavia, Type-specific HPV
in
Vaccine
publisher
Elsevier
external identifiers
  • scopus:85046881596
ISSN
0264-410X
language
English
LU publication?
no
id
cc273b76-af68-43ed-9c4a-1124a8e8240c
date added to LUP
2018-05-25 14:19:52
date last changed
2022-07-12 10:11:44
@article{cc273b76-af68-43ed-9c4a-1124a8e8240c,
  abstract     = {{<p>Objective: To monitor the changes in prevalence of human papillomavirus (HPV) infections in women &lt;50 years of age, participating in cervical screening programs of Denmark, Norway, and Sweden, before and after introduction of quadrivalent HPV (qHPV) vaccination. Methods: Liquid-based cytology samples were collected from 6538 women who attended cervical screening in Denmark, Norway, and Sweden in 2006–2008 and from 6332 similarly enrolled women in 2012–2013. Denmark started organized qHPV vaccination in 2008, Norway in 2009, and Sweden in 2012. All HPV testing and genotyping was performed using identical enrollment and analysis methods, by accredited general primer polymerase chain reaction methods with typing using the Luminex system. Results: Overall HPV positivity declined slightly from 36.5% in 2006–2008 to 34.5% in 2012–2013. The decline was most pronounced among women 18–26 years of age: from 54.4% to 48.1% (P &lt; 0.001). The decline was substantial for vaccine HPV types (HPV6/11/16/18: decline from 22.3% to 16.6%; P &lt; 0.001) and was seen for both low-risk vaccine types (HPV6/11 declined from 5.0% to 2.5%) and high-risk vaccine types (HPV16/18 declined from 18.9% to 14.9%). Among women 27–50 years of age, there was no change between the time periods (22.5% and 21.6%, respectively). The significant decline in the younger age group was different in the 3 countries. Conclusion: This population-based study enrolling &gt;12,000 women participating in cervical screening in the 3 Nordic countries before and after introduction of organized qHPV vaccination demonstrated a marked decline in HPV infection in the younger population in the 2 countries where qHPV vaccination programs started in 2008–2009, suggesting that organized HPV vaccination programs resulted in a decrease of HPV types circulating in the general population.</p>}},
  author       = {{Dillner, Joakim and Nygård, Mari and Munk, Christian and Hortlund, Maria and Hansen, Bo T. and Lagheden, Camilla and Liaw, Kai Li and Kjaer, Susanne K.}},
  issn         = {{0264-410X}},
  keywords     = {{Human papillomavirus; Liquid-based cytology; Quadrivalent HPV vaccine; Scandinavia; Type-specific HPV}},
  language     = {{eng}},
  month        = {{01}},
  publisher    = {{Elsevier}},
  series       = {{Vaccine}},
  title        = {{Decline of HPV infections in Scandinavian cervical screening populations after introduction of HPV vaccination programs}},
  year         = {{2018}},
}