Serum cathepsin B activity during regression of Morris hepatoma 5123 D
Fedorowski, Artur LU
; Steciwko, Andrzej
and Rabczyński, Jerzy
(2004)
In Medical Science Monitor
10(5).
p.50-144
- Abstract
BACKGROUND: Serum cathepsin B activity has been considered a potential marker of tumor progression. We previously demonstrated that low-frequency electromagnetic stimulation (LF EMS), called bioresonance therapy (BRT), may both accelerate and inhibit the growth of transplantable hepatoma (Morris type 5123D), including total tumor regression. The aim of this study was to assess serum cathepsin activity during tumor progression and regression.
MATERIAL/METHODS: Of 60 female rats inoculated with Morris hepatoma cells, 45 were treated with BRT, and the remaining 15 were left without treatment. Fifteen rats without inoculated tumors served as controls. Serum cathepsin B activity was determined, tumor volumes were measured, and... (More)
BACKGROUND: Serum cathepsin B activity has been considered a potential marker of tumor progression. We previously demonstrated that low-frequency electromagnetic stimulation (LF EMS), called bioresonance therapy (BRT), may both accelerate and inhibit the growth of transplantable hepatoma (Morris type 5123D), including total tumor regression. The aim of this study was to assess serum cathepsin activity during tumor progression and regression.
MATERIAL/METHODS: Of 60 female rats inoculated with Morris hepatoma cells, 45 were treated with BRT, and the remaining 15 were left without treatment. Fifteen rats without inoculated tumors served as controls. Serum cathepsin B activity was determined, tumor volumes were measured, and histological examinations of the tumor tissues were performed.
RESULTS: Of the 45 BRT-treated rats, tumor regression was observed in 31 rats, and serum cathepsin activity was analyzed in these rats. In all non-treated rats, tumor progression was observed. Serum cathepsin B activity was significantly higher in both the BRT-treated group (27.8+/-4.1 U/l, p<0.01) and the tumor-bearing group (19.9+/-2.5 U/l, p<0.05), as compared to the controls (13.3+/-3.4 U/l).
CONCLUSIONS: Cathepsin B may play an important role, not only in tumor expansion, but also during the processes of cancer cell death and resorption. High circulating levels may thus correspond to effective therapeutic response in the course of antitumor treatment.
(Less)
- author
- Fedorowski, Artur
LU
; Steciwko, Andrzej
and Rabczyński, Jerzy
- publishing date
- 2004-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Apoptosis, Biomarkers, Tumor, Cathepsin B, Cell Death, Cell Division, Cell Line, Tumor, Disease Progression, Electromagnetic Phenomena, Female, Liver Neoplasms, Experimental, Necrosis, Neoplasm Transplantation, Rats, Treatment Outcome, Journal Article, Research Support, Non-U.S. Gov't
- in
- Medical Science Monitor
- volume
- 10
- issue
- 5
- article number
- 11644
- pages
- 7 pages
- publisher
- International Scientific Information (ISI)
- external identifiers
-
- pmid:15114263
- scopus:2942746586
- ISSN
- 1234-1010
- language
- English
- LU publication?
- no
- id
- cc540588-2a13-4db9-aa08-b251eadb7384
- alternative location
- https://www.medscimonit.com/download/index/idArt/11644
- date added to LUP
- 2018-04-04 12:38:31
- date last changed
- 2024-04-29 06:33:02
@article{cc540588-2a13-4db9-aa08-b251eadb7384,
abstract = {{<p>BACKGROUND: Serum cathepsin B activity has been considered a potential marker of tumor progression. We previously demonstrated that low-frequency electromagnetic stimulation (LF EMS), called bioresonance therapy (BRT), may both accelerate and inhibit the growth of transplantable hepatoma (Morris type 5123D), including total tumor regression. The aim of this study was to assess serum cathepsin activity during tumor progression and regression.</p><p>MATERIAL/METHODS: Of 60 female rats inoculated with Morris hepatoma cells, 45 were treated with BRT, and the remaining 15 were left without treatment. Fifteen rats without inoculated tumors served as controls. Serum cathepsin B activity was determined, tumor volumes were measured, and histological examinations of the tumor tissues were performed.</p><p>RESULTS: Of the 45 BRT-treated rats, tumor regression was observed in 31 rats, and serum cathepsin activity was analyzed in these rats. In all non-treated rats, tumor progression was observed. Serum cathepsin B activity was significantly higher in both the BRT-treated group (27.8+/-4.1 U/l, p<0.01) and the tumor-bearing group (19.9+/-2.5 U/l, p<0.05), as compared to the controls (13.3+/-3.4 U/l).</p><p>CONCLUSIONS: Cathepsin B may play an important role, not only in tumor expansion, but also during the processes of cancer cell death and resorption. High circulating levels may thus correspond to effective therapeutic response in the course of antitumor treatment.</p>}},
author = {{Fedorowski, Artur and Steciwko, Andrzej and Rabczyński, Jerzy}},
issn = {{1234-1010}},
keywords = {{Animals; Apoptosis; Biomarkers, Tumor; Cathepsin B; Cell Death; Cell Division; Cell Line, Tumor; Disease Progression; Electromagnetic Phenomena; Female; Liver Neoplasms, Experimental; Necrosis; Neoplasm Transplantation; Rats; Treatment Outcome; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
month = {{05}},
number = {{5}},
pages = {{50--144}},
publisher = {{International Scientific Information (ISI)}},
series = {{Medical Science Monitor}},
title = {{Serum cathepsin B activity during regression of Morris hepatoma 5123 D}},
url = {{https://www.medscimonit.com/download/index/idArt/11644}},
volume = {{10}},
year = {{2004}},
}