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Coeliac disease in children with type 1 diabetes

Kurppa, Kalle; Laitinen, Anna and Agardh, Daniel LU (2018) In The Lancet Child and Adolescent Health 2(2). p.133-143
Abstract

Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary... (More)

Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary treatment in children with coexisting type 1 diabetes, which can already be a burden. Furthermore, we present the latest research on the shared genetic and pathogenic mechanisms and introduce some future perspectives.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet Child and Adolescent Health
volume
2
issue
2
pages
11 pages
publisher
Elsevier
external identifiers
  • scopus:85041576654
ISSN
2352-4642
DOI
10.1016/S2352-4642(17)30172-4
language
English
LU publication?
yes
id
cc7225f4-24b0-4600-946a-31af1f2d6522
date added to LUP
2018-03-06 11:32:41
date last changed
2018-05-29 11:38:42
@article{cc7225f4-24b0-4600-946a-31af1f2d6522,
  abstract     = {<p>Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary treatment in children with coexisting type 1 diabetes, which can already be a burden. Furthermore, we present the latest research on the shared genetic and pathogenic mechanisms and introduce some future perspectives.</p>},
  author       = {Kurppa, Kalle and Laitinen, Anna and Agardh, Daniel},
  issn         = {2352-4642},
  language     = {eng},
  number       = {2},
  pages        = {133--143},
  publisher    = {Elsevier},
  series       = {The Lancet Child and Adolescent Health},
  title        = {Coeliac disease in children with type 1 diabetes},
  url          = {http://dx.doi.org/10.1016/S2352-4642(17)30172-4},
  volume       = {2},
  year         = {2018},
}