Coeliac disease in children with type 1 diabetes
(2018) In The Lancet Child and Adolescent Health 2(2). p.133-143- Abstract
Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary... (More)
Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary treatment in children with coexisting type 1 diabetes, which can already be a burden. Furthermore, we present the latest research on the shared genetic and pathogenic mechanisms and introduce some future perspectives.
(Less)
- author
- Kurppa, Kalle ; Laitinen, Anna and Agardh, Daniel LU
- organization
- publishing date
- 2018-02
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Lancet Child and Adolescent Health
- volume
- 2
- issue
- 2
- pages
- 11 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85041576654
- ISSN
- 2352-4642
- DOI
- 10.1016/S2352-4642(17)30172-4
- language
- English
- LU publication?
- yes
- id
- cc7225f4-24b0-4600-946a-31af1f2d6522
- date added to LUP
- 2018-03-06 11:32:41
- date last changed
- 2022-04-25 06:05:30
@article{cc7225f4-24b0-4600-946a-31af1f2d6522,
abstract = {{<p>Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary treatment in children with coexisting type 1 diabetes, which can already be a burden. Furthermore, we present the latest research on the shared genetic and pathogenic mechanisms and introduce some future perspectives.</p>}},
author = {{Kurppa, Kalle and Laitinen, Anna and Agardh, Daniel}},
issn = {{2352-4642}},
language = {{eng}},
number = {{2}},
pages = {{133--143}},
publisher = {{Elsevier}},
series = {{The Lancet Child and Adolescent Health}},
title = {{Coeliac disease in children with type 1 diabetes}},
url = {{http://dx.doi.org/10.1016/S2352-4642(17)30172-4}},
doi = {{10.1016/S2352-4642(17)30172-4}},
volume = {{2}},
year = {{2018}},
}