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Second primary malignancies in patients with male breast cancer

Hemminki, K LU ; Scélo, G; Boffetta, P; Mellemkjaer, L; Tracey, E; Andersen, A; Brewster, D H; Pukkala, E; McBride, M and Kliewer, E V, et al. (2005) In British Journal of Cancer 92(7). p.92-1288
Abstract

An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35-12.7), rectum (1.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, 1.65, 1.16-2.29), prostate (1.61, 1.34-1.93) and lymphohaematopoietic system (1.63, 1.12-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after... (More)

An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35-12.7), rectum (1.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, 1.65, 1.16-2.29), prostate (1.61, 1.34-1.93) and lymphohaematopoietic system (1.63, 1.12-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA1) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk.

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keywords
Adult, Aged, Breast Neoplasms, Male/complications, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Neoplasms, Second Primary/epidemiology, Registries/statistics & numerical data, Risk Factors
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British Journal of Cancer
volume
92
issue
7
pages
5 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:20944443183
ISSN
0007-0920
DOI
10.1038/sj.bjc.6602505
language
English
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no
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cc8beca3-ec21-44f1-8a44-96f4f3458c8d
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2019-01-30 11:40:26
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2019-03-12 04:20:23
@article{cc8beca3-ec21-44f1-8a44-96f4f3458c8d,
  abstract     = {<p>An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35-12.7), rectum (1.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, 1.65, 1.16-2.29), prostate (1.61, 1.34-1.93) and lymphohaematopoietic system (1.63, 1.12-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA1) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk.</p>},
  author       = {Hemminki, K and Scélo, G and Boffetta, P and Mellemkjaer, L and Tracey, E and Andersen, A and Brewster, D H and Pukkala, E and McBride, M and Kliewer, E V and Chia, K-S and Pompe-Kirn, V and Martos, C and Jonasson, J G and Li, Xinjun and Brennan, P},
  issn         = {0007-0920},
  keyword      = {Adult,Aged,Breast Neoplasms, Male/complications,Follow-Up Studies,Humans,Incidence,Male,Middle Aged,Neoplasms, Second Primary/epidemiology,Registries/statistics & numerical data,Risk Factors},
  language     = {eng},
  month        = {04},
  number       = {7},
  pages        = {92--1288},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Second primary malignancies in patients with male breast cancer},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6602505},
  volume       = {92},
  year         = {2005},
}