High water intake and low urine osmolality are associated with favorable metabolic profile at a population level : low vasopressin secretion as a possible explanation
(2020) In European Journal of Nutrition 59(8). p.3715-3722- Abstract
Purpose: Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low urine volume and high urine osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water intake or high u-Osm correlated with high fp-copeptin and components of the metabolic syndrome at the population level. Methods: In the population-based Malmö Offspring Study (MOS, n = 2599), fp-copeptin and u-Osm from morning urine samples were measured, and diet and total water intake (from beverages and food moisture) was assessed by a 4-day... (More)
Purpose: Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low urine volume and high urine osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water intake or high u-Osm correlated with high fp-copeptin and components of the metabolic syndrome at the population level. Methods: In the population-based Malmö Offspring Study (MOS, n = 2599), fp-copeptin and u-Osm from morning urine samples were measured, and diet and total water intake (from beverages and food moisture) was assessed by a 4-day web-based record. Results: Increasing water intake by tertile was after adjustment for age and sex associated with low fp-triglycerides (p = 0.002) and high fp-HDL (p = 0.004), whereas there was no association with the other investigated metabolic traits (HbA1c, fp-glucose, BMI or waist circumference). Increasing u-Osm by tertile was, after adjustment for age and sex, associated with high fp-glucose (p = 0.007), and borderline significantly associated with high HbA1c (p = 0.053), but no association was observed with fp-HDL, fp-triglycerides, BMI or waist circumference. Fp-copeptin concentration correlated significantly with water intake (r = − 0.13, p < 0.001) and u-Osm (r = 0.27, p < 0.001). High copeptin was associated with all investigated metabolic traits (p < 0.001 for all). Conclusion: Low concentrations of the vasopressin marker copeptin is linked to high water intake, low u-Osm, and a favorable metabolic profile, suggesting that vasopressin lowering lifestyle interventions, such as increased water intake, may promote metabolic health.
(Less)
- author
- Brunkwall, Louise LU ; Ericson, Ulrika LU ; Nilsson, Peter M. LU and Enhörning, Sofia LU
- organization
- publishing date
- 2020-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Copeptin, Glucose, High-density lipoprotein, Urine osmolality, Vasopressin, Water intake
- in
- European Journal of Nutrition
- volume
- 59
- issue
- 8
- pages
- 8 pages
- publisher
- Springer
- external identifiers
-
- scopus:85079701876
- pmid:32072267
- ISSN
- 1436-6207
- DOI
- 10.1007/s00394-020-02202-7
- language
- English
- LU publication?
- yes
- id
- ccef745a-ba02-4179-b8e1-6c95d5d1cae1
- date added to LUP
- 2020-03-05 12:21:15
- date last changed
- 2024-04-17 04:46:07
@article{ccef745a-ba02-4179-b8e1-6c95d5d1cae1,
abstract = {{<p>Purpose: Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low urine volume and high urine osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water intake or high u-Osm correlated with high fp-copeptin and components of the metabolic syndrome at the population level. Methods: In the population-based Malmö Offspring Study (MOS, n = 2599), fp-copeptin and u-Osm from morning urine samples were measured, and diet and total water intake (from beverages and food moisture) was assessed by a 4-day web-based record. Results: Increasing water intake by tertile was after adjustment for age and sex associated with low fp-triglycerides (p = 0.002) and high fp-HDL (p = 0.004), whereas there was no association with the other investigated metabolic traits (HbA1c, fp-glucose, BMI or waist circumference). Increasing u-Osm by tertile was, after adjustment for age and sex, associated with high fp-glucose (p = 0.007), and borderline significantly associated with high HbA1c (p = 0.053), but no association was observed with fp-HDL, fp-triglycerides, BMI or waist circumference. Fp-copeptin concentration correlated significantly with water intake (r = − 0.13, p < 0.001) and u-Osm (r = 0.27, p < 0.001). High copeptin was associated with all investigated metabolic traits (p < 0.001 for all). Conclusion: Low concentrations of the vasopressin marker copeptin is linked to high water intake, low u-Osm, and a favorable metabolic profile, suggesting that vasopressin lowering lifestyle interventions, such as increased water intake, may promote metabolic health.</p>}},
author = {{Brunkwall, Louise and Ericson, Ulrika and Nilsson, Peter M. and Enhörning, Sofia}},
issn = {{1436-6207}},
keywords = {{Copeptin; Glucose; High-density lipoprotein; Urine osmolality; Vasopressin; Water intake}},
language = {{eng}},
number = {{8}},
pages = {{3715--3722}},
publisher = {{Springer}},
series = {{European Journal of Nutrition}},
title = {{High water intake and low urine osmolality are associated with favorable metabolic profile at a population level : low vasopressin secretion as a possible explanation}},
url = {{http://dx.doi.org/10.1007/s00394-020-02202-7}},
doi = {{10.1007/s00394-020-02202-7}},
volume = {{59}},
year = {{2020}},
}