Identification of brain tumours in rats using laser-induced fluorescence and haematoporphyrin derivative
(1989) In Lasers in Medical Science 4(4). p.241-249- Abstract
- Laser-induced fluorescence has been used for the identification of brain tumours in rats, which have been previously given tumour-seeking haematoporphyrin derivative. A pulsed nitrogen laser (λ=337 nm) was used in conjunction with an optical multichannel analyzer. For both inoculated RG-2 and TCVC rat-brain-tumour models, the blue autofluorescence was strongly reduced in the tumour compared with normal brain tissue, and at the same time the characteristic red-drug signal increased. The contrast between tumour and normal tissue was strongly enhanced by forming the ratio between the two signals. Implications for possible improvement of tumour delineation in brain tumour surgery are discussed.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2257267
- author
- Andersson-Engels, Stefan LU ; Brun, A ; Kjellén, E ; Salford, L.G ; Strömblad, L.-G ; Svanberg, Katarina LU and Svanberg, Sune LU
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Medicine
- in
- Lasers in Medical Science
- volume
- 4
- issue
- 4
- pages
- 9 pages
- publisher
- Springer
- external identifiers
-
- scopus:0024955528
- ISSN
- 0268-8921
- DOI
- 10.1007/BF02032454
- language
- English
- LU publication?
- yes
- id
- cd1e6b5c-79a6-43a9-bf68-6f5b04a3c10a (old id 2257267)
- date added to LUP
- 2016-04-01 17:08:54
- date last changed
- 2023-02-24 11:33:11
@article{cd1e6b5c-79a6-43a9-bf68-6f5b04a3c10a, abstract = {{Laser-induced fluorescence has been used for the identification of brain tumours in rats, which have been previously given tumour-seeking haematoporphyrin derivative. A pulsed nitrogen laser (λ=337 nm) was used in conjunction with an optical multichannel analyzer. For both inoculated RG-2 and TCVC rat-brain-tumour models, the blue autofluorescence was strongly reduced in the tumour compared with normal brain tissue, and at the same time the characteristic red-drug signal increased. The contrast between tumour and normal tissue was strongly enhanced by forming the ratio between the two signals. Implications for possible improvement of tumour delineation in brain tumour surgery are discussed.}}, author = {{Andersson-Engels, Stefan and Brun, A and Kjellén, E and Salford, L.G and Strömblad, L.-G and Svanberg, Katarina and Svanberg, Sune}}, issn = {{0268-8921}}, keywords = {{Medicine}}, language = {{eng}}, number = {{4}}, pages = {{241--249}}, publisher = {{Springer}}, series = {{Lasers in Medical Science}}, title = {{Identification of brain tumours in rats using laser-induced fluorescence and haematoporphyrin derivative}}, url = {{https://lup.lub.lu.se/search/files/4889256/2365643.pdf}}, doi = {{10.1007/BF02032454}}, volume = {{4}}, year = {{1989}}, }