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Phase-locked magnetomotive ultrasound imaging of superparamagnetic iron-oxide nanoparticles

Holst, Maria ; Cinthio, Magnus LU orcid ; Fredriksson, Sarah ; Olsson, Fredrik ; Persson, Hans W. LU and Jansson, Tomas LU (2010) 2010 IEEE International Ultrasonics Symposium, IUS 2010 p.1007-1010
Abstract

It has recently been shown that superparamagnetic iron oxide nanoparticles (SPIO-NP) can be used as ultrasound contrast agents, by moving the particles using a time-varying external magnetic field and thereby moving nanoparticle laden tissue. However, the difficulty to distinguish magneto-motive motion from indirect motion induced outside areas containing nanoparticles, or other motion artifacts, which restrict the use in vivo, is not well reported. Using a high-frequency linear array system we found that displacements outside nanoparticle-laden areas could be in the same range as the displacement in areas containing nanoparticles. We also found in our setup that the movement in areas between the nanoparticles areas were approximately... (More)

It has recently been shown that superparamagnetic iron oxide nanoparticles (SPIO-NP) can be used as ultrasound contrast agents, by moving the particles using a time-varying external magnetic field and thereby moving nanoparticle laden tissue. However, the difficulty to distinguish magneto-motive motion from indirect motion induced outside areas containing nanoparticles, or other motion artifacts, which restrict the use in vivo, is not well reported. Using a high-frequency linear array system we found that displacements outside nanoparticle-laden areas could be in the same range as the displacement in areas containing nanoparticles. We also found in our setup that the movement in areas between the nanoparticles areas were approximately radians out of phase relative the nanoparticles areas. To suppress undesirable signals we developed an algorithm based on frequency-tracking and phase-locking, where the energy of the processed signal is color-coded and overlaid on the B-mode image. The signal-to-clutter ratio showed a 14.5 dB improvement between the image color-coded with the total power and the image coded with regard to phase and frequency. The capability to distinguish areas containing SPIO-NP from those that do not is a crucial step for detection of nanoparticles in vivo.

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Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
contrast agents, molecular imaging, multimodal imaging, phase detection
host publication
2010 IEEE International Ultrasonics Symposium, IUS 2010
article number
5935431
pages
4 pages
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
conference name
2010 IEEE International Ultrasonics Symposium, IUS 2010
conference location
San Diego, CA, United States
conference dates
2010-10-11 - 2010-10-14
external identifiers
  • scopus:80054774750
ISBN
978-1-4577-0381-2
9781457703829
DOI
10.1109/ULTSYM.2010.5935431
language
English
LU publication?
yes
id
cd6a7258-788b-462c-b453-901adc7155f8
date added to LUP
2019-05-29 13:45:39
date last changed
2025-01-08 12:08:13
@inproceedings{cd6a7258-788b-462c-b453-901adc7155f8,
  abstract     = {{<p>It has recently been shown that superparamagnetic iron oxide nanoparticles (SPIO-NP) can be used as ultrasound contrast agents, by moving the particles using a time-varying external magnetic field and thereby moving nanoparticle laden tissue. However, the difficulty to distinguish magneto-motive motion from indirect motion induced outside areas containing nanoparticles, or other motion artifacts, which restrict the use in vivo, is not well reported. Using a high-frequency linear array system we found that displacements outside nanoparticle-laden areas could be in the same range as the displacement in areas containing nanoparticles. We also found in our setup that the movement in areas between the nanoparticles areas were approximately radians out of phase relative the nanoparticles areas. To suppress undesirable signals we developed an algorithm based on frequency-tracking and phase-locking, where the energy of the processed signal is color-coded and overlaid on the B-mode image. The signal-to-clutter ratio showed a 14.5 dB improvement between the image color-coded with the total power and the image coded with regard to phase and frequency. The capability to distinguish areas containing SPIO-NP from those that do not is a crucial step for detection of nanoparticles in vivo.</p>}},
  author       = {{Holst, Maria and Cinthio, Magnus and Fredriksson, Sarah and Olsson, Fredrik and Persson, Hans W. and Jansson, Tomas}},
  booktitle    = {{2010 IEEE International Ultrasonics Symposium, IUS 2010}},
  isbn         = {{978-1-4577-0381-2}},
  keywords     = {{contrast agents; molecular imaging; multimodal imaging; phase detection}},
  language     = {{eng}},
  month        = {{12}},
  pages        = {{1007--1010}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  title        = {{Phase-locked magnetomotive ultrasound imaging of superparamagnetic iron-oxide nanoparticles}},
  url          = {{http://dx.doi.org/10.1109/ULTSYM.2010.5935431}},
  doi          = {{10.1109/ULTSYM.2010.5935431}},
  year         = {{2010}},
}