Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

New connections of medication use and polypharmacy with the gut microbiota composition and functional potential in a large population

Larsson, Anna LU ; Ericson, Ulrika LU ; Jönsson, Daniel LU ; Miari, Mariam LU ; Athanasiadis, Paschalis LU ; Baldanzi, Gabriel ; Brunkwall, Louise LU ; Hellstrand, Sophie LU ; Klinge, Björn and Melander, Olle LU orcid , et al. (2024) In Scientific Reports 14(1).
Abstract

Medication can affect the gut microbiota composition and function. The aim of this study was to investigate connections between use of common non-antibiotic medicines and the gut microbiota composition and function in a large Swedish cohort (N = 2223). Use of 67 medications and polypharmacy (≥ 5 medications), based on self-reported and prescription registry data, were associated with the relative abundance of 881 gut metagenomic species (> 5% prevalence) and 103 gut metabolic modules (GMMs). Altogether, 97 associations of 26 medications with 40 species and of four medications with five GMMs were observed (false discovery rate < 5%). Several earlier findings were replicated like the positive associations of proton pump inhibitors... (More)

Medication can affect the gut microbiota composition and function. The aim of this study was to investigate connections between use of common non-antibiotic medicines and the gut microbiota composition and function in a large Swedish cohort (N = 2223). Use of 67 medications and polypharmacy (≥ 5 medications), based on self-reported and prescription registry data, were associated with the relative abundance of 881 gut metagenomic species (> 5% prevalence) and 103 gut metabolic modules (GMMs). Altogether, 97 associations of 26 medications with 40 species and of four medications with five GMMs were observed (false discovery rate < 5%). Several earlier findings were replicated like the positive associations of proton pump inhibitors (PPIs) with numerous oral species, and those of metformin with Escherichia species and with lactate consumption I and arginine degradation II. Several new associations were observed between, among others, use of antidepressants, beta-blockers, nonsteroidal anti-inflammatory drugs and calcium channel blockers, and specific species. Polypharmacy was positively associated with Enterococcus faecalis, Bacteroides uniformis, Rothia mucilaginosa, Escherichia coli and Limosilactobacillus vaginalis, and with 13 GMMs. We confirmed several previous findings and identified numerous new associations between use of medications/polypharmacy and the gut microbiota composition and functional potential. Further studies are needed to confirm the new findings.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gut metabolic modules, Gut microbiota, Medications, Polypharmacy, Population cohort, Shotgun metagenomics
in
Scientific Reports
volume
14
issue
1
article number
23723
publisher
Nature Publishing Group
external identifiers
  • pmid:39390025
  • scopus:85206055085
ISSN
2045-2322
DOI
10.1038/s41598-024-71571-4
language
English
LU publication?
yes
id
cd9f76fb-7b39-4f3a-9555-cc2d66e1c5ab
date added to LUP
2024-11-27 15:36:09
date last changed
2025-07-10 10:18:34
@article{cd9f76fb-7b39-4f3a-9555-cc2d66e1c5ab,
  abstract     = {{<p>Medication can affect the gut microbiota composition and function. The aim of this study was to investigate connections between use of common non-antibiotic medicines and the gut microbiota composition and function in a large Swedish cohort (N = 2223). Use of 67 medications and polypharmacy (≥ 5 medications), based on self-reported and prescription registry data, were associated with the relative abundance of 881 gut metagenomic species (&gt; 5% prevalence) and 103 gut metabolic modules (GMMs). Altogether, 97 associations of 26 medications with 40 species and of four medications with five GMMs were observed (false discovery rate &lt; 5%). Several earlier findings were replicated like the positive associations of proton pump inhibitors (PPIs) with numerous oral species, and those of metformin with Escherichia species and with lactate consumption I and arginine degradation II. Several new associations were observed between, among others, use of antidepressants, beta-blockers, nonsteroidal anti-inflammatory drugs and calcium channel blockers, and specific species. Polypharmacy was positively associated with Enterococcus faecalis, Bacteroides uniformis, Rothia mucilaginosa, Escherichia coli and Limosilactobacillus vaginalis, and with 13 GMMs. We confirmed several previous findings and identified numerous new associations between use of medications/polypharmacy and the gut microbiota composition and functional potential. Further studies are needed to confirm the new findings.</p>}},
  author       = {{Larsson, Anna and Ericson, Ulrika and Jönsson, Daniel and Miari, Mariam and Athanasiadis, Paschalis and Baldanzi, Gabriel and Brunkwall, Louise and Hellstrand, Sophie and Klinge, Björn and Melander, Olle and Nilsson, Peter M. and Fall, Tove and Maziarz, Marlena and Orho-Melander, Marju}},
  issn         = {{2045-2322}},
  keywords     = {{Gut metabolic modules; Gut microbiota; Medications; Polypharmacy; Population cohort; Shotgun metagenomics}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{New connections of medication use and polypharmacy with the gut microbiota composition and functional potential in a large population}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-71571-4}},
  doi          = {{10.1038/s41598-024-71571-4}},
  volume       = {{14}},
  year         = {{2024}},
}