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Osteoprotegerin autoantibodies do not predict low bone mineral density in middle-aged women

Vaziri-Sani, Fariba LU ; Brundin, Charlotte LU and Agardh, Daniel LU (2017) In Bone Reports 7. p.132-136
Abstract

Purpose Autoantibodies against osteoprotegerin (OPG) have been associated with osteoporosis. The aim was to develop an immunoassay for OPG autoantibodies and test their diagnostic usefulness of identifying women general population with low bone mineral density. Methods Included were 698 women at mean age 55.1 years (range 50.4–60.6) randomly selected from the general population. Measurement of wrist bone mineral density (g/cm2) was performed of the non-dominant wrist by dual-energy X-ray absorptiometry (DXA). A T-score < − 2.5 was defined as having a low bone mineral density. Measurements of OPG autoantibodies were carried by radiobinding assays. Cut-off levels for a positive value were determined from the deviation from... (More)

Purpose Autoantibodies against osteoprotegerin (OPG) have been associated with osteoporosis. The aim was to develop an immunoassay for OPG autoantibodies and test their diagnostic usefulness of identifying women general population with low bone mineral density. Methods Included were 698 women at mean age 55.1 years (range 50.4–60.6) randomly selected from the general population. Measurement of wrist bone mineral density (g/cm2) was performed of the non-dominant wrist by dual-energy X-ray absorptiometry (DXA). A T-score < − 2.5 was defined as having a low bone mineral density. Measurements of OPG autoantibodies were carried by radiobinding assays. Cut-off levels for a positive value were determined from the deviation from normality in the distribution of 398 healthy blood donors representing the 99.7th percentile. Results Forty-five of the 698 (6.6%) women were IgG-OPG positive compared with 2 of 398 (0.5%) controls (p < 0.0001) and 35 of the 698 (5.0%) women had a T-score < − 2.5. There was no difference in bone mineral density between IgG-OPG positive (median 0.439 (range 0.315–0.547) g/cm2) women and IgG-OPG negative (median 0.435 (range 0.176–0.652) g/cm2) women (p = 0.3956). Furthermore, there was neither a correlation between IgG-OPG levels and bone mineral density (rs = 0.1896; p = 0.2068) nor T-score (rs = 0.1889; p = 0.2086). Diagnostic sensitivity and specificity of IgG-OPG for low bone mineral density were 5.7% and 92.9%, and positive and negative predictive values were 7.4% and 90.8%, respectively. Conclusion Elevated OPG autoantibody levels do not predict low bone mineral density in middle-aged women selected from the general population.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoantibody, Bone mineral density, Osteopenia, Osteoporosis, Osteoprotegerin
in
Bone Reports
volume
7
pages
5 pages
publisher
Elsevier Inc.
external identifiers
  • scopus:85032296063
  • pmid: 29124083
DOI
10.1016/j.bonr.2017.10.004
language
English
LU publication?
yes
id
ce9fc6aa-d524-4160-9a01-0175083bf531
date added to LUP
2017-11-12 15:20:25
date last changed
2018-07-08 04:28:16
@article{ce9fc6aa-d524-4160-9a01-0175083bf531,
  abstract     = {<p>Purpose Autoantibodies against osteoprotegerin (OPG) have been associated with osteoporosis. The aim was to develop an immunoassay for OPG autoantibodies and test their diagnostic usefulness of identifying women general population with low bone mineral density. Methods Included were 698 women at mean age 55.1 years (range 50.4–60.6) randomly selected from the general population. Measurement of wrist bone mineral density (g/cm<sup>2</sup>) was performed of the non-dominant wrist by dual-energy X-ray absorptiometry (DXA). A T-score &lt; − 2.5 was defined as having a low bone mineral density. Measurements of OPG autoantibodies were carried by radiobinding assays. Cut-off levels for a positive value were determined from the deviation from normality in the distribution of 398 healthy blood donors representing the 99.7th percentile. Results Forty-five of the 698 (6.6%) women were IgG-OPG positive compared with 2 of 398 (0.5%) controls (p &lt; 0.0001) and 35 of the 698 (5.0%) women had a T-score &lt; − 2.5. There was no difference in bone mineral density between IgG-OPG positive (median 0.439 (range 0.315–0.547) g/cm<sup>2</sup>) women and IgG-OPG negative (median 0.435 (range 0.176–0.652) g/cm<sup>2</sup>) women (p = 0.3956). Furthermore, there was neither a correlation between IgG-OPG levels and bone mineral density (r<sub>s</sub> = 0.1896; p = 0.2068) nor T-score (r<sub>s</sub> = 0.1889; p = 0.2086). Diagnostic sensitivity and specificity of IgG-OPG for low bone mineral density were 5.7% and 92.9%, and positive and negative predictive values were 7.4% and 90.8%, respectively. Conclusion Elevated OPG autoantibody levels do not predict low bone mineral density in middle-aged women selected from the general population.</p>},
  author       = {Vaziri-Sani, Fariba and Brundin, Charlotte and Agardh, Daniel},
  keyword      = {Autoantibody,Bone mineral density,Osteopenia,Osteoporosis,Osteoprotegerin},
  language     = {eng},
  month        = {12},
  pages        = {132--136},
  publisher    = {Elsevier Inc.},
  series       = {Bone Reports},
  title        = {Osteoprotegerin autoantibodies do not predict low bone mineral density in middle-aged women},
  url          = {http://dx.doi.org/10.1016/j.bonr.2017.10.004},
  volume       = {7},
  year         = {2017},
}