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Safety of pancreatic resection in the elderly : a retrospective analysis of 556 patients

Ansari, Daniel LU ; Aronsson, Linus LU ; Fredriksson, Joakim ; Andersson, Bodil LU orcid and Andersson, Roland LU (2016) In Annals of Gastroenterology 29(2). p.5-221
Abstract

BACKGROUND: The safety of pancreatic resection for elderly patients is still controversial. We examined the postoperative morbidity and mortality in patients aged 75 years or more undergoing pancreatic resection.

METHODS: Patients undergoing pancreatic resection were studied retrospectively and the outcomes were compared between patients aged <75 and ≥75 years.

RESULTS: Of the 556 patients enrolled, 78 (14%) were ≥75 years old. Elderly patients had significantly more co-morbidities, especially cardiovascular pathology (P=0.005). Also, elderly patients had significantly lower body mass index prior to surgery (P=0.005). There were no significant differences in terms of surgical procedures and tumor types between age groups.... (More)

BACKGROUND: The safety of pancreatic resection for elderly patients is still controversial. We examined the postoperative morbidity and mortality in patients aged 75 years or more undergoing pancreatic resection.

METHODS: Patients undergoing pancreatic resection were studied retrospectively and the outcomes were compared between patients aged <75 and ≥75 years.

RESULTS: Of the 556 patients enrolled, 78 (14%) were ≥75 years old. Elderly patients had significantly more co-morbidities, especially cardiovascular pathology (P=0.005). Also, elderly patients had significantly lower body mass index prior to surgery (P=0.005). There were no significant differences in terms of surgical procedures and tumor types between age groups. The incidence of postoperative pancreatic fistula grade A was significantly lower in the elderly group (P=0.022), but no significant differences were noted in the overall morbidity or the incidence of postpancreatectomy hemorrhage, delayed gastric emptying, bile leakage, cardiac complications, pulmonary complications or septic complications. The 30-day mortality rate was similar between groups (0.8% vs. 1.3%; P=0.532).

CONCLUSION: Pancreatic resection is a safe option for selected elderly patients. Our study confirms that age alone should not preclude potentially curative surgical therapy.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Gastroenterology
volume
29
issue
2
pages
5 pages
publisher
Hellenic Society of Gastroenterology
external identifiers
  • pmid:27065736
  • scopus:84962366074
  • wos:000378933700017
ISSN
1108-7471
DOI
10.20524/aog.2016.0016
project
Pancreatic cancer
language
English
LU publication?
yes
id
cea5c9ef-a995-47be-8928-c530bc06aba6
date added to LUP
2016-05-04 08:44:41
date last changed
2024-03-06 21:58:11
@article{cea5c9ef-a995-47be-8928-c530bc06aba6,
  abstract     = {{<p>BACKGROUND: The safety of pancreatic resection for elderly patients is still controversial. We examined the postoperative morbidity and mortality in patients aged 75 years or more undergoing pancreatic resection.</p><p>METHODS: Patients undergoing pancreatic resection were studied retrospectively and the outcomes were compared between patients aged &lt;75 and ≥75 years.</p><p>RESULTS: Of the 556 patients enrolled, 78 (14%) were ≥75 years old. Elderly patients had significantly more co-morbidities, especially cardiovascular pathology (P=0.005). Also, elderly patients had significantly lower body mass index prior to surgery (P=0.005). There were no significant differences in terms of surgical procedures and tumor types between age groups. The incidence of postoperative pancreatic fistula grade A was significantly lower in the elderly group (P=0.022), but no significant differences were noted in the overall morbidity or the incidence of postpancreatectomy hemorrhage, delayed gastric emptying, bile leakage, cardiac complications, pulmonary complications or septic complications. The 30-day mortality rate was similar between groups (0.8% vs. 1.3%; P=0.532).</p><p>CONCLUSION: Pancreatic resection is a safe option for selected elderly patients. Our study confirms that age alone should not preclude potentially curative surgical therapy.</p>}},
  author       = {{Ansari, Daniel and Aronsson, Linus and Fredriksson, Joakim and Andersson, Bodil and Andersson, Roland}},
  issn         = {{1108-7471}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{5--221}},
  publisher    = {{Hellenic Society of Gastroenterology}},
  series       = {{Annals of Gastroenterology}},
  title        = {{Safety of pancreatic resection in the elderly : a retrospective analysis of 556 patients}},
  url          = {{http://dx.doi.org/10.20524/aog.2016.0016}},
  doi          = {{10.20524/aog.2016.0016}},
  volume       = {{29}},
  year         = {{2016}},
}