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Relationship between natriuretic peptides and echocardiography parameters in patients with poorly regulated type 2 diabetes.

Dencker, Magnus LU ; Stagmo, Martin LU and Dorkhan, Mozhgan LU (2010) In Vascular Health and Risk Management 6. p.373-382
Abstract
This study evaluated the relationship between natriuretic peptide levels and a wide range of echocardiography parameters in a population of thirty-three patients with poorly regulated type 2 diabetes, and no known heart failure. Natriuretic peptides brain natriuretic peptide (BNP) and N-terminal prohormone BNP (NT-proBNP) were measured. Transthoracic echocardiography was performed and cardiac volumes and ejection fraction were measured. Doppler and tissue Doppler were measured and diastolic function was stratified according to recent guidelines. Very few echocardiography parameters were correlated with BNP or NT-proBNP levels. However, left atrial end-systolic volume indexed for body surface area was correlated with natural logarithm (ln)... (More)
This study evaluated the relationship between natriuretic peptide levels and a wide range of echocardiography parameters in a population of thirty-three patients with poorly regulated type 2 diabetes, and no known heart failure. Natriuretic peptides brain natriuretic peptide (BNP) and N-terminal prohormone BNP (NT-proBNP) were measured. Transthoracic echocardiography was performed and cardiac volumes and ejection fraction were measured. Doppler and tissue Doppler were measured and diastolic function was stratified according to recent guidelines. Very few echocardiography parameters were correlated with BNP or NT-proBNP levels. However, left atrial end-systolic volume indexed for body surface area was correlated with natural logarithm (ln) BNP and ln NT-proBNP (r=0.62 and r=0.60; P<0.05). There were significant differences in ln BNP and ln NT-proBNP levels between those with normal and those with abnormal diastolic function (1.4 vs 3.1; P<0.001 and 3.4 vs 5.8; P<0.001). This study showed that very few echocardiography parameters were correlated with BNP or NT-proBNP levels in patients with poorly regulated type 2 diabetes, which in part contradicts previous studies in other diabetic populations. The exception was left atrial end-systolic volume that showed a moderate correlation with BNP or NT-proBNP levels. There were significant differences in BNP and NT-proBNP levels between the group with normal left ventricular diastolic function and the group with abnormal diastolic function. (Less)
Please use this url to cite or link to this publication:
author
; and
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publishing date
type
Contribution to journal
publication status
published
subject
in
Vascular Health and Risk Management
volume
6
pages
373 - 382
publisher
Dove Medical Press Ltd.
external identifiers
  • pmid:20539839
  • scopus:77955855054
ISSN
1178-2048
language
English
LU publication?
yes
id
ced0a839-ff45-4f4d-880d-6a9582d67857 (old id 1626182)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20539839?dopt=Abstract
date added to LUP
2016-04-04 08:55:48
date last changed
2024-01-12 07:43:38
@article{ced0a839-ff45-4f4d-880d-6a9582d67857,
  abstract     = {{This study evaluated the relationship between natriuretic peptide levels and a wide range of echocardiography parameters in a population of thirty-three patients with poorly regulated type 2 diabetes, and no known heart failure. Natriuretic peptides brain natriuretic peptide (BNP) and N-terminal prohormone BNP (NT-proBNP) were measured. Transthoracic echocardiography was performed and cardiac volumes and ejection fraction were measured. Doppler and tissue Doppler were measured and diastolic function was stratified according to recent guidelines. Very few echocardiography parameters were correlated with BNP or NT-proBNP levels. However, left atrial end-systolic volume indexed for body surface area was correlated with natural logarithm (ln) BNP and ln NT-proBNP (r=0.62 and r=0.60; P&lt;0.05). There were significant differences in ln BNP and ln NT-proBNP levels between those with normal and those with abnormal diastolic function (1.4 vs 3.1; P&lt;0.001 and 3.4 vs 5.8; P&lt;0.001). This study showed that very few echocardiography parameters were correlated with BNP or NT-proBNP levels in patients with poorly regulated type 2 diabetes, which in part contradicts previous studies in other diabetic populations. The exception was left atrial end-systolic volume that showed a moderate correlation with BNP or NT-proBNP levels. There were significant differences in BNP and NT-proBNP levels between the group with normal left ventricular diastolic function and the group with abnormal diastolic function.}},
  author       = {{Dencker, Magnus and Stagmo, Martin and Dorkhan, Mozhgan}},
  issn         = {{1178-2048}},
  language     = {{eng}},
  pages        = {{373--382}},
  publisher    = {{Dove Medical Press Ltd.}},
  series       = {{Vascular Health and Risk Management}},
  title        = {{Relationship between natriuretic peptides and echocardiography parameters in patients with poorly regulated type 2 diabetes.}},
  url          = {{https://lup.lub.lu.se/search/files/5212758/1628188.pdf}},
  volume       = {{6}},
  year         = {{2010}},
}