Circulating anti-pericyte autoantibodies are present in Type 2 diabetic patients and are associated with non-proliferative retinopathy
(2003) In Diabetologia 46(4). p.511-513- Abstract
- Aims/Hypothesis. This study aims to determine the prevalence of anti-pericyte autoantibodies in Type 2 diabetes and to characterize these autoantibodies as new markers of disease activity in diabetic retinopathy. Methods. A total of 299 patients with Type 2 diabetes participated in this study. Retinopathy was assessed by 7-field stereo fundus photography and was graded according to the ETDRS scale. Serum anti-pericyte autoantibodies were detected by immunofluorescence on tissue cultured bovine retinal pericytes. Results. The prevalence of anti-pericyte autoantibodies in Type 2 diabetic patients was 54% and was approximately equal in men and women. The prevalence was approximately 55% with retinopathy at grades from 10 to 53. At grades... (More)
- Aims/Hypothesis. This study aims to determine the prevalence of anti-pericyte autoantibodies in Type 2 diabetes and to characterize these autoantibodies as new markers of disease activity in diabetic retinopathy. Methods. A total of 299 patients with Type 2 diabetes participated in this study. Retinopathy was assessed by 7-field stereo fundus photography and was graded according to the ETDRS scale. Serum anti-pericyte autoantibodies were detected by immunofluorescence on tissue cultured bovine retinal pericytes. Results. The prevalence of anti-pericyte autoantibodies in Type 2 diabetic patients was 54% and was approximately equal in men and women. The prevalence was approximately 55% with retinopathy at grades from 10 to 53. At grades above 53 the prevalence declined to 23% (p<0.0001). The highest prevalence by duration of diabetes, 70%, was found at 0 to 5 years and the lowest, 25% at more than 25 years duration (p<0.0001). Conclusion/interpretation. Anti-pericyte autoantibodies are present at high prevalence in Type 2 diabetes. Their presence during earlier stages of retinopathy could be due to a reaction with antigens expressed by "activated" pericytes. The decline in antibody prevalence in advanced retinopathy could mark pericyte loss and progression to an angiogenic retinal milieu. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/900368
- author
- Nayak, RC ; Agardh, Carl-David LU ; Kwok, MGK ; Stjernquist, Håkan LU ; Farthing-Nayak, PJ and Agardh, Elisabet LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- capillaries, retinal diseases, autommunity, diabetic retinopathy, pericytes, diabetes mellitus
- in
- Diabetologia
- volume
- 46
- issue
- 4
- pages
- 511 - 513
- publisher
- Springer
- external identifiers
-
- wos:000183198600010
- pmid:12739023
- scopus:0038632185
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-003-1057-0
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300), Ophthalmology (013242810), Unit on Vascular Diabetic Complications (013241510)
- id
- cef64cef-d1a0-4fef-b23e-d5962c820cc9 (old id 900368)
- date added to LUP
- 2016-04-01 12:23:50
- date last changed
- 2022-02-11 06:26:04
@article{cef64cef-d1a0-4fef-b23e-d5962c820cc9, abstract = {{Aims/Hypothesis. This study aims to determine the prevalence of anti-pericyte autoantibodies in Type 2 diabetes and to characterize these autoantibodies as new markers of disease activity in diabetic retinopathy. Methods. A total of 299 patients with Type 2 diabetes participated in this study. Retinopathy was assessed by 7-field stereo fundus photography and was graded according to the ETDRS scale. Serum anti-pericyte autoantibodies were detected by immunofluorescence on tissue cultured bovine retinal pericytes. Results. The prevalence of anti-pericyte autoantibodies in Type 2 diabetic patients was 54% and was approximately equal in men and women. The prevalence was approximately 55% with retinopathy at grades from 10 to 53. At grades above 53 the prevalence declined to 23% (p<0.0001). The highest prevalence by duration of diabetes, 70%, was found at 0 to 5 years and the lowest, 25% at more than 25 years duration (p<0.0001). Conclusion/interpretation. Anti-pericyte autoantibodies are present at high prevalence in Type 2 diabetes. Their presence during earlier stages of retinopathy could be due to a reaction with antigens expressed by "activated" pericytes. The decline in antibody prevalence in advanced retinopathy could mark pericyte loss and progression to an angiogenic retinal milieu.}}, author = {{Nayak, RC and Agardh, Carl-David and Kwok, MGK and Stjernquist, Håkan and Farthing-Nayak, PJ and Agardh, Elisabet}}, issn = {{1432-0428}}, keywords = {{capillaries; retinal diseases; autommunity; diabetic retinopathy; pericytes; diabetes mellitus}}, language = {{eng}}, number = {{4}}, pages = {{511--513}}, publisher = {{Springer}}, series = {{Diabetologia}}, title = {{Circulating anti-pericyte autoantibodies are present in Type 2 diabetic patients and are associated with non-proliferative retinopathy}}, url = {{http://dx.doi.org/10.1007/s00125-003-1057-0}}, doi = {{10.1007/s00125-003-1057-0}}, volume = {{46}}, year = {{2003}}, }